Effectiveness of Various Dosages and Administration Methods of Tanezumab for the Treatment of Pain in Knee and Hip Osteoarthritis: a Network Meta-Analysis

Cai, Youzhi; Ruan, Jiaqi; Zhao, Kun

doi:10.1016/j.clinthera.2021.10.011

Cited by 1 publication

(1 citation statement)

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“…Both groups in this study performed continuous flushing of the joint cavity simultaneously through arthroscopic surgery to remove inflammatory media and inflammatory proteins, reduce pressure in the knee cavity, and regulate and improve the knee cavity acidity and the role of osmotic pressure, clinically found that the knee's inflammatory slip membrane through the arthroscopic removal can directly reduce the knee-slip membrane inflammation on the knee erosion effect, but it also can remove inflammatory factors and reduce cytokines into the blood circulation, thus reducing the damage caused to other joints; this study of sliding membrane removal can effectively reduce the above-mentioned “inflammatory pain,” but it is also an effective prevention of knee erosion [ 12 ].…”

Section: Methods In Treating Akpmentioning

confidence: 99%

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Sun

Huang²

2022

Applied Bionics and Biomechanics

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Objective. To evaluate the efficacy and adverse reactions of arthroscopic half-moon plate invasive surgery (DEB) in patients with knee pain (AKP) using meta-analysis techniques. Methods. The computer retrieves from the English databases PubMed, EMBASE, Cochrane Library, and Web of Science and the Chinese databases China Knowledge Network, Wanfang Database, VIP Database, and China Biomedical Literature Database to collect information about DEB therapeutic AKP randomized controlled trial. Develop criteria for documentation inclusion and exclusion, evaluate the quality and bias risk of literature, and compare differences in efficacy and adverse responses before and after DEB treatment and other conservative treatments. Results. A total of 14 randomized controlled trials and 1464 AKP patients were included in the study, with follow-up duration of 1-12 months. The total knee scores for DEB at 1, 3, 6, and 12 months after treatment were significantly better than baseline levels (1 month: WMD = 34.56 , P = 0.02 ; 3 months: WMD = 27.73 , P = 0.0001 ; 6 months: SMD = 2.38 , P = 0.0001 ; 12 months: SMD = 1.69 , P = 0.001 ). At 6 months of follow-up, DEB improved knee function better than HA ( SMD = 0.47 , P = 0.003 ), and during follow-up for 12 months, DEB relieved knee pain ( SMD = 0.55 , P = 0.0007 ) and improved knee function ( SMD = 0.88 , P = 0.0001 ) which is significantly better than HA. DEB was less effective at improving knee function in 1, 3, and 12 months than DEB joint HA injections (1 month P = 004 ; 3 months P = 0.01 ; 12 months P = 0.03 ). At 6 and 12 months of follow-up, DEB was better at pain relief and improved function than ozone ( P > 0.05 ). DEB and glucocorticosteroids have similar effects in pain relief and improved function at various follow-up times. In terms of adverse reactions, DEB does not increase the risk of adverse events compared to HA ( OR = 0.96 , P = 0.85 ). Conclusion. Compared to HA and ozone, DEB is a more effective treatment for AKP joints, while DEB is combined with HA. The clinical efficacy of injection therapy AKP is better than that of DEB alone.

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Section: Methods In Treating Akpmentioning

confidence: 99%