Effectiveness of surveillance cultures for high priority multidrug-resistant bacteria in hematopoietic stem cell transplant units

Mendes, Elisa Donalísio Teixeira; Salomão, Matias Chiarastelli; Tomichi, Lísia Moura; Oliveira, Maura Salaroli de; Graca, M; Rossi, Flávia; Sapadao, Fernanda; Guimarães, Thaís; Rocha, Vanderson; Costa, Sílvia Figueiredo

doi:10.1590/s1678-9946202163077

Cited by 3 publications

(3 citation statements)

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“…Studies by Mendes et al and Sadowska-Klasa et al have shown an association between pre-colonization of the gut by P. aeruginosa resistant to carbapenems (CRPA) and bloodstream infection caused by the same strains in patients undergoing HSCT (hematopoietic stem cell transplant). The incidence of MDR bacteremia is higher in patients with MDR colonization than in non-colonized patients [21,22]. P. aeruginosa is not a common member of the gut microbiota in healthy people.…”

Section: P Aeruginosa Colonizationmentioning

confidence: 98%

“…Patients colonized/infected by the most dangerous resistant strains are isolated in single rooms depending on the availability of individual rooms in the facility [89]. Moreover, knowledge of the colonizing microorganism can be helpful in guiding the empirical antibiotic therapy [21]. Unfortunately, although surveillance stool screening (SSS) can be useful to identify hematological patients (HSCT recipients) with intestinal colonization by MDR Enterobacterales, in the case of P. aeruginosa, SSS is not highly effective because the intestinal tract is not the only possible source of infection in this group of patients [83].…”

Section: Prevention Of P Aeruginosa Infection In Cancer Patientsmentioning

confidence: 99%

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Pseudomonas aeruginosa Infections in Cancer Patients

et al. 2022

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Pseudomonas aeruginosa (P. aeruginosa) is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respiratory, urinary tract and skin infections. The wide intrinsic and the increasing acquired resistance of P. aeruginosa to antibiotics make the treatment of infections caused by this microorganism a growing challenge. Although novel antibiotics expand the arsenal of antipseudomonal drugs, they do not show activity against all strains, e.g., MBL (metalo-β-lactamase) producers. Moreover, resistance to novel antibiotics has already emerged. Consequently, preventive methods such as limiting the transmission of resistant strains, active surveillance screening for MDR (multidrug-resistant) strains colonization, microbiological diagnostics, antimicrobial stewardship and antibiotic prophylaxis are of particular importance in cancer patients. Unfortunately, surveillance screening in the case of P. aeruginosa is not highly effective, and a fluoroquinolone prophylaxis in the era of increasing resistance to antibiotics is controversial.

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Section: P Aeruginosa Colonizationmentioning

confidence: 98%

Section: Prevention Of P Aeruginosa Infection In Cancer Patientsmentioning

confidence: 99%

Pseudomonas aeruginosa Infections in Cancer Patients

et al. 2022

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“…Nevertheless, bad prescription habits are also very present like in all other Latin American countries, and many hospitals suffer from multi-resistant bacteria which differ between two hospitals even closely within the same city. 75 A few of them established special units driven by microbiologists who monitor the situation and try to identify multi-resistance.…”

Section: Resultsmentioning

confidence: 99%