Effectiveness of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus -A systematic review

Nagi, Ravleen; Muthukrishnan, Arvind; Rakesh, N

doi:10.1016/j.jobcr.2023.03.003

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…Furthermore, four of the studies noted that PDT was more effective than topical corticosteroids in reducing the signs and symptoms of OLP, with a p -value < 0.01. 25 Another systematic review by Al-Maweri et al also found that PDT was a successful treatment option for patients with symptomatic OLP. 11 …”

Section: Discussionmentioning

confidence: 98%

Case Report: Recalcitrant oral lichen planus involving bilaterally buccal mucosae treated with a combination of photodynamic and photobiomodulation therapies

Trakarnboonkij,

Tanya,

Sarideechaigul

et al. 2024

F1000Res

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Background Managing recalcitrant oral lichen planus (OLP) can be challenging. Laser therapy has been suggested as an alternative to corticosteroids for treatment. Photodynamic therapy (PDT) is a non-invasive technique that enables the removal of lesions without surgery. Photobiomodulation therapy (PBMT) can promote healing and recovery of the lesions. Case presentation The objective was to treat unresponsive bilateral OLP of the whole buccal mucosae with a combination of PDT and PBMT. Results A 43-year-old Thai male presented with the severe painful reticular type of OLP of bilateral buccal mucosae involving upper and lower vestibular areas. The lesions were not remitted with either prednisolone systemic steroids or fluocinolone topical corticosteroids. After undergoing ten sessions of PDT with 10% 5-Aminolevulinic acid (5-ALA) in the form of thermoplastic gel and a 635 nm diode laser at 100 to 400 mW with an energy density of 20 to 30 J/cm2 in continuous wave mode, combined with five interim-sessions of PBMT using a 635 nm diode laser at 200 to 300 mW with an energy density of 6 to 10 J/cm2 in continuous wave, the patient reported relief of burning sensation beside remission of lesions without any complications. Conclusion The wide-spreading recalcitrant OLP with burning sensation can be managed by combining PDT and PBMT.

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Section: Discussionmentioning

confidence: 98%

Case Report: Recalcitrant oral lichen planus involving bilaterally buccal mucosae treated with a combination of photodynamic and photobiomodulation therapies

Trakarnboonkij,

Tanya,

Sarideechaigul

et al. 2024

F1000Res

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“…35 Nd:YAG laser, low-dose excimer laser (308nm), apremilast (used for psoriasis, psoriatic arthritis, Behcet's disease), and ustekinumab (human monoclonal antibody) are other therapeutic options. 36,37 Treatment of oral lichen planus (OLP) is challenging and mainly symptomatic, aiming to reduce the risk of malignant transformation. In OLP, the first-line treatment involves the application of potent steroids, available in the form of ointments, adhesive pastes, mouthwash solutions, or aerosols.…”

Section: Treatment and Managmentmentioning

confidence: 99%

Lichen planus: A Systematic Review

Garbacz,

Maciąg,

Pasztelan

et al. 2024

J Educ Health Sport

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Lichen planus (LP) is a chronic skin, mucous membrane, and nail disease. Lichen planus is a rare skin condition occurring in less than 1% of the general population, affecting both children and adults. Oral lichen planus (OLP) involvement is much more common. It is an autoimmune disease caused by T lymphocytes, with epigenetic factors playing a significant role in the development of autoimmune skin diseases. MicroRNAs (miRNAs), a group of non-coding RNAs, play a substantial role in regulating the immune response.1 The etiology of lichen planus in not fully understood. It can be triggered by antihypertensive drugs, beta-blockers, infections, viral hepatitis, psychological stress, and others. Cases of lichen planus appearing after recovering from COVID-19 have been reported, as well as a significant increase in cases after COVID-19 vaccination.2–5 Diagnosis is based on clinical presenstation and characteristic histopathological findings. The disease is often self-limiting, accompanied by persistent itching and painful erosions of the mucous membrane, affecting the patient’s quality of life and mental well-being. First-line treatments inculde topical corticosteroids and/or oral corticosteroids. There are reports of new potential treatments, such as biologic drugs (anti-IL12/13, anti-IL17) and Janus kinase inhibitors. Consequently, a dramatic change in lichen planus treatment can be expected in the near future. The majority of patients suffering from lichen planus develop metabolic syndrome which is the cause of other diseases. This article provides a comprehensive overview of current knowledge about lichen planus and its variants.

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“…33 Using ML techniques such ANN, SVM, RF, and DT, a diagnostic model based on lateral cephalometric radiographs was developed to measure cervical vertebral maturation. 34 Convoluted Neural Network powered AI/AuI system analysis showed a tracing accuracy of over 90% and came to the conclusion that automated identification was more trustworthy than manual identification. 35 In the future, more precise and accurate automated cephalometric analysis should be possible thanks to hybrid methodologies that combine ML and knowledge-based algorithms.…”

Section: Orthodonticsmentioning

confidence: 99%

A brief exploration of artificial intelligence in dental healthcare: a narrative review

Kamath,

Saldanha

et al. 2024

F1000Res

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Artificial intelligence is a computer system which can replicate human behavior and largely supports human actions and interpretation, but not replace human responses. Over the past few decades, the field of artificial intelligence (AI) has experienced phenomenal development and expansion. We are surrounded by several instances of AI. AI has applications in different branches of Dentistry. A total of 59 papers from an electronic search using Google Scholar and PubMed were used to create this narrative review. Artificial intelligence can be utilised for diagnosis, decision-making, treatment planning, early detection and prevention of oral disease, and finally result prediction by utilising cutting-edge technology in imaging. It shows how dentists can use it as a useful tool at various phases of clinical cases. The future of AI in dentistry appears to be outstanding with advancements in full artificial intelligence technology, dental assistance, and dental instructional tools. In order to help dental professionals better grasp AI as a tool to assist their work with enhanced efficiency, investigations need to be done to uncover patterns and foresee future related to oral health concerns. This review article attempts to highlight these points and lays an emphasis on how AI is driving dentistry in the present and will improve dental care in the future.

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Effectiveness of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus -A systematic review

Cited by 9 publications

References 18 publications

Case Report: Recalcitrant oral lichen planus involving bilaterally buccal mucosae treated with a combination of photodynamic and photobiomodulation therapies

Case Report: Recalcitrant oral lichen planus involving bilaterally buccal mucosae treated with a combination of photodynamic and photobiomodulation therapies

Lichen planus: A Systematic Review

A brief exploration of artificial intelligence in dental healthcare: a narrative review

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