Effectiveness of pneumococcal vaccine in patients with chronic obstructive pulmonary disease (COPD)

Mohanty, Thitta; Patro, Mahismita; Sahoo, Jyotirmaya; Meher, Bijaya Kumar; Pattnaik, Manoranjan; Patra, Jeetendra Kumar

doi:10.18203/2320-6012.ijrms20184433

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…While these may be the best outcomes to look at from a vaccine efficacy point of view, clinically relevant outcomes for COPD patients would be exacerbation rates. A randomised, non-placebo controlled trial, however, showed decreased exacerbation rate in COPD patients after administration of a pneumococcal polyvalent vaccine [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

et al. 2023

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BackgroundInfectious exacerbations are crucial events that dictate the natural course of COPD patients. Pneumococcal vaccination has shown to decrease incidence of community acquired pneumonia in COPD patients. There is paucity of data on outcomes of hospitalisation in pneumococcal vaccinated COPD patients in comparison with unvaccinated subjects.ObjectivesTo evaluate the difference in hospitalisation outcomes in pneumococcal vaccinatedversusunvaccinated COPD subjects hospitalized with Acute Exacerbation.MethodsThis was a prospective analytical study on 120 subjects hospitalised with acute COPD exacerbation. 60 patients with prior pneumococcal vaccination and 60 unvaccinated patients were recruited. Outcomes of hospitalisation like mortality rate, need for assisted ventilation, length of hospital stay, need for ICU care, and length of ICU stay were collected and compared between two groups with appropriate statistical tools.Results60% of unvaccinated patients (36/60) required assisted ventilation whereas only 43.3% of vaccinated subjects (26/60) needed assisted ventilation (p value 0.04). Most of the secondary outcomes were better in the vaccinated group. The mean length of ICU stay in the vaccinated group was 0.67 days (±1.11) compared to 1.77 (± 1.89) in the unvaccinated group. The mean length of hospital stay was 4.50 days (±1.64) and 5.47 days (±2.03) days in vaccinated and unvaccinated group respectively (p value 0.005).ConclusionsCOPD patients who have received prior pneumococcal vaccination have better outcomes when they are hospitalised for an acute exacerbation. Pneumococcal vaccination may be recommended for all patients with COPD who are at risk of hospitalisation with acute exacerbation.

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Section: Introductionmentioning

confidence: 99%

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

et al. 2023

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Severity of Exacerbation in Pneumococcal Vaccinated versus Unvaccinated Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Post hoc Analysis of Presentation Status of the Subjects of HOPE Chronic Obstructive Pulmonary Disease Study

Venkitakrishnan,

Vijay,

Ramachandran

et al. 2024

Journal of Advanced Lung Health

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Background: Acute exacerbations occur with varying frequency and severity and impact the natural course of chronic obstructive pulmonary disease (COPD) patients. Pneumococcal vaccination has been shown to decrease the incidence of community-acquired pneumonia and exacerbation rate in COPD patients. There is a paucity of data on the influence of pneumococcal conjugate vaccination on the severity of COPD exacerbations. Objectives: The objectives of this study were to evaluate the severity of exacerbation in pneumococcal vaccinated (vaccinated with 13-valent conjugate vaccine) versus unvaccinated COPD subjects hospitalized with acute exacerbation. Materials and Methods: This was a post hoc analysis of the severity of exacerbation in the subjects of HOPE COPD study. This involved the collection of clinical, radiological, and laboratory data of 120 COPD patients who were hospitalized with an acute exacerbation, 60 of whom had prior pneumococcal vaccination and 60 were unvaccinated. Data of COPD patients at the time of presentation with acute exacerbation were analyzed. Comparison was made between severity parameters such as presence of fever, leukocytosis, respiratory failure, multilobar consolidation, hypotension needing inotropic support, and presence of sepsis between pneumococcal vaccinated and unvaccinated subjects. Results: The occurrence of multilobar consolidation was substantially less in the vaccinated group (60% vs. 6.7%; P = 0.0001). The incidence of fever, leukocytosis, and elevated C-reactive protein was significantly higher in the unvaccinated group. Need for intensive care unit care was higher in the unvaccinated group (58.3% vs. 30% with P = 0.019). The occurrence of new-onset respiratory failure was similar in both the groups although type 2 failure with respiratory acidosis was more in the unvaccinated group. Patients in the unvaccinated group had a higher incidence of sepsis and need for inotropic support as well as assisted ventilation. Conclusions: Prior immunization with 13-valent pneumococcal conjugate vaccine ameliorates the severity of exacerbation in COPD patients needing hospitalization. Pneumococcal vaccination may be recommended for all patients with COPD who are at risk of hospitalization with acute exacerbation.

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Effectiveness of pneumococcal vaccine in patients with chronic obstructive pulmonary disease (COPD)

Cited by 2 publications

References 7 publications

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

Severity of Exacerbation in Pneumococcal Vaccinated versus Unvaccinated Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Post hoc Analysis of Presentation Status of the Subjects of HOPE Chronic Obstructive Pulmonary Disease Study

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