Effectiveness of seasonal 2008–2009, 2009–2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case–control study

Puig-Barberà, Joan; Arnedo-Pena, Alberto; Pardo-Serrano, Francisco; Tirado-Balaguer, María Dolores; Perez‐Vilar, Silvia; Silvestre-Silvestre, Ester; Calvo-Mas, Consuelo; Safont-Adsuara, Lourdes; Ruiz‐García, Montserrat

doi:10.1016/j.vaccine.2010.09.042

Cited by 84 publications

(78 citation statements)

References 37 publications

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“…This is supported by findings from Canada, which found mass vaccination to be cost effective [25,26]. Twenty-five patients were vaccinated with Pandemrix ® prior to hospital admission of which 11 patients had confirmed Influenza A(H1N1)pdm09.…”

Section: Discussionsupporting

confidence: 52%

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Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway

Mohn¹,

Lrum²,

Skrede³

et al. 2013

J Vaccines Vaccin

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Background: Norway had a preorder of pandemic vaccine, when the pandemic influenza A (H1N1)pdm09 in 2009 was declared. Mass vaccination occurred 1-3 weeks prior to the peak of the pandemic. Emergency plans were in place, but the predicted severe numbers of hospitalizations did not occur. Objective:To study the epidemiology and clinical presentation of adult patients hospitalized with Influenza A(H1N1)pdm09, and to evaluate the impact of vaccination on the course of the pandemic at a tertiary hospital. Methods:The low dose oil-in-water adjuvanted vaccine was used to vaccinate healthcare workers (HCWs) and at risk patients groups, and vaccination rates were recorded for the community and the hospital. Demographic and clinical information was obtained for 129 patients (>15 years), hospitalized with influenza A (H1N1)pdm09 between August 2009-January 2010. A confirmed case of influenza A (H1N1)pdm09 was defined as meeting a clinical case definition and/or laboratory confirmed disease (rt-PCR or serology). Hospital stay of more than 2 days was defined as a sign of severe illness.Results: 1/3 of at risk patients in the community and >90% of frontline HCWs at the hospital were vaccinated. The median length of hospital stay of infected patients was significantly reduced 7 days after the onset of mass vaccination (p=0.029). There was a predominance of female and moderately obese (BMI 25-30) patients. Infiltration on chest X-ray upon admission was significantly associated with a hospital stay of >2 days (p=0.001). Conclusion:Mass vaccination of frontline HCWs at the hospital and at risk patients in the community contributed to the observed significant reduction in hospital stay of patients infected with influenza. Almost no absenteeism enabled staff confidence and the ability for quick and safe patient turnover. This study highlights the importance of early influenza vaccination, to protect the high-risk patients and the integrity of the healthcare system.

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Section: Discussionsupporting

confidence: 52%

“…These findings suggest that the pandemic vaccine provided protection from influenza illness, avoiding hospitalization in patients at highest risk of severe disease who would have required longer hospital stay ( Figure 2) [5,[25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway

Mohn¹,

Lrum²,

Skrede³

et al. 2013

J Vaccines Vaccin

View full text Add to dashboard Cite

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“…infection with influenza A(H1N1)pdm09 is uncertain, and a range of estimates have been made, which range from indicating protection, [10][11][12][13] to no effect, [14][15][16][17][18][19][20][21][22][23] to increased susceptibility. [24][25][26] A recent meta-analysis found that prior receipt of seasonal influenza vaccination may have been associated with moderate protection against influenza A(H1N1)pdm09.…”

Section: Resultsmentioning

confidence: 99%

Pandemic influenza A(H1N1)pdm09: risk of infection in primary healthcare workers

Hudson¹,

Toop²,

Mangin³

et al. 2013

Br J Gen Pract

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“…Controls were considered vaccinated if they had received a dose at least 14 d before the onset of symptoms of the matched case. As there is evidence that the immune response induced by the adjuvanted pandemic vaccine is more rapid than that of seasonal influenza vaccines, [40][41][42] patients were considered vaccinated if they had received the is unlikely that the protection observed in cases compared with controls could be attributed to factors studied other than PPV23 and influenza vaccination.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons

Domı́nguez

Castilla

Godoy

et al. 2013

Human Vaccines & Immunotherapeutics

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Results: 1187 cases and 2328 controls were included. The adjusted estimate of effectiveness of pneumococcal vaccination in preventing influenza hospitalization was 41% (95% cI 8-62) in all patients and 43% (95% cI 2-78) in patients aged ≥ 65 y. The adjusted effectiveness of dual ppV23 and influenza vaccination was 81% (95% cI 65-90) in all patients and 76% (95% cI 46-90) in patients aged ≥ 65 y. The adjusted effectiveness of influenza vaccination alone was 58% (95% cI 38-72).Methods: We conducted a multicenter case-control study in 36 spanish hospitals. We selected patients aged ≥ 18 y hospitalized with confirmed influenza and two hospitalized controls per case, matched according to age, date of hospitalization and province of residence. Multivariate analysis was performed using conditional logistic regression. subjects were considered vaccinated if they had received the pneumococcal or seasonal influenza vaccine ≥ 14 d (or ≥ 7 d for pandemic influenza vaccine) before the onset of symptoms (cases) or the onset of symptoms in matched cases (controls).Conclusions: In elderly people and adults with chronic illness, pneumococcal vaccination may reduce hospitalizations during the influenza season. In people vaccinated with both the influenza and pneumococcal vaccines, the benefit in hospitalizations avoided was greater than in those vaccinated only against influenza.

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Effectiveness of seasonal 2008–2009, 2009–2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case–control study

Cited by 84 publications

References 37 publications

Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway

Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway

Pandemic influenza A(H1N1)pdm09: risk of infection in primary healthcare workers

Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons

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