Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Schröder, Helmut; Cárdenas-Fuentes, Gabriela; Martínez‐González, Miguel Ángel; Corella, Dolores; Vioque, Jesús; Romaguera, Dora; Martínez, J. Alfredo; Tinahones, Francisco J.; López‐Miranda, José; Estruch, Ramón; Bueno‐Cavanillas, Aurora; Arós, Fernando; Marcos, Ascensión; Tur, Josep A.; Wärnberǵ, Julia; Serra‐Majem, Lluís; Martín, Vicente; Vázquez, Clotilde; Lapetra, José; Pintó, Xavier; Vidal, Josep; Daimiel, Lidia; Gaforio, José J.; Matía‐Martín, Pilar; Ros, Emilio; Castañer, Olga; Lassale, Camille; Ruiz‐Canela, Miguel; Asensio, Eva M.; Basora, Josep; Torres-Collado, Laura; García‐Rios, Antonio; Abete, Itziar; Toledo, Estefanía; Buil‐Cosiales, Pilar; Bulló, Mònica; Goday, Albert; Fitó, Montserrat; Salas‐Salvadó, Jordi

doi:10.1186/s12966-018-0741-x

Cited by 34 publications

(20 citation statements)

References 32 publications

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“…Type-2 diabetes was defined as previous clinical diagnosis of diabetes, HbA1c levels ≥ 6.5%, or use of anti-diabetic medication [59]. Leisure-time physical activity was assessed using the validated REGICOR questionnaire [60,61], including questions to collect information on the type of activity, frequency (number of days), and duration. The total leisure-time physical activity-related energy expenditure was estimated as the summed product of frequency, duration, and intensity of each activity divided by 30 days/month (MET·min/day).…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

et al. 2019

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Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is a powerful antioxidant and suggest that slightly increased serum bilirubin concentrations are protective against oxidative stress-related diseases, such as cardiovascular diseases. Therefore, a better understanding of the gene-diet interactions in determining serum bilirubin concentrations is needed. None of the previous genome-wide association studies (GWAS) on bilirubin concentrations has been stratified by sex. Therefore, considering the increasing interest in incorporating the gender perspective into nutritional genomics, our main aim was to carry out a GWAS on total serum bilirubin concentrations in a Mediterranean population with metabolic syndrome, stratified by sex. Our secondary aim was to explore, as a pilot study, the presence of gene-diet interactions at the GWAS level. We included 430 participants (188 men and 242 women, aged 55–75 years, and with metabolic syndrome) in the PREDIMED Plus-Valencia study. Global and sex-specific GWAS were undertaken to analyze associations and gene-diet interaction on total serum bilirubin. Adherence (low and high) to the Mediterranean diet (MedDiet) was analyzed as the dietary modulator. In the GWAS, we detected more than 55 SNPs associated with serum bilirubin at p < 5 × 10−8 (GWAS level). The top-ranked were four SNPs (rs4148325 (p = 9.25 × 10−24), rs4148324 (p = 9.48 × 10−24), rs6742078 (p = 1.29 × 10−23), rs887829 (p = 1.39 × 10−23), and the rs4148324 (p = 9.48 × 10−24)) in the UGT1A1 (UDP glucuronosyltransferase family 1 member A1) gene, which replicated previous findings revealing the UGT1A1 as the major locus. In the sex-specific GWAS, the top-ranked SNPs at the GWAS level were similar in men and women (the lead SNP was the rs4148324-UGT1A1 in both men (p = 4.77 × 10−11) and women (p = 2.15 × 10−14), which shows homogeneous genetic results for the major locus. There was more sex-specific heterogeneity for other minor genes associated at the suggestive level of GWAS significance (p < 1 × 10−5). We did not detect any gene-MedDiet interaction at p < 1 × 10−5 for the major genetic locus, but we detected some gene-MedDiet interactions with other genes at p < 1 × 10−5, and even at the GWAS level for the IL17B gene (p = 3.14 × 10−8). These interaction results, however, should be interpreted with caution due to our small sample size. In conclusion, our study provides new data, with a gender perspective, on genes associated with total serum bilirubin concentrations in men and women, and suggests possible additional modulations by adherence to MedDiet.

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Section: Methodsmentioning

confidence: 99%

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

et al. 2019

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“…Previous reported results of the PREDIMED-Plus physical activity intervention program showed effective increasing of physical activity after one-year of a physical activity intervention program [15].…”

Section: Physical Activity Interventionmentioning

confidence: 85%

“…The PREvención con DIeta MEDiterránea (PREDIMED)-Plus study, an ongoing multicenter randomized trial primary designed to evaluate the long-term impact of an intensive lifestyle intervention on cardiovascular events, recently published the effectiveness of the physical activity intervention component. This secondary analysis showed promising individual-level effectiveness in the increment of physical activity after one-year of a lifestyle intervention program for older overweight/obese participants with metabolic syndrome [15].…”

Section: Introductionmentioning

confidence: 87%

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Moderation Effect of Neighborhood Walkability during a Physical Activity Intervention in Overweight and Obese Elderly Subjects with Metabolic Syndrome.

Fernández¹,

Mavoa²,

Ruiz³

et al. 2019

Preprint

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Background: An infrequently studied question is how the objective measurement of neighborhood walkability modulates physical activity changes during a physical activity intervention program in older adults. We assessed the influence of objectively assessed neighborhood walkability inside the city limits of Palma de Mallorca on the change in physical activity during the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, a multicenter randomized trial primarily designed to evaluate the long-term impact of an intensive lifestyle intervention on cardiovascular events. Method: The present study involved 228 PREDIMED-Plus senior participants aged between 55 to 75, recruited in Palma de Mallorca (Spain). Overweight/obese adults with the metabolic syndrome were randomized to an intensive weight-loss lifestyle intervention or a control group. A walkability index was calculated within 1 km buffers around each participant’ baseline home address. Physical activity was assessed using the validated REGICOR Short Physical Activity Questionnaire and accelerometer, at baseline and at 2 follow-up visits (six-months and one-year later). Generalised Additive Mixed Models (GAMMs) were fitted to estimate the association between the neighborhood walkability index and changes in physical activity during follow-up in both the intervention and control group. Results: After one-year of intervention, higher neighborhood walkability (1 z-score increment) was positively and significantly associated with moderate-to-vigorous accelerometer assessed physical activity duration, (ß = 3,44; 95% CI = 0.52;6.36 minutes per day). When analyses were stratified by intervention arm, the association was only significant in the intervention group (ß = 6.357; 95% CI = 2.07;10.64 minutes per day) (p for interaction = 0.055). There were no statistically significant associations between neighborhood walkability and self-reported leisure-time physical activity nor brisk walking duration. Conclusions: The results indicate that the walkability of the neighborhood could support a physical activity intervention, helping to maintain or increase older adults’ physical activity.

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“…The short time period during which the patient with myocardial infarction treated interventional is hospitalized is extremely important for understanding the cardiovascular risk factors that have led to the development of the disease and for implementing lifestyle changing measures, including those concerning a healthy diet. Next, although rehabilitation is carried out in an outpatient setting (and currently, more and more often at home), the patient should be monitored and evaluated periodically from this point of view as well (16)(17)(18). In this regard, creating a "nutritional model" that can be applied to these categories of patients can be of real help.…”

Section: Preliminary Results Stage I -Based On the Data Provided By Umentioning

confidence: 99%

Collaborative platform development in nutrition as support for cardiovascular patients’ rehabilitation

Sitar‐Tăut

Sitar-Tăut

Mican

et al. 2019

BALNEO

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Introduction. Enrollment of patients with cardiovascular disease in rehabilitation programs may contribute to implementation of a healthy lifestyle, including by promotion of a diet adequate for each patient’s profile. In this context, the current study is aimed at creating a traffic light system model allowing to obtain the development, innovation and diversification of menus and to improve the nutritional programs for this category of patients. Material and method. Based on the data provided by USDA Food Composition Databases, the composition in terms of different nutritive principles was determined for each ingredient and for each final menu. Comparison of menus depending on each nutritive principle, as well as comparison between menus and nutrient requirements according to indications for patients attending cardiovascular rehabilitation programs was made. Results. The traffic light system was developed, using color codes, comparing daily nutrient requirements with preparations’ content. Conclusions. The major benefit of the traffic light system would reside in the fact that starting from classic menus, an intervention on these can be achieved, and healthier, more nutritionally balanced models can be created, according to healthy nutrition principles. These new menus will be calorically and nutritionally adapted for patients attending cardiovascular rehabilitation programs. Key words: nutrition, rehabilitation, traffic light system,

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Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Cited by 34 publications

References 32 publications

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

Moderation Effect of Neighborhood Walkability during a Physical Activity Intervention in Overweight and Obese Elderly Subjects with Metabolic Syndrome.

Collaborative platform development in nutrition as support for cardiovascular patients’ rehabilitation

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