Effectiveness of Pre-administered Natural Sweet-tasting Solution for Decreasing Pain Associated with Dental Injections in Children: A Split-mouth Randomized Controlled Trial

Gurunathan, Deepa; Janiani, Palak

doi:10.5005/jp-journals-10024-3224

Cited by 4 publications

(9 citation statements)

References 18 publications

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“…This distribution is shown in Figure 3. For this classification, 156 studies were taken into consideration, including wound treatment (33 studies) , metabolic disorders (33 studies) , oncology (17 studies) [108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124], respiratory conditions (13 studies) [125][126][127][128][129][130][131][132][133][134][135][136][137], oral health (14 studies) [138][139][140][141][142][143][144][145][146][147][148][149][150][151], surgery (11 studies) [152][153][154]…”

Section: Resultsmentioning

confidence: 99%

Geographical Origin Authentication—A Mandatory Step in the Efficient Involvement of Honey in Medical Treatment

Magdas,

David,

Hategan

et al. 2024

Foods

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Nowadays, in people’s perceptions, the return to roots in all aspects of life is an increasing temptation. This tendency has also been observed in the medical field, despite the availability of high-level medical services with many years of research, expertise, and trials. Equilibrium is found in the combination of the two tendencies through the inclusion of the scientific experience with the advantages and benefits provided by nature. It is well accepted that the nutritional and medicinal properties of honey are closely related to the botanical origin of the plants at the base of honey production. Despite this, people perceive honey as a natural and subsequently a simple product from a chemical point of view. In reality, honey is a very complex matrix containing more than 200 compounds having a high degree of compositional variability as function of its origin. Therefore, when discussing the nutritional and medicinal properties of honey, the importance of the geographical origin and its link to the honey’s composition, due to potential emerging contaminants such as Rare Earth Elements (REEs), should also be considered. This work offers a critical view on the use of honey as a natural superfood, in a direct relationship with its botanical and geographical origin.

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Section: Resultsmentioning

confidence: 99%

Geographical Origin Authentication—A Mandatory Step in the Efficient Involvement of Honey in Medical Treatment

Magdas,

David,

Hategan

et al. 2024

Foods

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“…For example, Ghaderi discovered that administering a sweet-tasting sucrose solution to children before dental injections decreased their level of pain and discomfort [ 38 ]. A sweet-tasting honey solution was identified to be useful by Janiani and Gurunathan D [ 39 ] for reducing pain during inferior alveolar nerve block and infiltration anesthesia. Using a CPT/C neurometer, Shiiba et al [ 40 ] investigated the impact of sweet taste stimulation on the oral mucosa pain tolerance threshold and discovered that, in children, but not in adults, stimulation increased the pain threshold.…”

Section: Discussionmentioning

confidence: 99%

Effect of cryoanesthesia and sweet tasting solution in reducing injection pain in pediatric patients aged 7–10 years: a randomized controlled trial

Davangere Padmanabh,

Gangurde,

Jhamb

et al. 2024

J Dent Anesth Pain Med

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Background The delivery of profound local anesthetics helps children receive successful treatment by reducing fear, anxiety, and discomfort during dental procedures. Local anesthetic injections are the most anticipated stimuli in dental surgery. Children's perceptions of pain can be altered by applying cryotherapy to precool the oral mucosa or by diverting their minds through taste distractions before administering local anesthetic injections. This study aimed to evaluate the efficacy of cryoanesthesia and xylitol sweet-tasting solution at the injection site in 7–10-year-old children. Methods A total of 42 participants, aged 7–10 years, who underwent dental treatment requiring local anesthesia, were enrolled in the study. The children were randomly divided into three groups. In group I, sterile water was held in the mouth for 2 minutes before anesthetic administration, similar to group II, and in group III, a xylitol sweet-tasting solution was used for 2 minutes before needle insertion. The analysis of pain perception was carried out based on the Visual Analog Scale (VAS) and the Sound, Eyes, and Motor (SEM) scale. For VAS analysis, a one-way analysis of variance (ANOVA) was performed for intergroup comparison, and a post hoc Tukey test was performed for subgroup analysis. For the categorical SEM scale, the Kruskal–Wallis test followed by the post hoc test was performed for intergroup comparison. Where a P value of <0.05 was considered statistically significant at 95% confidence intervals. Results Cryoanesthesia significantly reduced pain scores on VAS (4.21 ± 1.42) when compared to those on VAS with xylitol sweet-tasting solution (5.50 ± 1.40) and that with sterile water (6.14 ± 2.47). Intergroup comparison of the VAS scores among the three groups was performed using one-way ANOVA, which demonstrated statistically significant differences (P value <0.026) on the VAS scale. Intergroup comparison of the SEM scale was performed using the Kruskal–Wallis test, followed by post hoc comparison, which exhibited statistically significant differences (P < 0.007) among the three groups for the SEM scale. Conclusion Cryoanesthesia demonstrated higher efficacy in reducing injection pain than that exhibited by the xylitol sweet-tasting solution.

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“…Such reduction in pain scores has been reported in a study carried out on pediatric patients. 12 Moreover, one study suggests that adolescents were able to register lower levels of pain due to being able to suppress their pain of discomfort from dental injections. 21 However, many studies do report that adults appear to tolerate pain at a higher degree as compared to children due to a higher threshold for pain.…”

Section: Discussionmentioning

confidence: 99%

“…14 One of the purposed methods by which honey leads to a reduction in pain has been by when a sweet substance is administered, this leads to an increase in endogenous opioid production which led to a decrease in the perception of pain. 12 Therefore, this gives the idea that the chemical properties of the honey that are probably responsible for a decrease in pain associated with dental local anesthesia injection. Besides the use of ethyl chloride and honey, many different analgesic modalities have been used in literature such as topical anesthetics such as lidocaine and clove-papayabased gel.…”

Section: Discussionmentioning

confidence: 99%

“…11 Honey, a sweet flavored solution, has been used in clinical settings in pediatric patients by administrating orally as a modality to reduce the pain of dental injection. 12 Various studies have found that neonates that undergo venipuncture have reportedly benefitted from sweet solutions such as 30% sucrose prior to cutaneous procedures. 13 Few studies have evaluated the impact of administrating sweet solutions on analgesia that involves dental injections.…”

Section: Effectiveness Of Precooling With Ethyl Chloride Versus Honey...mentioning

confidence: 99%

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Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial

et al. 2023

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Objective: The objective of the study was to assess and compare the effectiveness of precooling with ethyl chloride versus honey in alleviating the pain of dental injection. Methods: About 90 patients were recruited for this randomized controlled trial. In each of the following three groups, 30 patients were allocated: Group 1, precooling with ethyl chloride; Group 2, honey; and Group 3, control. The pain score of patients in each group was measured after injecting the dental local anesthesia using a visual analog scale. Paired t-test and multiple linear regression tests were used for statistical analysis. A p value of ⩽0.05 was considered to be as significant. Results: The mean pain scores of participants residing in different groups were as follows: Group 1: 2.83 ± 1.46, Group 2: 4.33 ± 1.62, and Group 3: 7.80. After administrating ethyl chloride, the majority of the 18 (60%) patients reported to suffer from “mild pain.” Furthermore, in patients who were given honey in Group 2, most of the 21 (70%) patients reported suffering from “moderate pain.” In Group 3 (control) where no anesthetic modality was used, the majority of the 25 (83.33%) patients experienced “severe pain.” A significant difference was noted among the pain scores of three groups ( p = 0.001). Conclusion: The administration of local anesthetic is part of almost all dental procedures. Precooling with ethyl chloride resulted in a greater reduction in pain scores than honey upon administration of local anesthesia injection.

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Effectiveness of Pre-administered Natural Sweet-tasting Solution for Decreasing Pain Associated with Dental Injections in Children: A Split-mouth Randomized Controlled Trial

Cited by 4 publications

References 18 publications

Geographical Origin Authentication—A Mandatory Step in the Efficient Involvement of Honey in Medical Treatment

Geographical Origin Authentication—A Mandatory Step in the Efficient Involvement of Honey in Medical Treatment

Effect of cryoanesthesia and sweet tasting solution in reducing injection pain in pediatric patients aged 7–10 years: a randomized controlled trial

Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial

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