Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis

Abstract

The data suggest that infliximab may provide an effective and more specific therapeutic option in the treatment of active WG refractory to standard treatment.

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

“…Of interest, CD11cϩ spleen cells transferred arthritis resistance to naive recipients. These findings raise the possibility that suppressive ODNs might be useful for the prevention/ treatment of inflammatory arthritis and other rheumatic diseases, particularly those exacerbated by TNF␣ (33,34).…”

Refractory Primary Central Nervous System Vasculitis of Childhood: Successful Treatment with Infliximab

“…Prompt resolution of symptoms was seen. The efficacy of anti-TNF therapy was also demonstrated in case series of adult vasculitides including Takayasu arteritis and Wegener granulomatosis 7,8 . Similarly, IFX led to cessation of fever in 81% of children with refractory Kawasaki disease 4 .…”

Novel Strategy for the Treatment of Refractory Vasculitis Syndrome

“…However, 4 open pilot studies have been reported along with case reports suggestive of its usefulness. [6][7][8][9] Of the 54 cases included in the 4 reports, 35 had Wegener's granulomatosis, and 16 had microscopic polyangiitis. Thirty-seven of the 54 cases were refractory cases in which remission could not be induced by a standard immunosuppressive therapy.…”