Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure

Ito, Taihei; Kenmochi, Takashi; Aida, Naohiro; Kurihara, Kei; Kawai, Maki

doi:10.1016/j.transproceed.2018.06.014

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…With regard to the life prognosis of type 1 diabetes patients with end-stage renal failure, which has a very poor impact on the life prognosis, even preceding kidney transplantation alone improves patient survival. Our previous report showed that the one-, three-, and five-year survival rates of patients waiting for SPK were 98.4%, 92.1%, and 88.0%, respectively, while those of patients waiting for PAK (which means they had previously undergone kidney transplantation alone) were 100%, 96.6%, and 96.6%, respectively [23]. In addition, Mohan et al [24] showed that PAK had an additional positive impact on the life prognosis of type 1 diabetic patients with renal failure in comparison to renal transplantation alone.…”

Section: Discussionmentioning

confidence: 99%

Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry

Ito

Kenmochi

Aida

et al. 2020

JCM

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Background: The impact of pancreas transplantation, including kidney transplantation on patients’ life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation. Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Results: The survival rates at 1, 5, and 10 years on the waiting list were 98.4%, 90.3%, and 78.1%, respectively, while those after transplantation were significantly improved (p = 0.029) at 100%, 97.5%, and 88.9%, respectively. Furthermore, the survival rates of patients waiting for simultaneous pancreas and kidney transplantation (SPK) at 1, 5, and 10 years were 98.2%, 89.4%, and 75.4%, respectively, while those after SPK were also significantly improved (p = 0.026) at 100%, 94.6%, and 88.8%. The multivariable analysis revealed that the duration of diabetes before surgery was the only independent risk factor (hazard ratio = 1.095, p = 0.012) that affected the patient survival after SPK. Conclusion: Pancreas transplantation was found to improve the life prognosis of patients with type 1 diabetes, especially those with end-stage renal failure waiting for SPK.

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Section: Discussionmentioning

confidence: 99%

Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry

Ito

Kenmochi

Aida

et al. 2020

JCM

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“…Ito et al reported that immunosuppressive therapy using ATG resulted in reduced rejection in PAK cases. 25 This may indicate that immunosuppressive therapy is useful for regulating immunological rejection in PAK/PTA.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is clinically important to prevent the frequent development of pancreas graft immunogenic loss. Ito et al reported that immunosuppressive therapy using ATG resulted in reduced rejection in PAK cases 25. This may indicate that immunosuppressive therapy is useful for regulating immunological rejection in PAK/PTA.Note: Data are presented as number of patients (percentage).Abbreviations: PAK, pancreas-after-kidney transplantation; PTA, pancreas transplantation alone; PTx, pancreas transplantation; SPK, simultaneous pancreas-kidney transplantation.…”

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confidence: 99%

Current state of pancreas transplantation in Japan based on the nationwide registry

Tomimaru

Eguchi

Doki

et al. 2021

Annals of Gastroent Surgery

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“…Our study is limited by the number of cases being insufficient for examinations by each surgical procedure. In Japan, the pancreatic graft survival rates of PAK and PTA are markedly poorer than those of SPK [4,30]. Accumulating more cases of pancreas transplantation will enable the investigation of factors affecting the pancreatic graft survival by each surgical procedure in greater detail, which will consequently improve pancreatic transplantation.…”

Section: Hazards Ratiomentioning

confidence: 99%

Are the outcomes of Japanese pancreas transplantation utilizing extended‐criteria donors acceptable? A propensity score matching analysis for donors <50 or ≥50 years old

et al. 2020

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Summary In Japan, about 30% of pancreatic transplant donors are ≥50 years old, making them “extended‐criteria donors (ECDs).” We analyzed 361 cases of transplantation involving donors from the Japanese pancreas transplantation registry to evaluate the acceptability of ECDs. The patient survival rates at 1, 5, and 10 years after transplantation were 96.6%, 94.9%, and 88.3%, respectively. The survival rates of pancreas and kidney grafts at 1, 5, and 10 years were 85.3%, 74.8%, and 70.6%, and 94.2%, 90.9%, and 80.9%, respectively. Multivariate analysis revealed that no particular donor factors significantly influenced the pancreatic graft survival. Patients were divided into 2 groups: donors ≥50 years old (older group) and those <50 years old (younger group). After propensity score matching, the overall pancreatic graft survival at 1, 5, and 10 years after transplantation in the older group was 82.8%, 71.8%, and 69.5%, respectively, which was almost the same as in the younger group (84.9%, 70.2%, and 67.4%, respectively). No donor factors markedly influenced the pancreatic graft survival, and the outcomes of pancreas transplantation from ECDs ≥50 years old were comparable to those from younger donors.

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Effectiveness of Preceding Solo Kidney Transplantation for Type 1 Diabetes With End-Stage Renal Failure

Cited by 5 publications

References 10 publications

Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry

Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry

Current state of pancreas transplantation in Japan based on the nationwide registry

Are the outcomes of Japanese pancreas transplantation utilizing extended‐criteria donors acceptable? A propensity score matching analysis for donors <50 or ≥50 years old

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