Effectiveness of radiation therapy in the management of sarcoma of the soft somatic tissues

McNeer, Gordon; Cantin, Jacques; Chu, Florence C. H.; Nickson, James J.

doi:10.1002/1097-0142(196808)22:2<391::aid-cncr2820220217>3.0.co;2-q

Cited by 152 publications

(27 citation statements)

References 2 publications

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“…Radiation therapy to the liver has been used to palliate liver metastases [21] , but soft tissue sarcoma is relatively radioresistant and the dosage required to treat sarcoma is higher than the tolerable dose [22] . Chemotherapy plays a role in the treatment of soft tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Hepatic angiosarcoma manifested as recurrent hemoperitoneum

Lee

Song²,

Gi³

et al. 2008

WJG

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Section: Discussionmentioning

confidence: 99%

Hepatic angiosarcoma manifested as recurrent hemoperitoneum

Lee

Song²,

Gi³

et al. 2008

WJG

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“…17 The introduction to this article clearly described the bias against the use of radiotherapy that was operative at that time: ''Sarcomas of the soft tissues have generally been considered as radioresistant tumors for which surgical excision has been the preferred method of treatment in the curable phase.'' 17 Although several experts cited in the introduction were at best modestly enthusiastic about the use of radiotherapy in soft tissue sarcoma, the authors comment that ''In the last 20 years there has been no significant improvement in the overall cure rate of many types of cancer, including soft tissue sarcomas. .…”

Section: Therapy For Sarcomamentioning

confidence: 99%

“…We advocate dose levels of 3000-4000 rads in 3-4 weeks, surgery to follow in approximately 2-3 weeks.'' 17 The authors also mention that the 5-year and 10-year survival rates of many patients treated with radiotherapy and surgery were at least equal to and sometimes better than those achieved using surgery alone, and that patients who received preoperative radiotherapy in which 100% tumor necrosis was achieved enjoyed the highest overall survival rates, further supporting the need to prospectively evaluate the combination of radiotherapy with surgery.…”

mentioning

confidence: 96%

The seminal role ofCancerin our understanding of sarcoma

Pollock

2008

Cancer

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The journal Cancer has played a critical role in advancing our understanding of sarcoma, a remarkable cluster of malignancies that arise from tissues of KEYWORDS: sarcoma, prognostic factors, staging systems, therapy for sarcoma. Because of the relative rarity of malignant disease of the connective tissue, over the past 60 years the study of sarcoma has been hampered by a lack of the patient and tumor resources needed to derive definitive conclusions. As compared with the more common malignancies of epithelial origin, there are relatively fewer centers in which basic, translational, clinical, and outcomes research focusing on sarcoma has been conducted. Nonetheless, students of sarcoma have found a receptive podium and audience under the aegis of Cancer, and it is striking that many of the classic and critical sarcoma reports of the past 60 years have seen the light of day via this journal. Moreover, many key developments over this same time period in the much larger field of oncology have been the result of groundbreaking sarcoma reports that have appeared in Cancer. Subjects as diverse as the viral and chemical etiology of solid tumors, the oncogenic impact of anticancer therapies, multimodality therapy of cancer, neoadjuvant systemic approaches to malignancy, function-preserving surgery, clinical and molecular prognosis, and the development of staging systems are all examples of critical concepts introduced by sarcoma-oriented research reports that have appeared in Cancer over the past 60 years. The contributions in 3 broad categories of emphasis will form the basis of this review article. These include: sarcoma clinical and research biology, sarcoma prognosis and staging, and the treatment of sarcoma. Greater than 150 sarcoma research reports have appeared in Cancer to date. In keeping with the historical orientation of this review, this analysis will focus on contributions that have had a significant impact in sarcoma oncology, particularly highlighting reports that are more than 30 years All quotations were reprinted with the permission

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“…For soft tissue sarcoma of the lower extremities, distant metastases were the direct cause of death in 90°,o of cases. Although soft tissue sarcomas were initially considered to be radio-resistant turnouts, there are a number of reports in the literature of good regressions [21][22][23]. Thus, radiation therapy may have, in certain cases, a place in the palliative management of advanced sarcomas.…”

Section: Introductionmentioning

confidence: 99%