Effectiveness of polyamidoamine dendrimers modified with tripeptide growth factor, glycyl-l-histidyl-l-lysine, for enhancement of function of hepatoma cells

Kawase, Masaya; Kurikawa, Nobuya; Higashiyama, Shigeki; Miura, Nagamitsu; Shiomi, T.; Ozawa, Chitose; Mizoguchi, Tadashi; Yagi, Kiyohito

doi:10.1016/s1389-1723(99)80222-9

Cited by 15 publications

(4 citation statements)

References 16 publications

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“…This is considered to be advantageous for cell attachment or stimulation of cells via ligands. Fructose 11 and the tripeptide growth factor, glycyl-L-histidyl-L-lysine, 12 enhanced the function of hepatoma cells when they were used as ligands.…”

Section: Introductionmentioning

confidence: 99%

Suppression of apoptosis in hepatocytes by fructose‐modified dendrimers

Kawase

Shiomi

Matsui

et al. 2001

J. Biomed. Mater. Res.

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By immobilizing fructose-modified dendrimers on a polystyrene culture plate, the number of initially adhered hepatocytes on it was increased. Moreover, increasing the number of generations of fructose-modified dendrimer (fructose-dendrimer) increased the number. Urea synthesis per unit area also was increased, corresponding to the increase in the number of initially adhered hepatocytes. This result suggests that the fructose-dendrimers do not cause a decline in cell function. On the other hand, apoptosis of hepatocytes occurs during cultivation, and results in a decrease in the number of adhered cells and a decline in cell function. Fructose-dendrimers were found to suppress apoptosis of hepatocytes. This characteristic is considered to be responsible for the increase in the number of initially adhered hepatocytes without a decline in cell function. Fructose-dendrimers are shown to be very suitable scaffolds for use in a high-performance bioartificial liver support system.

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Section: Introductionmentioning

confidence: 99%

Suppression of apoptosis in hepatocytes by fructose‐modified dendrimers

Kawase

Shiomi

Matsui

et al. 2001

J. Biomed. Mater. Res.

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“…A few examples have been reported, and these are mainly related with applications in cell-adhesion studies as nanopatterning [233]. Interestingly, ligand-modified dendrimers have been proposed for use as substratum for cell culture and high performance bioartificial organs [234].…”

Section: Tissue Engineering (Te) Applications Of Dendrimers and Dendrmentioning

confidence: 99%

Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review

Oliveira

Salgado

Sousa

et al. 2010

Progress in Polymer Science

177

100

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a b s t r a c tSince the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, but many hot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host-guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century.

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“…The use of dendrimers' architectures in cells and TE applications is still in its infancy. Ligand-modified dendrimers have been proposed for use as substratum for cell culture and high performance bioartificial organs 82 . Dendrimers are used in bone, cartilage tissue engineering.…”

Section: Tissue Engineering (Te) Applications Of Dendrimersmentioning

confidence: 99%

Untitled

2011

IJPSR

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Dendrimers are unique class of the polymer which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Many drugs used in various therapies are facing difficulties like toxicity or nonspecific targeting. New delivery technologies could help to overcome this challenge. Nanostructures with uniform and well-defined particle size and shape are of eminent interest in biomedical applications because of their ability to cross cell membranes and to reduce the risk of premature clearance from the body. Hydrophobic drugs can be complex within the hydrophobic dendrimers interior to make them water-soluble or drugs can be covalently coupled onto the surface of the dendrimers. Structural features of this nanomolecule can be effectively modified for drug delivery in the field of pharmaceutical sciences and biotechnology. Present review deals with various applications along with relevant examples of dendrimers in brief.

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Effectiveness of polyamidoamine dendrimers modified with tripeptide growth factor, glycyl-l-histidyl-l-lysine, for enhancement of function of hepatoma cells

Cited by 15 publications

References 16 publications

Suppression of apoptosis in hepatocytes by fructose‐modified dendrimers

Suppression of apoptosis in hepatocytes by fructose‐modified dendrimers

Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review

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