Prohexadione–calcium (ProCa) is used routinely in orchards to control vegetative growth and to reduce the shoot blight phase of fire blight. This communication reports on multiple-year applications of ProCa with special emphasis on treatment effects on fruit set, fruit size, and return bloom. Increased fruit set was confirmed from high rates of ProCa above 125 mg·L−1. The increase in fruit set was attributed primarily to a reduction of abscission during June drop rather than an increase in initial set. ProCa decreased fruit weight in some instances. Part of this reduction could be attributed to increased fruit set. However, the large reduction in fruit weight at harvest could only be explained by a direct effect of ProCa when used at high rates. When ProCa was applied as a concentrate spray at 250 mg·L−1, terminal growth was reduced comparable to the application made as a tree row volume dilute spray (1×). However, fruit set was increased when the spray volume in which ProCa was delivered was reduced to 4×. A range of ProCa rates was used on ‘Mutsu’. An initial application rate of 42 mg·L−1 followed by similar subsequent rates controlled growth comparably to higher initial and total rates, yet low rates had no effect on fruit weight or return bloom. Low rates of ProCa appear to be effective at controlling vegetative growth yet appear to have minimal side effects. High rates, especially those intended to reduce fire blight, come with the risk of increased fruit set and reduced fruit size and return bloom.