“…2,8 The severity of frostbite is related to vascular insufficiency, altitude, duration of exposure, tissue wetness, previous exposure to cold injury, age and other factors. 9 Thromboxanes and prostaglandins also play an important role in frostbite injuries. 5 Frostbite is classified in four degrees, with superficial frostbite comprising the 1st and 2nd degrees and deep frostbite the 3rd and 4th degrees.…”