Effectiveness of Varicella Vaccination Program in Preventing Laboratory-Confirmed Cases in Children in Seoul, Korea

Lee, Young Hwa; Choe, Young June; Cho, Sung-Il; Kang, Cho Ryok; Bang, Ji Hwan; Oh, Myoung Don; Lee, Jong koo

doi:10.3346/jkms.2016.31.12.1897

Cited by 30 publications

(47 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decreasing trend of antibody level may explain the continuing increase of varicella in all given cohorts despite the introduction of the vaccine into the national immunisation programme. According to Lee et al [27], varicella vaccine effectiveness in Korea sharply declined after the third year of vaccination. Considering Korea's high rate of vaccine coverage, most of the varicella incidence is associated with a breakthrough case.…”

Section: Epidemiology and Infectionmentioning

confidence: 99%

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

et al. 2019

Self Cite

View full text Add to dashboard Cite

In the Republic of Korea, despite the introduction of one-dose universal varicella vaccination in 2005 and achieving a high coverage rate of 98.9% in 2012, the incidence rate has been increased sevenfold. This study aimed to investigate time trends of varicella incidence rate, assessing the age, period and birth cohort effects. We used national data on the annual number of reported cases from 2006 to 2017. A log-linear Poisson regression model was used to estimate age–period–cohort effects on varicella incidence rate. From 2006 to 2017, the incidence of varicella increased from 22.5 cases to more than 154.8 cases per 100 000. Peak incidence has shifted from 4 to 6 years old. The estimated period and cohort effects showed significant upward patterns, with a linear increasing trend by net drift. There has been an increase in the incidence among the Korean population regarding period and cohort despite the universal vaccination of varicella vaccine. Our data suggest the need for additional studies to address the current gap in herd immunity.

show abstract

Section: Epidemiology and Infectionmentioning

confidence: 99%

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…VE was higher against moderate or severe disease, ranging from 70% to 98% after one dose and 94% to 98% after two doses [23,47]. Two studies from Israel [48] and Korea [49] recorded much lower VE – in case of Israel, this was most probably due to the very low coverage (37%) [48] and in the case of Korea was due to the ineffectiveness of one of the administered vaccines [49]. With these exceptions, the ranges shown are consistent with previous reviews [50,51].…”

Section: Evidence For Varicella Vaccinationmentioning

confidence: 99%

Varicella vaccination - the global experience

Wutzler

Bonanni

Burgess

et al. 2017

Expert Review of Vaccines

140

View full text Add to dashboard Cite

Introduction Varicella, although a frequently benign childhood disease, nevertheless represents a considerable health burden. WHO recommends including varicella vaccines in universal routine vaccination programs, and maintaining coverage >80%. Many countries have successfully introduced varicella vaccination and have benefited from lower disease burden, but many others have not adopted the vaccine. Reasons include cost commitment for a ‘mild childhood disease’ or concerns that vaccination will shift varicella to older age groups or increase herpes zoster incidence. Areas covered This literature review summarizes the effectiveness and epidemiological impact of varicella immunization programs. Expert commentary Varicella vaccines are immunogenic with acceptable safety profiles. One and two dose schedules are highly effective against varicella and large reductions in disease incidence, particularly moderate-severe disease, have been widely reported. There is currently no evidence to suggest that the introduction of varicella vaccination results in a shift of varicella disease burden to older age groups. Although epidemiological studies have shown an increased incidence of herpes zoster since the vaccines were launched, there are many other contributing factors, and indeed, this secular trend was evident before their introduction. In conclusion, varicella vaccination easily fits into existing immunization programs and significantly reduces the often underestimated burden of varicella.

show abstract

“…These findings suggest that adults in the tropical countries maybe at high risk for acquiring VZV infection due to late sero-conversion to anti-VZV IgG and thus experiencing morbidity and a mortality rate of up to15.0% [11]. Based on a recent South Korean study, incorporating the universal varicella vaccine to the National Immunization Programme since 2005 has not decreased the incidence of varicella, 22.5 per 100,000 persons in 2006 to 73.2 per 100,000 persons in 2013 [12]. However, a difference in the anti-VZV IgG sero-prevalence rate is noticeable even among different tropical countries.…”

Section: Introductionmentioning

confidence: 99%

Exposure rate of VZV among women attending antenatal care clinic in Sri Lanka - a cross sectional study

et al. 2017

View full text Add to dashboard Cite

BackgroundVaricella or chickenpox was not a notifiable disease until 2005 in Sri Lanka and only a few studies have been conducted on the epidemiology of VZV infection in the country. The antiVZV IgG sero-prevalence among antenatal women is extremely limited and thus a selected group of antenatal clinic attendees were chosen to determine the exposure rate to VZV infection.MethodsWomen attending the antenatal clinic at Teaching Hospital, Peradeniya, Sri Lanka were selected for the study and 3 mL of venous blood was collected from 181 participants and the demographic data was obtained through a pretested questionnaire. Sera of the women were then tested for the presence of antiVZV IgG using ELISA (HUMAN Diagnostics, Germany). Data was analysed using the SPSS statistical software for Windows, Version 12.0.ResultsOf the 181 antenatal women who took part in the study, 141 were positive for antiVZV IgG giving a sero-prevalence of 77.9% for the past exposure to VZV. Of the 141 antiVZV IgG positive women, 43.3% (n = 61) were from urban, 41.8% (n = 59) were from rural and 14.9% (n = 21) were from estate populations (an ethnic population living in small settlements in the tea estates whose ancestors were brought from India during the British colonial period to work in the tea plantations in Sri Lanka). Out of the 88 antenatal women with a positive history for varicella, 85 (96.6%) were positive for anti-VZV IgG. The highest number of antiVZV IgG positivity was seen in the 31–35 age group, which was 85.0% of the total number of antenatal women included in that category. An increase in the antiVZV IgG sero-prevalence with increasing age was also noted in the study sample.ConclusionExposure rate of VZV infection as confirmed by antiVZV IgG in the present study sample of antenatal women was 77.9%. Age specific, population based future sero-prevalence studies should be conducted in Sri Lanka to understand the anti-VZV IgG status in the country.

show abstract

Effectiveness of Varicella Vaccination Program in Preventing Laboratory-Confirmed Cases in Children in Seoul, Korea

Cited by 30 publications

References 18 publications

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

Varicella vaccination - the global experience

Exposure rate of VZV among women attending antenatal care clinic in Sri Lanka - a cross sectional study

Contact Info

Product

Resources

About