Effectiveness of the use of urease inhibitors in agriculture: a review

Matczuk, Dominika; Siczek, Anna

doi:10.31545/intagr/139714

Cited by 31 publications

(26 citation statements)

References 74 publications

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“…Comparison to the hydrolysis of urea in the presence and absence of urease demonstrated that this enzyme accelerates conversation urea to ammonia and carbon dioxide by at least 1014 over the spontaneous reaction [3] . The enzymatic activity of urease leads to an increase in pH due to an increase in ammonia concentration that has various negative effects in medicine and agriculture [4–6] . Treatment effects of urease inhibitors in some diseases are well documented [7–10] .…”

Section: Introductionmentioning

confidence: 99%

Rational Design, Synthesis, Docking Simulation, and ADMET Prediction of Novel Barbituric‐hydrazine‐phenoxy‐1,2,3‐triazole‐acetamide Derivatives as Potent Urease Inhibitors

Hosseinzadeh

Montazer

Mohammadi‐Khanaposhtani

et al. 2023

ChemistrySelect

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Urease is an important target for the treatment of Helicobacter pylori infection. In this study, several pharmacophores for the inhibition of urease were considered and coupled to design new molecules capable of acting as potent urease inhibitors. Literature review reveals that barbituric-hydrazine, phenoxy-1,2,3-triazole, and acetamide moieties are pharmacophores for urease inhibition. Therefore, in this study, the barbiturichydrazine-phenoxy-1,2,3-triazole-acetamide scaffold was designed and twelve derivatives 9 a-l of it were synthesized and evaluated. The urease inhibition assay of these compounds revealed that all new title compounds, except for one compound, with IC 50 values of 0.73 to 5.27 μM were more potent than standard inhibitor thiourea. The most potent compound inhibited urease in a mixed-type inhibition mode and interacted as well with the urease active site. In silico druglikeness and toxicity studies of the most potent compounds predicted that these compounds passed successfully Lipinski's rule of five and had no carcinogenicity on the rat.

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Section: Introductionmentioning

confidence: 99%

Rational Design, Synthesis, Docking Simulation, and ADMET Prediction of Novel Barbituric‐hydrazine‐phenoxy‐1,2,3‐triazole‐acetamide Derivatives as Potent Urease Inhibitors

Hosseinzadeh

Montazer

Mohammadi‐Khanaposhtani

et al. 2023

ChemistrySelect

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“…Bunu önlemek amacıyla tarımda N-(n-butil) tiyofosforik triamit (NBPT) gibi üreaz inhibitörleri kullanılmaktadır. 6 Dolayısıyla yeni üreaz inhibitörlerinin keşfi, bu alandaki kullanım için de önemli bir alternatif olabilecektir.…”

Section: Introductionunclassified

Rize’den Toplanan Altı Bitkinin İn Vitro Üreaz İnhibe Edici ve Antioksidan Aktivitesi

DİLMAÇ

SUCU

Günbatan

et al. 2023

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi

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Giriş ve amaç: Üreaz enzimi, Helicobacter pylori nedenli peptik ülserin tedavisi için yeni ilaç adayı bileşiklerin hedeflerinden biri haline gelmiştir. Bu çalışmada Rize’den toplanan altı yabani bitkinin [Daphne pontica L., Lotus corniculatus L., Lythrum salicaria L., Medicago sativa L., Potentilla reptans L. ve Senecio leucanthemifolius subsp. vernalis (Waldst. & Kit.) Greuter] üreaz enzimini inhibe edici aktivitesinin belirlenmesi amaçlanmıştır. Bununla birlikte peptik ülserin önlenmesinde rol oynayan mekanizmalardan biri olan antioksidan aktiviteleri belirlenmiş, toplam fenol ve flavonoit içerikleri de tespit edilmiştir. Yöntem: Bitkiler Rize Merkez ve İkizdere ilçesinden toplanıp %80’lik etanol ekstreleri hazırlanmış ve üreaz enzimini inhibe edici aktiviteleri belirlenmiştir. Hazırlanan ekstrelerin antioksidan aktivitesi DPPH, ABTS ve CUPRAC testleri ile tespit edilmiş, toplam fenol ve flavonoit miktar tayinleri yapılmıştır.Bulgular: İn vitro testler sonucunda S. leucanthemifolius subsp. vernalis’in %80 etanol ekstresi üreaz enzimini düşük oranda inhibe ederken (%13,7) diğer çalışılan ekstrelerin daha kuvvetli (% 24,6 ve %31,3 arasında değişen oranlarda) inhibe ettiği görülmüştür. Çalışılan ekstrelerin genel olarak kuvvetli antioksidan aktiviteye sahip olduğu belirlenmiştir. En yüksek toplam fenol ve flavonoit içerikleri sırasıyla L. salicaria ve L. corniculatus’da tespit edilmiştir.Sonuç: Çalışmaya dâhil edilen bitkilerin genel olarak üreaz enzimini belirli bir düzeyde inhibe ettiği belirlenmiştir. D. pontica, L. salicaria ve P. reptans yüksek antioksidan aktivite, toplam fenol ve flavonoit içerikleri ile öne çıkmıştır.

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“…Thus, endogenous enzyme inhibitors result in effective defensive immune or anti-predatory mechanisms against such molecular weapons [ 9 , 10 ]. Consequently, natural enzyme inhibitors have received notorious attention as a research subject and have found numerous biomedical [ 11 , 12 ], industrial [ 13 ], and environmental applications [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Enzyme Inhibitors from Gorgonians and Soft Corals

et al. 2023

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For decades, gorgonians and soft corals have been considered promising sources of bioactive compounds, attracting the interest of scientists from different fields. As the most abundant bioactive compounds within these organisms, terpenoids, steroids, and alkaloids have received the highest coverage in the scientific literature. However, enzyme inhibitors, a functional class of bioactive compounds with high potential for industry and biomedicine, have received much less notoriety. Thus, we revised scientific literature (1974–2022) on the field of marine natural products searching for enzyme inhibitors isolated from these taxonomic groups. In this review, we present representative enzyme inhibitors from an enzymological perspective, highlighting, when available, data on specific targets, structures, potencies, mechanisms of inhibition, and physiological roles for these molecules. As most of the characterization studies for the new inhibitors remain incomplete, we also included a methodological section presenting a general strategy to face this goal by accomplishing STRENDA (Standards for Reporting Enzymology Data) project guidelines.

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Effectiveness of the use of urease inhibitors in agriculture: a review

Cited by 31 publications

References 74 publications

Rational Design, Synthesis, Docking Simulation, and ADMET Prediction of Novel Barbituric‐hydrazine‐phenoxy‐1,2,3‐triazole‐acetamide Derivatives as Potent Urease Inhibitors

Rational Design, Synthesis, Docking Simulation, and ADMET Prediction of Novel Barbituric‐hydrazine‐phenoxy‐1,2,3‐triazole‐acetamide Derivatives as Potent Urease Inhibitors

Rize’den Toplanan Altı Bitkinin İn Vitro Üreaz İnhibe Edici ve Antioksidan Aktivitesi

Enzyme Inhibitors from Gorgonians and Soft Corals

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