Effectiveness of the d-ROMs oxidative stress test to predict long-term cardiovascular mortality

Hitomi, Yasuhiro; Masaki, Nobuyuki; Ishinoda, Yuki; Ido, Yasuo; Iwashita, Midori; Yumita, Yusuke; Kagami, Kazuki; Yasuda, Risako; Ikegami, Yasuyuki; Toya, Takumi; Namba, Takayuki; Nagatomo, Yuji; Takase, Bonpei; Adachi, Takeshi

doi:10.1016/j.ijcard.2022.03.001

Cited by 5 publications

(10 citation statements)

References 15 publications

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“…Oxidative stress is recognized as an important contributor to the pathogenesis of metabolic alterations including metabolic syndrome, type 2 diabetes and its complications [ 26 ], cancer [ 27 ], and CVD [ 12 ]. High total hydroperoxide plasma levels constitute an independent predictor of CVD events and mortality [ 28 , 29 ] and predict CAD in women [ 19 ]. Oxidative stress also plays a role in the decline of muscle mass and function (i.e., sarcopenia) observed during the aging process [ 10 ] and has been postulated to enhance bone resorption, possibly contributing to osteoporosis [ 30 ] and osteosarcopenic obesity [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Postmenopausal Women with or without Obesity

Leanza

Conte

Cannata

et al. 2023

Cells

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Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative stress states in postmenopausal women with or without obesity. Body composition was assessed via DXA, while lipid peroxidation and total hydroperoxides were measured in patient’s serum samples via thiobarbituric-acid-reactive substances (TBARS) and derivate-reactive oxygen metabolites (d-ROMs) assays, respectively. Accordingly, 31 postmenopausal women were enrolled: 12 with obesity and 19 of normal weight (mean (SD) age 71.0 (5.7) years). Doubled levels of serum markers of oxidative stress were observed in women with obesity in women with obesity compared to those of normal weight (H2O2: 32.35 (7.3) vs. 18.80 (3.4) mg H2O2/dL; malondialdehyde (MDA): 429.6 (138.1) vs. 155.9 (82.4) mM in women with or without obesity, respectively; p < 0.0001 for both). Correlation analysis showed that both markers of oxidative stress increased with an increasing body mass index (BMI), visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. In conclusion, obesity and visceral fat are associated with a greater increase in oxidative stress in postmenopausal women, possibly increasing cardiometabolic and cancer risks.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Postmenopausal Women with or without Obesity

Leanza

Conte

Cannata

et al. 2023

Cells

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“…ROS are constitutively present in cells and tissues in small but measurable concentrations [ 11 , 31 ]. They act as guidance cues during embryonic development [ 11 , 31 ] and as signaling molecules activating relevant biological and physiological pathways [ 10 , 32 ]. However, an increase in ROS production, such as during an altered metabolic state or as a consequence of chronic exposure to external/environmental factors, may have harmful effects [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The derivatives of reactive oxidative metabolites (d-ROMs) test analyzing the total amount of hydroperoxides in serum via the Fenton’s reaction [ 8 ] is used as an oxidative stress index, and the values correlate with the prognosis and mortality from cardiovascular events [ 10 , 11 ]. With the innovative plasma antioxidant capacity (PAT) test, we determine the total antioxidant capacity of the plasma through chromatography [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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D-ROMs and PAT Tests Reveal a High Level of Oxidative Stress in Patients with Severe Well-Controlled Asthma, and D-ROMs Are Positively Correlated with R20 Values That Indicate Approximate Central Airway Resistance

Kotsiou

Tourlakopoulos

Papathanasiou

et al. 2023

JPM

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Background: The derivatives-reactive oxygen metabolites (d-ROMs) and plasma antioxidant capacity (PAT) tests are oxidative indexes. Severe asthma has been related to oxidative stress. We aimed to investigate d-ROMs and PAT values in severely controlled asthmatics and the correlation of these values with lung function. Methods: Blood samples were collected from severely controlled asthmatics and centrifuged at 3000 rpm for 10 min. The supernatant was collected. The assays were performed within three hours of collection. The fraction of exhaled nitric oxide (FeNO), impulse oscillometry (IOS), and spirometry were determined. Symptom control was recorded using the asthma control test (ACT). Results: Approximately 40 patients with severe controlled asthma (75%: women), mean age of 62 ± 12 years, were recruited. Approximately 5% had obstructive spirometry. The IOS revealed airway abnormalities even though the spirometric results were within the normal range, with it being more sensitive than spirometry. The D-ROMs and PAT test values were higher than normal, indicating oxidative stress in severe asthmatics with controlled asthma. D-ROMs were positively correlated with R20 values, indicating central airway resistance. Conclusions: The IOS technique revealed an otherwise hidden airway obstruction with spirometry. The D-ROMs and PAT tests revealed a high level of oxidative stress in severe controlled asthmatics. D-ROMs correlate with R20, indicating central airway resistance.

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“…Another limitation of the study is that oxidative stress biomarkers have not been determined. Currently, the so-called derivatives-reactive oxygen metabolites (d-ROMs) [ 176 , 177 , 178 ] are an emerging biomarker of oxidative stress, and their measurement would have offered highly interesting information to relate it to the concentrations of trace elements and to the investigated cardiovascular risk factors. Finally, we did not analyze the genetic factors that may influence cardiovascular risk, which is still another limitation of our study.…”

Section: Discussionmentioning

confidence: 99%

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

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Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse associations between some of the most important essential trace elements (Zn, Cu, Se, and Mn) and cardiovascular disease, several recent studies have reported a direct association with cardiovascular risk factors due to the fact that these elements can act as both antioxidants and pro-oxidants, depending on several factors. This study aims to investigate the association between plasma and urine concentrations of trace elements and cardiovascular risk factors in a general population from the Mediterranean region, including 484 men and women aged 18–80 years and considering trace elements individually and as joint exposure. Zn, Cu, Se, and Mn were determined in plasma and urine using an inductively coupled plasma mass spectrometer (ICP-MS). Single and combined analysis of trace elements with plasma lipid, blood pressure, diabetes, and anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, and calculation of trace element risk scores (TERS) were used for the combined analyses. Models were adjusted for covariates. In single trace element models, we found statistically significant associations between plasma Se and increased total cholesterol and systolic blood pressure; plasma Cu and increased triglycerides and body mass index; and urine Zn and increased glucose. Moreover, in the joint exposure analysis using quantile g-computation and TERS, the combined plasma levels of Zn, Cu, Se (directly), and Mn (inversely) were strongly associated with hypercholesterolemia (OR: 2.03; 95%CI: 1.37–2.99; p < 0.001 per quartile increase in the g-computation approach). The analysis of urine mixtures revealed a significant relationship with both fasting glucose and diabetes (OR: 1.91; 95%CI: 1.01–3.04; p = 0.046). In conclusion, in this Mediterranean population, the combined effect of higher plasma trace element levels (primarily Se, Cu, and Zn) was directly associated with elevated plasma lipids, whereas the mixture effect in urine was primarily associated with plasma glucose. Both parameters are relevant cardiovascular risk factors, and increased trace element exposures should be considered with caution.

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Effectiveness of the d-ROMs oxidative stress test to predict long-term cardiovascular mortality

Cited by 5 publications

References 15 publications

Oxidative Stress in Postmenopausal Women with or without Obesity

Oxidative Stress in Postmenopausal Women with or without Obesity

D-ROMs and PAT Tests Reveal a High Level of Oxidative Stress in Patients with Severe Well-Controlled Asthma, and D-ROMs Are Positively Correlated with R20 Values That Indicate Approximate Central Airway Resistance

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

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