Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of <i>Helicobacter pylori</i> in Turkey

Alkım, Hüseyin; Iscan, M; Öz, Fahrettin

doi:10.3402/ljm.v6i0.8412

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…İstanbul'da yaptığı bir araştırmada klaritromisin ve amoksisiline eşlik eden rabeprazol ile bizmut kombinasyonunun diğer PPİ + bizmut kombinasyonlarına göre anlamlı olarak daha başarılı olduğunu belirtmişlerdir. 19…”

Section: Discussionunclassified

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Çekın¹

2012

Dicle Med J

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Objective: Success rates of amoxicillin, clarithromycin, and proton-pump inhibitor therapy in the Helicobacter pylori (Hp) eradication have been decreasing. The aim of this study was to investigate the impact of bismuth subcitrate addition to triple therapy. Materials and methods: 148 patients diagnosed Hp infection with both histology and Hp stool antigen (HpSA) tests were examined retrospectively. The patients were divided into 3 groups according to the eradication therapy. The first group received triple therapy with claritromycine 2x 500 mg, amoxicilline 2x1 g and PPI 2x1 for 14 days (n=40). The second group had bismuth subcitrate 4x120 mg with triple therapy for 14 days (n=73). The third group received 14 days pretreatment with bismuth subcitrate 4x1 together with PPI 2x1 then had triple therapy for 14 days (n=35). (14)C urea breath and HpSA tests were used to detect posttreatment H.pylori status. Results: There were no statistical difference between the groups in terms of gender and age (p > 0.05). In group one 12 patients, in group two 20 patients and in group three 10 patients were identified as Hp positive after treatment. Eradication rates were 70% for group one, 72.6% for group two and 71.4% for group three respectively. There was no statistical difference between the groups in terms of eradication rates of treatment (p > 0.05). Conclusions: The addition of bismuth to conventional triple therapy did not affect treatment success rates.

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Section: Discussionunclassified

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Çekın¹

2012

Dicle Med J

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“…Ulusal bir metaanalizde Türkiye'de Hp eradikasyon oranının PPI-bazlı 3'lü tedavi ile 1997'de %84 iken, 2004'te %55.3'e düştüğü belirtilmiştir. [22] Son dönemde ülkemizde yapılan pek çok çalışmada gösterildiği üzere bu durumdan klaritromisin direnci (primer ve/veya sekonder) sorumlu tutulmaktadır. Bununla birlikte yeni antibiyotiklere karşı direnç gelişmesi kaçınılmaz görünmektedir.…”

Section: Bulgularunclassified

Mayalanmış Ev Yoğurdunun Helikobakter Pilori Eradikasyonuna Etkisi

Yoldemir¹

2019

bogazicitip

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Objectives: Helicobacter pylori (Hp) infection is common worldwide and may be involved in the pathogenesis of gastritis, peptic ulcer, and gastric malignancy. Treatment has been effective; however, due to the increasing antibiotic resistance of Hp, there is renewed interest in research. Studies have indicated that the addition of probiotic yogurt to treatment may increase the rate of Hp eradication. This study was an investigation of the effect of the addition yogurt to the standard, first-line treatment on Hp eradication and patient compliance. Methods: A total of 147 patients were included in the study. Patients who were diagnosed with Hp infection in an endoscopic examination using the histological method were given eradication treatment. The consumption of yogurt in the home was questioned. Patients who used at least 80% of the prescribed drugs were considered to have complied with the treatment. A stool antigen test was performed 4 weeks after the end of treatment to assess Hp eradication. Results: Intention-to-treat analysis revealed that eradication was achieved in 50 (57.4%) of the 80 patients who received only first-line treatment and 21 (39%) of the 60 patients receiving yogurt + first-line treatment. Per-protocol analysis indicated that Hp eradication was achieved in 50 patients (76.9%) of the 65 patients who received yogurt + first-line treatment. Yogurt + first-line treatment had a better eradication rate (p=0.009; p=0.028). Conclusion: The Hp eradication rate increased with the addition of yogurt added to the standard treatment. Factors such as age, gender, and education level did not affect eradication.

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“…However, out of 12 studies conducted in Turkey to evaluate the effects of 7-, 10-and 14-d standard triple therapies on H. pylori eradication, only one of the 14-d regimens could achieve an acceptable eradication rate [28][29][30][31][32][33][34][35][36][37][38][39] (Table 3).…”

Section: Standard Triple Therapymentioning

confidence: 99%

“…Besides, only one of the 9 studies conducted in Turkey had 90.1% PP eradication rate (Table 3) [30,[34][35][36][53][54][55][56][57] .…”

Section: Therapymentioning

confidence: 99%

Helicobacter pylorieradication in West Asia: A review

Fakheri

Bari

Aarabi

et al. 2014

WJG

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The efficacy of first-and second-line Helicobacter pylori (H. pylori ) eradication regimens varies considerably in West Asian countries, mainly due to the variable prevalence of resistant organisms. However, no review article has yet evaluated and compared the efficacy of different regimens among different countries of this region. Therefore, we conducted a review to select the best options and provide recommendations for H. pylori treatment in this geographic region. A search through PubMed was carried out to obtain relevant randomized clinical trials published in English language up to June 2013. According to the results, among different therapeutic regimens used as the first-line protocols, 10-d Bismuth-Furazolidone/Metronidazole quadruple therapy, 14-d Clarithromycin-containing hybrid therapy and 14-d quadruple therapy including a proton pump inhibitor + Bismuth + Tetracycline (500 mg QID) + Metronidazole (500 mg TDS) seemed to be appropriate options. Among second-line therapeutic regimens, Bismuthbased quadruple therapies containing Tetracycline and Furazolidone/Metronidazole, triple therapy containing Amoxicillin and Gatifloxacin and Quadruple therapy including Bismuth + Azithromycin and Ofloxacin seemed to be effective options. Third-line therapies were not evaluated in West Asia; most guidelines, however, recommend choosing optimal eradication regimen according to the pattern of antibiotic susceptibility of H. pylori . Although we limited our investigation to H. pylori eradication regimens in West Asia, the clinical significance of the results goes beyond the countries situated in this geographic region. In fact, the results are transferrable to any region as long as the patterns of resistance are the same. Core tip: The efficacy of first-and second-line Helicobacter pylori (H. pylori ) eradication regimens varies considerably in West Asian countries, mainly due to the variable prevalence of resistant organisms. The present study evaluates and compares the efficacy of different regimens among different countries of this region. Although we limited our investigation to H. pylori eradication regimens in West Asia, the clinical significance of the results goes beyond the countries situated in this geographic region. In fact, the results are transferrable to any region as long as the patterns of resistance are the same.

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Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey

Cited by 9 publications

References 31 publications

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Mayalanmış Ev Yoğurdunun Helikobakter Pilori Eradikasyonuna Etkisi

Helicobacter pylorieradication in West Asia: A review

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