Background: Metabolic risk factors contributing are abdominal obesity, dyslipidemia, hypertension, elevated plasma glucose, pro-thrombotic state and proinflammatory state. Diabetes mellitus (DM), a metabolic disorder caused by impaired insulin secretion, peripheral insulin resistance or both, has become a major public health problem in India. Aims and Objectives: To evaluate the lipid profile in patients with Metabolic Syndrome at a tertiary health care centre Tamilnadu. Materials and methods: This is a crosssectional study carried out in the Department of Medicine, Shri Sathya Sai Medical College and Research Institute in Patients diagnosed with Metabolic syndrome were identified and randomly selected in all age groups. 50 metabolic syndrome patients (Cases) and age matched 50 normal patients (Controls) were enrolled into the study with written explained consent. All patients underwent lipid profile testing and fasting and post -prandial sugar level as per standard protocol. Statistical analysis was done with unpaired t-test and chi-square test using SPSS version 19 software. Results and Observations: our study contains that the majority of the patients were in the age group 61-70y -42%, 50-60y.29%, >70y 13% similarly controls were also 60-70y-38%, 50-60y -29%, >70y were 8% and hence both the cases and controls were comparable with age (p>0.05). The majority of the patients were male in both groups and male/ female ratios in the both cases and controls were comparable with each other (p>0.05). The mean FBS was significantly higher in cases than control i.e. 168.52±32.23 and 87.65±11.89 (<0.001**) The PPBS mg/dl was 290.23±41.24, 129.62±15.82 (<0.001**).The Total cholesterol mg/dl i.e.210. 13±21.78, 192.54±16.94 (<0.001**). LDL mg/dl 129.43±12.43, 101.45±12.87) (p<0.01**) ; Triglyceride mg/dl-11426 230.42±38.82,142.17±34.52(<0.01**) VLDLmg/dl51. 24±6.72, 33.23±3.59 (p<0.001**); was significantly higher in cases as compared to controls and HDL mg/dl was 33.17±7.23, 45.62±4.52 (p<0.01**) was significantly lesser than controls. Conclusion:our study concludes that the all patients with metabolic syndrome were having the deranged lipid profile level and that metabolic syndrome was more prevalent in the older age groups and in male patients.