Effectiveness of physicochemical techniques on the activation of Ti6Al4V surface with improved biocompatibility and antibacterial properties

Olmo, Jon Andrade del; Alonso, José María Rabal; Ronco-Campaña, Alejandro; Sáez-Martínez, Virginia; Pérez-González, Raúl; Rothnie, Alice; Tighe, Brian; Vilas-Vilela, José Luis; Pérez‐Álvarez, Leyre

doi:10.1016/j.surfcoat.2022.128821

Cited by 5 publications

(5 citation statements)

References 64 publications

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“…Recent studies exploring the improvements on host tissue response and antibacterial properties of various materials have highlighted the potential of surface modification technologies in limiting and preventing bacterial contamination, as well as to promote proper adhesion of cells and proteins [38,50]. Notably, surface chemical modifications of biomaterial, drug delivery as well as immobilization of bioactive molecules that can directly or indirectly control the activity of components of the immune system have emerged as effective approaches in this regard.…”

Section: Strategies For Combating Complicationsmentioning

confidence: 99%

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Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Sánchez-Bodón,

Diaz-Galbarriatu,

Pérez-Álvarez

et al. 2023

Coatings

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This paper reviews different approaches to obtain biomaterials with tailored functionalities and explains their significant characteristics that influence their bioactivity. The main goal of this discussion underscores the significance of surface properties in materials, with a particular emphasis on their role in facilitating cell adhesion in order to obtain good biocompatibility and biointegration, while preventing adverse effects, such as bacterial contamination and inflammation processes. Consequently, it is essential to design strategies and interventions that avoid bacterial infections, reducing inflammation and enhancing compatibility systems. Within this review, we elucidate the most prevalent techniques employed for surface modification, notably emphasizing surface chemical composition and coatings. In the case of surface chemical composition, we delve into four commonly applied approaches: hydrolysis, aminolysis, oxidation, and plasma treatment. On the other hand, coatings can be categorized based on their material composition, encompassing ceramic-based and polymer-based coatings. Both types of coatings have demonstrated efficacy in preventing bacterial contamination, promoting cell adhesion and improving biological properties of the surface. Furthermore, the addition of biological agents such as drugs, proteins, peptides, metallic ions plays a pivotal role in manifesting the prevention of bacterial infection, inflammatory responses, and coagulation mechanism.

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Section: Strategies For Combating Complicationsmentioning

confidence: 99%

“…proper adhesion of cells and proteins [38,50]. Notably, surface chemical modifications o biomaterial, drug delivery as well as immobilization of bioactive molecules that can di rectly or indirectly control the activity of components of the immune system hav emerged as effective approaches in this regard.…”

Section: Strategies For Combating Complicationsmentioning

confidence: 99%

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Sánchez-Bodón,

Diaz-Galbarriatu,

Pérez-Álvarez

et al. 2023

Coatings

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, these materials are deprived of suitable mechanical properties due to their brittleness and low fracture strength [ 17 ]. In this regard, metallic materials, biologically neutral in response with excellent mechanical performance, are considered the most suitable materials [ 18 ]. Implants based on metals such as stainless steel, titanium-based alloys, and cobalt-based alloys are the most common orthopedic implant materials due to their cost-effectiveness, excellent durability, and desirable mechanical properties [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the Ti6A14V alloy exhibits certain drawbacks such as lack of antibacterial activity and hemocompatibility, indicating cellular toxicity that could lead to implant failure. In fact, cellular toxicity is related to the toxic aluminum and vanadium ions released in the human body, potentially causing cell death, interference with bone mineralization, allergic reactions, Alzheimer's disease, microcytic anemia, and neurotoxicity [ 18 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bioactivity and antibacterial properties of Ti6Al4V-based green biocomposite implant encompassing TiO2 nanotube arrays and garlic extract

Jebeli,

Aghdam,

Najjari

et al. 2024

Heliyon

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“…Surface tuning is largely used to improve biocompatibility of implantable materials. For instance, the surface oxidation of the TiO 2 layer on a Ti-based biomaterial and the creation of active hydroxyl groups (Ti-OH) was recently exploited to improve cytocompatibility, cell proliferation, and hemocompatibility, with respect to the pristine alloy [33].…”

Section: Introductionmentioning

confidence: 99%

Physico-Chemical Approaches to Investigate Surface Hydroxyls as Determinants of Molecular Initiating Events in Oxide Particle Toxicity

Pavan

Santalucia

Escolano-Casado

et al. 2023

IJMS

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The study of molecular recognition patterns is crucial for understanding the interactions between inorganic (nano)particles and biomolecules. In this review we focus on hydroxyls (OH) exposed at the surface of oxide particles (OxPs) which can play a key role in molecular initiating events leading to OxPs toxicity. We discuss here the main analytical methods available to characterize surface OH from a quantitative and qualitative point of view, covering thermogravimetry, titration, ζ potential measurements, and spectroscopic approaches (NMR, XPS). The importance of modelling techniques (MD, DFT) for an atomistic description of the interactions between membranes/proteins and OxPs surfaces is also discussed. From this background, we distilled a new approach methodology (NAM) based on the combination of IR spectroscopy and bioanalytical assays to investigate the molecular interactions of OxPs with biomolecules and membranes. This NAM has been already successfully applied to SiO2 particles to identify the OH patterns responsible for the OxPs’ toxicity and can be conceivably extended to other surface-hydroxylated oxides.

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Effectiveness of physicochemical techniques on the activation of Ti6Al4V surface with improved biocompatibility and antibacterial properties

Cited by 5 publications

References 64 publications

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Evaluation of bioactivity and antibacterial properties of Ti6Al4V-based green biocomposite implant encompassing TiO2 nanotube arrays and garlic extract

Physico-Chemical Approaches to Investigate Surface Hydroxyls as Determinants of Molecular Initiating Events in Oxide Particle Toxicity

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