Effectiveness of radiotherapy for elderly patients with anaplastic gliomas

Mukherjee, Debraj; Sarmiento, J. Manuel; Nosova, Kristin; Boakye, Maxwell; Lad, Shivanand P.; Black, Keith L.; Nuño, Miriam A; Patil, Chirag G.

doi:10.1016/j.jocn.2013.09.004

Cited by 10 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The summary results indicated a significant improvement in the survival outcomes in elderly patients who received GTR. Although most included studies reported a significant improvement in OS, four reports showed no significant therapeutic advantage of GTR vs. STR (27,36,38,40). This might be due to the small numbers of included patients, and wide 95%CIs were obtained.…”

Section: Discussionmentioning

confidence: 92%

“…A total of 76 studies were retrieved for full-text evaluation, and 57 were further excluded due to the following reasons: no appropriate control (n = 29), inclusion of younger patients (n = 20), and no sufficient data (n = 8). Therefore, 19 studies met our inclusion criteria and were selected for final meta-analysis (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). There were no additional eligible studies from the manual search of the reference lists of these studies.…”

Section: Literature Searchmentioning

confidence: 99%

See 1 more Smart Citation

Gross Total vs. Subtotal Resection on Survival Outcomes in Elderly Patients With High-Grade Glioma: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

Background: The optimal strategy for the management of high-grade glioma in the elderly (≥60.0 years) remains controversial, especially regarding the effects of surgical extent on survival outcomes. The purpose of this study was to compare gross total resection (GTR) with subtotal resection (STR) for treatment effects in elderly patients with high-grade glioma.Methods: Three electronic databases were systematically searched, including PubMed, EmBase, and the Cochrane library, from inception to August 2018. Hazard ratios (HRs) or odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to express summary effect estimates using the random-effects model. Nineteen retrospective observational studies involving a total of 10,815 elderly patients with high-grade glioma were included in this meta-analysis.Results: The summary results indicated that GTR was associated with a significant improvement in overall survival (OS) compared with STR (HR = 0.70, 95% CI = 0.64-0.77). In addition, elderly patients administered GTR showed lower risk of 3-month mortality (OR = 0.47, 95% CI = 0.24-0.93), 6-month mortality (OR = 0.38, 95% CI = 0.26-0.56), 9-month mortality (OR = 0.35, 95% CI = 0.25-0.49), and 1-year mortality (OR = 0.40, 95% CI = 0.29-0.56). Pooled OS data differed when stratified by publication year, country, sample size, disease status, and study quality.Conclusion: GTR seems to be more effective than STR in achieving longer survival in elderly patients with high-grade glioma.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Literature Searchmentioning

confidence: 99%

Gross Total vs. Subtotal Resection on Survival Outcomes in Elderly Patients With High-Grade Glioma: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Pavlicevic et al (2003) concluded that the outcome after the operative treatment of malignant astrocytoma depends significantly on the patient's age and the extent of the tumor [11]. In the study on 390 patients with anaplastic glioma and anaplastic astrocytoma, Mukherjee et al (2014) found that the median survival rate in patients with gross total resection and radiotherapy was 11 months [12]. According to Graus et al (2013), in GBM patients after surgical resection of the tumor, initiation of radiotherapy ≤42 days was associated with better progression-free survival [13].…”

Section: Discussionmentioning

confidence: 99%

Three-Year Survival Rate in All Kinds of Glioma Tumors in One Institution, Iran, 2001-2010

Rezaee

Mansour

2020

Iran J Neurosurg

View full text Add to dashboard Cite

Background and Aim: The survival rate of brain tumors has not yet been reported in Iran. The purpose of this study, given the lack of such information, was to evaluate the 3-year survival rate in patients with all kinds of glioma tumors. Methods and Materials/Patients: This study was descriptive and retrospective, including 222 patients who had been diagnosed clinically with one type of glioma tumor and admitted to Al-Zahra hospital, Isfahan, Iran during 2001-2010. All patients (for minors, their parents) were contacted by phone. They were asked about the 3-year survival rate following their tumor resection surgery. Data such as patient’s age on admission, gender, histological diagnosis of tumor, and treatment regimen (surgical/non-surgical, radiation, and/or chemotherapy) were collected from medical records. The 3-year survival rate and frequency of each tumor based on age and gender were measured. Results: The 3-year survival rates for Glioblastoma Multiform (GBM) and anaplastic astrocytoma were 8.7% and 0%, respectively following surgery and chemo-radiation. These tumors were categorized as high-grade glioma with poor prognosis. The 3-year survival rate for diffuse astrocytoma, low-grade oligodendroglioma, low-grade ependymoma, and pilocytic astrocytoma following surgery and radiation were 100%, 95.2%, 100%, and 100%, respectively. These tumors were categorized as low-grade glioma, which has a good prognosis. Conclusion: In this study, the 3-year survival rate in patients with low-grade glioma following surgery and radiation was almost 100%. In contrast, the 3-year survival rate in patients with highgrade glioma following surgery and chemo-radiation was almost 0%.

show abstract

“…Prognostic factors for AA included age, RCT, private insurance, higher income, tumor site, marital status, EOR, histology, and treatment with RT. [38][39][40][41][42][43][44] Smoll et al specifically looked at 3,202 patients with AA between 1973 and 2006 in the SEER database, showing worsened mortality compared with matched controls. 43 A 5-and 10year overall survival (OS) of 23.6% and 15.1% was identified, respectively.…”

Section: High-grade Gliomamentioning

confidence: 99%

Utility of Administrative Databases and Big Data on Understanding Glioma Treatment—A Systematic Review

Owens

Nguyen

Karsy

2022

Indian Journal of Neurosurgery

View full text Add to dashboard Cite

Background Gliomas are a heterogeneous group of tumors where large multicenter clinical and genetic studies have become increasingly popular in their understanding. We reviewed and analyzed the findings from large databases in gliomas, seeking to understand clinically relevant information. Methods A systematic review was performed for gliomas studied using large administrative databases up to January 2020 (e.g., National Inpatient Sample [NIS], National Surgical Quality Improvement Program [NSQIP], and Surveillance, Epidemiology, and End Results Program [SEER], National Cancer Database [NCDB], and others). Results Out of 390 screened studies, 122 were analyzed. Studies included a wide range of gliomas including low- and high-grade gliomas. The SEER database (n = 83) was the most used database followed by NCDB (n = 28). The most common pathologies included glioblastoma multiforme (GBM) (n = 67), with the next category including mixes of grades II to IV glioma (n = 31). Common study themes involved evaluation of descriptive epidemiological trends, prognostic factors, comparison of different pathologies, and evaluation of outcome trends over time. Persistent health care disparities in patient outcomes were frequently seen depending on race, marital status, insurance status, hospital volume, and location, which did not change over time. Most studies showed improvement in survival because of advances in surgical and adjuvant treatments. Conclusions This study helps summarize the use of clinical administrative databases in gliomas research, informing on socioeconomic issues, surgical outcomes, and adjuvant treatments over time on a national level. Large databases allow for some study questions that would not be possible with single institution data; however, limitations remain in data curation, analysis, and reporting methods.

show abstract

Effectiveness of radiotherapy for elderly patients with anaplastic gliomas

Cited by 10 publications

References 18 publications

Gross Total vs. Subtotal Resection on Survival Outcomes in Elderly Patients With High-Grade Glioma: A Systematic Review and Meta-Analysis

Gross Total vs. Subtotal Resection on Survival Outcomes in Elderly Patients With High-Grade Glioma: A Systematic Review and Meta-Analysis

Three-Year Survival Rate in All Kinds of Glioma Tumors in One Institution, Iran, 2001-2010

Utility of Administrative Databases and Big Data on Understanding Glioma Treatment—A Systematic Review

Contact Info

Product

Resources

About