Effectiveness of the levonorgestrel-releasing intrauterine system in the treatment of adenomyosis diagnosed and monitored by magnetic resonance imaging

Levonorgestrel-releasing intrauterine system versus a low-dose combined oral contraceptive for treatment of adenomyotic uteri: a randomized clinical trial

“…ACCEPTED MANUSCRIPT 11 The suggestion of using LNG-IUS was based on its ability to down-regulate estrogen receptors (ER) in endometrial tissues and its decidualization with subsequent atrophy of the endometrium [12]. In addition, the LNG-IUS has a pain-relieving effect through the reduction of prostaglandin production within the endometrium and induction of adenomyosis foci atrophy [13].…”

“…The LNG-IUS group received LNG-IUS (Mirena; Bayer Schering Healthcare AG, Bayer HealthCare, Berlin, Germany), inserted according to the manufacturer's instructions [12]. TVS ascertained proper insertion of the device immediately after insertion.…”

Using Contraceptives for Gynecologic Conditions

“…Over 70 % of women were satisfi ed with their treatment. Another study enrolled 29 women to receive the LNG-IUD who reported heavy, painful menses and had MRI fi ndings of adenomyosis and followed subjects over time for changes in bleeding pattern and menstrual pain scores [ 6 ]. Heavy menses resolved in all 29 women, with 2 reporting regular menses with normal fl ow, 10 reporting unpredictable spotting, 9 reporting oligomenorrhea, and 8 reporting amenorrhea 6 months after insertion.…”

Long-Term Efficacy of Laparoscopic or Robotic Adenomyomectomy with or without Medical Treatment for Severely Symptomatic Adenomyosis

“…The effects of medical treatments, such as progestin, oral contraceptives or GnRH agonists are transient [3]. Recent studies have demonstrated that levonorgestrel-releasing intrauterine devices are effective for the management of adenomyosis in women with dysmenorrhea and menorrhagia [16,17]. However, the adverse effects of prolonged exposure to progestin treatment, such as headache, breast tenderness, seborrhea, acne and weight gain, may diminish long-term patient satisfaction [18].…”