Effectiveness of the male latex condom: combined results for three popular condom brands used as controls in randomized clinical trials

Walsh, Terri; Frezieres, Ron G.; Peacock, Karen; Nelson, Anita L.; Clark, Virginia A.; Bernstein, Leslie; Wraxall, B.G.D.

doi:10.1016/j.contraception.2004.05.008

Cited by 39 publications

(15 citation statements)

References 16 publications

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“…Condoms also provided high contraceptive efficacy, especially when used consistently. 23 Another study found that the male and female condom failure rate decreased among women at high risk of STIs from 20% at first use to 1.2% after 15 uses of the female condom and from 9% at first use to 2.3% after 15 uses for the male condom. 24 Thus, a bit of practice is the main thing that is needed.…”

Section: Diverse Forms Of Dual Protection For Diverse People and Needsmentioning

confidence: 98%

Dual Protection: More Needed than Practised or Understood

Berer¹

2006

Reproductive Health Matters

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Section: Diverse Forms Of Dual Protection For Diverse People and Needsmentioning

confidence: 98%

Dual Protection: More Needed than Practised or Understood

Berer¹

2006

Reproductive Health Matters

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“…Breakage, slippage, leakage or 'condom failure' 9,16,17,20,21,24,26,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] Studies have reported on slippage in a variety of ways, sometimes specifying timing (during intercourse or upon withdrawal) and sometimes specifying degree of slippage (complete or partial); most of the reports, however, did not specify either of these. It is worth noting that slippage during withdrawal may reflect the user error of not holding the rim of the condom during withdrawal.…”

Section: -15mentioning

confidence: 99%

“…Estimates for slippage during intercourse ranged from 13.1% to 19.3% of participants in three studies [13][14][15] and from 0.0% to 6.6% for condom use events across five additional studies. 20,22,36,40,42 Estimates for slippage during withdrawal ranged from 11.6% to 14.9% of participants in three studies [13][14][15] and from 0.0% to 12.8% of events in four other studies. 20,21,36,42 For studies which did not specify timing of slippage, the range of estimates was 0.8% 31 to 36.2% 27 of participants across eight studies.…”

Section: -15mentioning

confidence: 99%

Condom use errors and problems: a global view

et al. 2012

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Abstract. Background: Significantly more research attention has been devoted to the consistency of condom use, with far fewer studies investigating condom use errors and problems. The purpose of this review was to present the frequency of various condom use errors and problems reported worldwide. Methods: A systematic literature search was conducted for peer-reviewed articles, published in English-language journals between 1995 and 2011. Results: Fifty articles representing 14 countries met criteria for inclusion. The most common errors included not using condoms throughout sex, not leaving space at the tip, not squeezing air from the tip, putting the condom on upside down, not using water-based lubricants and incorrect withdrawal. Frequent problems included breakage, slippage, leakage, condom-associated erection problems, and difficulties with fit and feel. Prevalence estimates showed great variation across studies. Prevalence varied as a function of the population studied and the period assessed. Conclusion: Condom use errors and problems are common worldwide, occurring across a wide spectrum of populations. Although breakage and slippage were most commonly investigated, the prevalence of other condom use errors and problems found in this review were substantially higher. As a framework for understanding the role of condom errors and problems in inadequate protection, we put forward a new model: the Condom Use Experience model. This model can be used to generate testable hypotheses for future research. Addressing condom use errors and problems in research and interventions is crucial to closing the gap between the perfect use and typical use of condoms.Additional keywords: condom breakage, condom slippage, sexual behaviour, sexually transmissible infections.

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“…Objective biomarkers of semen exposure, most notably prostate-specific antigen (PSA), are valid predictors of exposure to semen and may offer a reliable counterpart to user self-report for assessing condom performance during penile-vaginal intercourse [1]. An increasing number of clinical trials have incorporated testing for PSA levels to assess the performance of male and female condoms [2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Prostate-specific antigen as a biomarker of condom failure: comparison of three laboratory assays and self-reported condom use problems in a randomized trial of female condom performance

et al. 2012

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Background-Prostate-specific antigen (PSA), a biomarker for semen exposure, may provide a more objective measure of condom failure than subject self-reports. Methods for measuring PSA vary and their comparability with respect to assessing condom performance has not been adequately evaluated. This study compared results from three different PSA assays of vaginal samples collected by subjects in a randomized clinical trial which compared the performance of female condoms.Study Design-We selected 30 pairs of pre-and post-coital vaginal samples from subjects who reported condom functionality problems or whose original PSA assay was positive. Samples were retested using three different PSA assays [quantitative enzyme-linked immunoassay (EIA), rocket immune-electrophoresis (RIE) and chromatographic immunoassay (CIA)]. We compared the proportion of condom uses where the post-coital PSA result indicated semen exposure for each of the three assays.Results-Despite varying levels of sensitivity, the results from all three assays were remarkably consistent. Self-reported condom failures did not correlate well with positive PSA results, suggesting that exclusive reliance on either PSA or user self-report may be inadequate for assessing condom functionality. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptConclusion-In combination with user self-report of condom failure, PSA testing provides a reliable, objective marker of condom functionality. Studies based on PSA testing may improve on conventional contraceptive clinical trials by offering a more direct assessment of a condom product's ability to prevent semen exposure.

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Effectiveness of the male latex condom: combined results for three popular condom brands used as controls in randomized clinical trials

Cited by 39 publications

References 16 publications

Dual Protection: More Needed than Practised or Understood

Dual Protection: More Needed than Practised or Understood

Condom use errors and problems: a global view

Prostate-specific antigen as a biomarker of condom failure: comparison of three laboratory assays and self-reported condom use problems in a randomized trial of female condom performance

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