Effectiveness of the Association N-Palmitoylethanolamine and Transpolydatin in the Treatment of Primary Dysmenorrhea

Tartaglia, Edoardo; Armentano, Mario; Giugliano, Brunella; Sena, Teresa; Giuliano, P; Loffredo, Castrese; Mastrantonio, P

doi:10.1016/j.jpag.2014.12.011

Cited by 27 publications

(30 citation statements)

References 24 publications

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“…However, there are still more to explore behind these experiment data. Firstly, although plenty of clinical studies have been performed to evaluate the beneficial effect of polydatin on human [ 60 , 61 ], as far as we know, a few of them are focused on diabetes. Since several basic studies, including the present study, have investigated the therapeutic effect of polydatin on diabetes complication [ 62 , 63 ]; it is of great necessity to perform clinical investigation.…”

Section: Discussionmentioning

confidence: 99%

Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

Dong

et al. 2018

Oxidative Medicine and Cellular Longevity

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Diabetes exacerbates oxidative/nitrative stress during myocardial ischemia-reperfusion (MI/R) injury. Recent studies highlighted the cardioprotective actions of polydatin. However, its effect on diabetic MI/R injury and the underlying mechanisms remain unknown. This work was undertaken to evaluate the effect of polydatin on diabetic MI/R injury with a focus on Notch1/Hes1 signaling and myocardial oxidative/nitrative stress. Streptozotocin- (STZ-) induced diabetic rats were administered with polydatin (20 mg/kg/d) in the absence or presence of DAPT (a γ-secretase inhibitor) or LY294002 (a PI3K/Akt inhibitor) and then subjected to MI/R injury. Polydatin administration preserved cardiac function and reduced myocardial infarct size. Moreover, polydatin ameliorated myocardial oxidative/nitrative stress damage as evidenced by decreased myocardial superoxide generation, malondialdehyde, gp91phox expression, iNOS expression, NO metabolite level, and nitrotyrosine content and increased eNOS phosphorylation. However, these effects were blocked by DAPT administration. DAPT also inhibited the stimulatory effect of polydatin on the Notch1/Hes1-Pten/Akt signaling pathway in a diabetic myocardium. Additionally, LY294002 not only abolished polydatin's antiapoptotic effect but also reversed its inhibitory effect on myocardial oxidative/nitrative stress. Polydatin effectively reduced MI/R injury and improved left ventricular functional recovery under diabetic condition by ameliorating oxidative/nitrative stress damage. Importantly, Notch1/Hes1-mediated activation of Pten/Akt signaling played a crucial role in this process.

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Section: Discussionmentioning

confidence: 99%

Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

Dong

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…This study showed that the combination PEA-PLD represents a significant additional treatment to TENS, as it is able to down-regulate the hyperactivity of mast cells that are responsible for the proliferation and propagation of the vestibular pain fibers and of hyperalgesia and allodynia [101]. The combination of PEA and PLD appears to be a promising adjunctive therapy in the treatment of primary dysmenorrhoea in adolescents and young women [102]. In a more recent study, it was shown that the m-(PEA/PLD) compound was able to reduce the inflammatory pain that is induced by the injection of carrageenan in the hind paws of rats.…”

Section: Pea Synergy With Natural Molecules With Antioxidant Propmentioning

confidence: 99%

Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets

et al. 2019

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The use of a complete nutritional approach seems increasingly promising to combat chronic inflammation. The choice of healthy sources of carbohydrates, fats, and proteins, associated with regular physical activity and avoidance of smoking is essential to fight the war against chronic diseases. At the base of the analgesic, anti-inflammatory, or antioxidant action of the diets, there are numerous molecules, among which some of a lipidic nature very active in the inflammatory pathway. One class of molecules found in diets with anti-inflammatory actions are ALIAmides. Among all, one is particularly known for its ability to counteract the inflammatory cascade, the Palmitoylethanolamide (PEA). PEA is a molecular that is present in nature, in numerous foods, and is endogenously produced by our body, which acts as a balancer of inflammatory processes, also known as endocannabionoid-like. PEA is often used in the treatment of both acute and chronic inflammatory pathologies, either alone or in association with other molecules with properties, such as antioxidants or analgesics. This review aims to illustrate an overview of the different diets that are involved in the process of opposition to the inflammatory cascade, focusing on capacity of PEA and new formulations in synergy with other molecules.

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“…These are highest during the first two days of menstruation, which coincides with the period of greatest pain. MC degranulation may play a role in peripheral nerve sensitization and pelvic pain [ 74 ], which, if recurrent, may cause central sensitization and increase susceptibility to other chronic pain conditions. As PEA down-regulates COX-2 and prevents the recruitment and activation of MCs, it would be expected to mitigate the hyperinflammatory state present in dysmenorrhea.…”

Section: Pea and Painmentioning

confidence: 99%

“…As PEA down-regulates COX-2 and prevents the recruitment and activation of MCs, it would be expected to mitigate the hyperinflammatory state present in dysmenorrhea. In one trial, the combined administration of PEA-transpolydatin (400 mg + 40 mg) for 10 days to young women with primary dysmenorrhea significantly reduced pelvic pain compared to placebo [ 74 ].…”

Section: Pea and Painmentioning

confidence: 99%

Palmitoylethanolamide: A Natural Compound for Health Management

Clayton¹,

Hill

Bogoda

et al. 2021

IJMS

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All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management.

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Effectiveness of the Association N-Palmitoylethanolamine and Transpolydatin in the Treatment of Primary Dysmenorrhea

Cited by 27 publications

References 24 publications

Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets

Palmitoylethanolamide: A Natural Compound for Health Management

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