Effectiveness of the influenza vaccine in preventing admission to hospital and death in people with type 2 diabetes

Vámos, Eszter; Pape, Utz Johann; Ćurčin, Vasa; Harris, Matthew; Valabhji, Jonathan; Majeed, Azeem; Millett, Christopher

doi:10.1503/cmaj.151059

Cited by 93 publications

(77 citation statements)

References 29 publications

(41 reference statements)

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“…Another study demonstrated that influenza vaccination, apart from reducing the risk of influenza and its complications, was associated with lower hospital admission rates: 15% for pneumonia or influenza, 19% for acute myocardial infarction, 22% for heart failure and 30% for stroke. the study also revealed a 24% lower all-cause mortality in vaccinated vs nonvaccinated patients [32]. A study conducted in the netherlands during the 1999-2000 influenza A epidemic in a population of adults with diabetes found that vaccination was associated with a 56% reduction in any complication, a 54% reduction in hospitalizations, and a 58% reduction in deaths [33].…”

Section: Patients With Diabetes Mellitusmentioning

confidence: 83%

Recommendations for the prevention, diagnosis and treatment of inFLUenza in adults for Primary care physiciAnS: FLU COMPAS PCP – ADULTS

Mastalerz-Migas¹,

Kuchar²,

Nitsch–Osuch³

et al. 2020

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influenza is an acute infectious disease of viral etiology which, unlike the common cold, can lead to serious complications such as pneumonia, myocarditis, inflammation of the kidneys, nervous system, and muscles, and even death. Vaccination is the most effective method of preventing influenza and should be recommended to everyone over six months of age, with particular emphasis on risk groups. When the symptoms of influenza occur, the only drugs recommended for curative treatment are neuraminidase inhibitors (of which only oseltamivir is available in Poland). influenza diagnosis of should be made during the epidemic season based on clinical signs. Only curative treatment should be employed in risk groups. treatment should not be delayed in order to wait for the results of tests confirming infection.

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Section: Patients With Diabetes Mellitusmentioning

confidence: 83%

Recommendations for the prevention, diagnosis and treatment of inFLUenza in adults for Primary care physiciAnS: FLU COMPAS PCP – ADULTS

Mastalerz-Migas¹,

Kuchar²,

Nitsch–Osuch³

et al. 2020

fmpcr

View full text Add to dashboard Cite

show abstract

“…After adding 2 studies identified through manual searches, a total of 11 studies were included in the final analysis. Of 3 studies sampled from the United Kingdom General Practice Research Database, 2 studies included overlapping groups of participants [22,23]; we used data from each study in overall and subgroup analyses as appropriate.…”

Section: Resultsmentioning

confidence: 99%

Effect of Influenza Vaccination on Risk of Stroke: A Systematic Review and Meta-Analysis

et al. 2017

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Background: Despite the presence of a strong association between influenza infection and stroke, whether influenza vaccination reduces the risk of stroke is yet a matter of controversy. We conducted a meta-analysis to determine whether influenza vaccination protects against stroke. Methods: We searched PubMed, EMBASE, and the Cochrane Library from database inception date to November 18, 2016, without language restrictions, to identify studies investigating the effect of influenza vaccination on subsequent risk of stroke. We conducted a meta-analysis to quantify the risk of stroke in overall and subgroup analyses and calculated a pooled OR for developing stroke with a 95% CI. Publication bias was assessed by Begg's rank correlation test. Results: Eleven studies fulfilled our inclusion criteria. In a random-effects model, vaccinated individuals had a decreased risk of stroke compared with unvaccinated individuals (OR 0.82; 95% CI 0.75-0.91; p < 0.001). The relationship between influenza vaccination and stroke risk remained robust in subgroup analyses. The significant effect of influenza vaccination was associated with ascertainment of vaccination status and stage of prevention. Conclusion: Vaccination against influenza is associated with a lower risk of stroke. Well-designed prospective studies are needed to provide stronger evidence of the protective effect of influenza vaccination against stroke.

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“…As a secondary prevention measure, anti-influenza vaccination may be considered in type 2 diabetic patients with a higher predisposition to cardiovascular diseases [40]. Notably, admissions for HF were significantly reduced in the flu season in vaccine recipients compared to those who did not receive the vaccine.…”

Section: Anti-influenza Vaccination and Heart Failurementioning

confidence: 99%

Influenza infection and heart failure—vaccination may change heart failure prognosis?

et al. 2017

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The interaction of influenza infection with the pathogenesis of acute heart failure (AHF) and the worsening of chronic heart failure (CHF) is rather complex. The deleterious effects of influenza infection on AHF/CHF can be attenuated by specific immunization. Our review aimed to summarize the efficacy, effectiveness, safety, and dosage of anti-influenza vaccination in HF. In this literature review, we searched MEDLINE and EMBASE from January 1st 1966 to December 31st, 2016, for studies examining the association between AHF/CHF, influenza infections, and anti-influenza immunizations. We used broad criteria to increase the sensitivity of the search. HF was a prerequisite for our search. The search fields used included “heart failure,” “vaccination,” “influenza,” “immunization” along with variants of these terms. No restrictions on the type of study design were applied. The most common clinical scenario is exacerbation of pre-existing CHF by influenza infection. Scarce evidence supports a potential positive association of influenza infection with AHF. Vaccinated patients with pre-existing CHF have reduced all-cause morbidity and mortality, but effects are not consistently documented. Immunization with higher antigen quantity may confer additional protection, but such aggressive approach has not been generally advocated. Further studies are needed to delineate the role of influenza infection on AHF/CHF pathogenesis and maintenance. Annual anti-influenza vaccination appears to be an effective measure for secondary prevention in HF. Better immunization strategies and more efficacious vaccines are urgently necessary.

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Effectiveness of the influenza vaccine in preventing admission to hospital and death in people with type 2 diabetes

Cited by 93 publications

References 29 publications

Recommendations for the prevention, diagnosis and treatment of inFLUenza in adults for Primary care physiciAnS: FLU COMPAS PCP – ADULTS

Recommendations for the prevention, diagnosis and treatment of inFLUenza in adults for Primary care physiciAnS: FLU COMPAS PCP – ADULTS

Effect of Influenza Vaccination on Risk of Stroke: A Systematic Review and Meta-Analysis

Influenza infection and heart failure—vaccination may change heart failure prognosis?

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