Effectiveness of Sildenafil in Treating Erectile Dysfunction in PTSD Patients

Abstract

The results of this study suggest that sildenafil citrate treatment for ED in PTSD patients was accompanied with improvement of ED symptoms and was found to be significantly better than placebo. Nevertheless, this effect should be considered marginal since patients still meet the criteria of ED after treatment. Larger, parallel group studies are warranted.

Sexual Problems Predict PTSD and Depression Symptom Change Among Male OEF/OIF Veterans Completing Exposure Therapy

“…The finding that overall problems in sexual functioning did not improve during BA-TE is consistent with the persistence or exacerbation of sexual problems seen among patients with PTSD treated with SSRIs or sildenafil citrate (Kotler et al, 2000; Orr et al, 2006; Safarinejad et al, 2009). Although participants with significant sexual problems at baseline did report greater improvements (particularly in terms of sexual arousal) as compared to those without sexual problems at baseline, the small overall effect on sexual problems suggests that these issues may require additional attention among veterans presenting for treatment of PTSD and depression symptoms.…”

“…Despite this, far less research has focused on the treatment of these co-occurring conditions (Kotler et al, 2000; Orr et al, 2006; Safarinejad, Kolahi, & Ghaedi, 2009). Selective serotonin reuptake inhibitors (SSRIs) are a common class of medications prescribed to treat symptoms of both depression and PTSD (Kupfer, Frank, & Phillips, 2012; Steckler & Risbrough, 2012).…”

“…In contrast, only two studies have examined the impact of ED medication use among patients with PTSD and sexual dysfunction. Orr and colleagues (2006) investigated 21 veterans with PTSD and ED symptoms in a 4-week double-blind crossover design for sildenafil citrate and placebo. Results demonstrated significant improvements in ED symptoms, but not ED diagnosis (Orr et al, 2006).…”

“…Orr and colleagues (2006) investigated 21 veterans with PTSD and ED symptoms in a 4-week double-blind crossover design for sildenafil citrate and placebo. Results demonstrated significant improvements in ED symptoms, but not ED diagnosis (Orr et al, 2006). In the second study, Safarinejad and colleagues (2009) investigated 266 veterans with PTSD who were randomized into either the sildenafil citrate or placebo groups for 16 doses/attempts.…”

UV-vis spectroscopic study of lipid peroxidation and antioxidant contents of kidney of Albino mice co-administrated with sildenafil citrate and alcohol

“…The medication amplifies the effects of sexual stimulation by regarding the degradation of this enzyme. Sildenafil has been found effective in several subpopulations of men with ED, including sufferers from diabetes, hypertension, spinal cord injuries [7], multiple sclerosis [11], depression [10,36], PTSD [25], men after resection of the prostate or radical prostatectomy [22], after renal transplant [30], men on dialysis [5] and men aged 65 years and older [3].…”