Objective: To develop a cognitive-behavioral group therapy protocol and to verify its efficacy to reduce obsessivecompulsive symptoms.Methods: An open clinical trial with 32 obsessive-compulsive patients was performed, in which a cognitivebehavioral group therapy protocol of 12 weekly sessions of two hours, in 5 consecutive groups, was applied. The severity of symptoms was rated with the Yale-Brown Obsessive-Compulsive (Y-BOCS), Hamilton Anxiety (HAM A) and Hamilton Depression (HAM D) scales. The patients were followed up for 3 months after the end of the treatment. Results: There was a significant reduction in the scores of Y-BOCS, HAM A and HAM D scales with the treatment regardless the use of anti-obsessive medications. The rate of improved patients (decrease of ≥35% in Y-BOCS) was 78.1%. Two patients (6.25%) dropped out from the study. The effect size calculated for the Y-BOCS scale was 1.75. Conclusions: This study suggests that cognitive-behavioral group therapy reduces obsessive-compulsive symptoms. In addition, patients presented good compliance.Obsessive-compulsive disorder. Behavior therapy. Cognitive therapy. Group therapy.Objetivos: Desenvolver um protocolo de terapia cognitivo-comportamental em grupo e verificar sua eficácia em reduzir os sintomas obsessivo-compulsivos. Métodos: Foi realizado um ensaio clínico não controlado com 32 pacientes portadores de transtorno obsessivocompulsivo, com aplicação de um protocolo de terapia cognitivo-comportamental em grupo, de 12 sessões semanais de duas horas, em cinco grupos sucessivos. Os pacientes foram avaliados pela escalas Yale-Brown