Effectiveness of testosterone therapy for masculinizing voice in transgender patients: A meta-analytic review

Ziegler, Aaron; Henke, Travis; Wiedrick, Jack; Helou, Leah B.

doi:10.1080/15532739.2017.1411857

Cited by 40 publications

(39 citation statements)

References 42 publications

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“…[8] Furthermore, most of the studies involving trans-male vocal characteristics have been conducted with relatively small sample sizes, lack information about pre-treatment vocal status and have often focused on the outcomes of testosterone treatment. [8,9] Although androgen therapy is generally considered adequate to alter the voice in the desired direction for transmales, recent studies have reported significant diversity in response to treatment. [9] A recent meta-analysis including the results of individuals who had been receiving treatment for at least 1 year, investigated the efficacy of testosterone therapy in masculinizing the voice in transgender individuals.…”

Section: Discussionmentioning

confidence: 99%

“…[8,9] Although androgen therapy is generally considered adequate to alter the voice in the desired direction for transmales, recent studies have reported significant diversity in response to treatment. [9] A recent meta-analysis including the results of individuals who had been receiving treatment for at least 1 year, investigated the efficacy of testosterone therapy in masculinizing the voice in transgender individuals. [9] A failure ratio of 21% to achieve the cisgender male normative frequency range (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is no definitive a bsolute d istinction b etween m asculine a nd feminine F0, in a recent meta-analysis the following values were used to evaluate the response to testosterone in trans males: cisgender male normative frequencies are at or below 131 Hz, cisgender female normative frequencies are 185 Hz or above, and the gender ambiguous frequency range is 185 Hz or less. [9,13,14] Statistical analysis was performed using the SPSS v22 (IBM Corp., Armonk, NY, USA) application. Descriptive statistics were generated for all the variables.…”

Section: Acoustic Analysismentioning

confidence: 99%

“…[6][7][8] In a recent meta-analysis, an overall rate of 16% was reported for incomplete satisfaction with vocal quality in spite of hormonal treatment, and in particular subgroups, this dissatisfaction reached a rate approaching 30%. [9] Factors thought to affect treatment outcome include differing sizes of the laryngeal framework and androgen insensitivity, as well as marked variations in the testosterone regime followed. [9] The treatment regimens in use include various administrations and dosages and are not standardised.…”

Section: Introductionmentioning

confidence: 99%

“…[9] Factors thought to affect treatment outcome include differing sizes of the laryngeal framework and androgen insensitivity, as well as marked variations in the testosterone regime followed. [9] The treatment regimens in use include various administrations and dosages and are not standardised. [10] In any case, it is still unclear to what extent treatment should be maintained and whether or not it should be administered to every individual in an identical manner.…”

Section: Introductionmentioning

confidence: 99%

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Association between Subjective and Objective Voice Masculinity in Hormone Naïve Trans Male Individuals

Şirin¹,

Polat²

2019

ENT Updates

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Objective: The aim of this study is to investigate the association between subjective and objective masculine vocal quality in hormone-naïve trans-male individuals. Methods: Twenty-seven hormone-naïve trans-male individuals were recruited for the study. All the study participants had applied to undergo the gender transition process and been referred to the Voice Clinic. The Self-Perception of Voice Masculinity (SPVM) scale and the mean fundamental frequency (F0) were used to assess any association between subjective and objective vocal masculinity. Results: The mean age of study participants was 25.3 years. The median F0 lay within the normal limits for cisgender females. However, in 12 out of 27 cases, F0 lay within the gender-ambiguous frequency range. SPVM scores were higher in this ambiguous group, a result with a strong tendency toward statistical significance (p=0.053). A moderate negative correlation between SPVM and F0 scores was observed (r=-0.484, p=0.027). The smoking frequency was high, with 77.8% of individuals in the group as a whole being smokers. Not only were F0 values of smokers lower than those of non-smokers, but their SPVM scores were also higher. Conclusion: The findings from this study indicate that diversity in objective and subjective voice parameters exists even within the hormone naïve period. There appear to be several factors which influence F0 to a significant extent. Accordingly, a more comprehensive approach is called for when assessing transgender voice at all stages of the gender-affirming medical treatment process. The high frequency of smoking amongst the trans-male population should also be noted as it constitutes a serious health hazard.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Acoustic Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Subjective and Objective Voice Masculinity in Hormone Naïve Trans Male Individuals

Şirin¹,

Polat²

2019

ENT Updates

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Gauging Stakeholder Perspectives on Artificial Intelligence in Gender‐Affirming Voice Care

et al. 2022

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Background As the main objective outcome measure used in gender‐affirming voice care (GAVC), fundamental frequency (f0) often fails to accurately reflect patient perceptions of their voice. Our team developed an artificial intelligence (AI) program that provides an alternative objective outcome measure that has the potential to more accurately align with patient perceptions. Objective To gauge stakeholder receptivity to the use of AI in GAVC before employing a novel outcome measure in transgender and nonbinary communities. Methods This prospective qualitative study used online focus groups composed of speech‐language pathologists (SLPs), transgender men (TGM), transgender women (TGW), and nonbinary (NB) individuals. Participant age, race, gender, and geographic location were recorded. Each cohort participated in a series of two focus group sessions. The first session focused on participant experiences in GAVC, whereas the second ascertained participant perspectives on the use of AI in GAVC. Transcripts of each discussion were coded using Nvivo to perform inductive thematic analysis. Results Seven SLPs, seven TGW, three TGM, and two NB individuals (mean [range] age, 35.5 [26–48] years) participated. Transgender and nonbinary participants were generally amenable to the technology, whereas SLPs were more hesitant about its use. Positive findings included appreciation for AI as an objective outcome measure and enthusiasm for its potential to longitudinally track progress. Hesitations concerned the actionability of using the AI and unease about the black box nature of the AI's analysis. Conclusion Transgender and NB individuals were receptive to the use of AI technology in GAVC, whereas SLPs were more apprehensive about using AI. Level of Evidence NA Laryngoscope, 133:1698–1705, 2023

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Voice Pitch Shaping and Genderization: New Needs of Cosmetic Phonoplastic Surgery

Li,

Zhang,

Chen

et al. 2024

Aesth Plast Surg

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Effectiveness of testosterone therapy for masculinizing voice in transgender patients: A meta-analytic review

Cited by 40 publications

References 42 publications

Association between Subjective and Objective Voice Masculinity in Hormone Naïve Trans Male Individuals

Association between Subjective and Objective Voice Masculinity in Hormone Naïve Trans Male Individuals

Gauging Stakeholder Perspectives on Artificial Intelligence in Gender‐Affirming Voice Care

Voice Pitch Shaping and Genderization: New Needs of Cosmetic Phonoplastic Surgery

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