Effectiveness of Pharmacological Or Psychological Interventions for Smoking Cessation in Smokers with Major Depression Or Depressive Symptoms: A Systematic Review of the Literature

Abstract

More research is needed into effectively addressing smoking in people with concurrent mental disorder. Data currently available need to be confirmed in randomized trials aimed at replicating the results and disentangling the effects of each therapeutic ingredient when a combination therapy is proposed. Studies on tolerability of treatments are warranted, as well as those aimed at identifying factors of vulnerability to adverse effects.

Remission from nicotine dependence among people with severe mental illness who received help/services for tobacco/nicotine use

“…Our findings were consistent with previous studies that found an association between receiving services for tobacco/nicotine use and nicotine dependence remission (Aldi et al, 2018; Annamalai et al, 2015; Rüther et al, 2014; Stubbs, Vancampfort, Bobes, De Hert, & Mitchell, 2015). In addition, the current study extends the prior research with population‐based data.…”

“…This might be partially related to the health care providers' lack of knowledge of effective programs and tobacco/nicotine use treatment strategies for those with SMI (Missen, Brannelly, & Newton‐Howes, 2013; Rae, Pettey, Aubry, & Stol, 2015). However, evidence from clinical trials suggests that pharmacological services alone or combined with behavioral and psychological support is effective for tobacco/nicotine use and tolerated by smokers with SMI (Aldi, Bertoli, Ferraro, Pezzuto, & Cosci, 2018; Anthenelli et al, 2013; Dubrava & Anthenelli, 2018; Hall et al, 2006; Secades‐Villa, González‐Roz, García‐Pérez, & Becoña, 2017; Tidey & Rohsenow, 2009; Tsoi, Porwal, & Webster, 2013; Williams et al, 2012)…”

“…Prior evaluations of therapeutic interventions for nicotine dependence in people with SMI recommend pharmacological services to aid smoking cessation (Aldi et al, 2018; Anghelescu, 2009; Annamalai, Singh, & O'Malley, 2015; Cather et al, 2013; Cerimele & Durango, 2012; Evins et al, 2014; Jun, Tian‐liang, Bin, & Xian‐wei, 2009; Rüther et al, 2014; Williams et al, 2012). Recent systematic review and meta‐analyses suggest the effectiveness of behavioral services, such as acupressure and acupuncture combined with counseling, in smoking cessation (Wang et al, 2019; Zulkifly & Amin, 2019).…”

“…This might be partially related to the health care providers' lack of knowledge of effective programs and tobacco/nicotine use treatment strategies for those with SMI (Missen, Brannelly, & Newton-Howes, 2013;Rae, Pettey, Aubry, & Stol, 2015). However, evidence from clinical trials suggests that pharmacological services alone or combined with behavioral and psychological support is effective for tobacco/nicotine use and tolerated by smokers with SMI (Aldi, Bertoli, Ferraro, Pezzuto, & Cosci, 2018;Anthenelli et al, 2013;Dubrava & Anthenelli, 2018;Hall et al, 2006;Secades-Villa, González-Roz, García-Pérez, & Becoña, 2017;Tidey & Rohsenow, 2009;Tsoi, Porwal, & Webster, 2013;Williams et al, 2012) Prior evaluations of therapeutic interventions for nicotine dependence in people with SMI recommend pharmacological services to aid smoking cessation (Aldi et al, 2018;Anghelescu, 2009;Annamalai, Singh, & O'Malley, 2015;Cather et al, 2013;Cerimele & Durango, 2012;Evins et al, 2014;Jun, Tian-liang, Bin, & Xianwei, 2009;Rüther et al, 2014;Williams et al, 2012). Recent systematic review and meta-analyses suggest the effectiveness of behavioral services, such as acupressure and acupuncture combined with counseling, in smoking cessation (Wang et al, 2019;Zulkifly & Amin, 2019).…”

Smoking load reduction is insufficient to downregulate miR-301b, a lung cancer promoter

“…Other aspects could have contributed to these results, such as the use of medications, morbidities, and the period of follow-up. The first-line pharmacological treatment for smoking cessation in most countries is varenicline and nicotine replacement combined with cognitive-behavioural therapy, the combination of therapies are more effective than isolated drugs in smokers, with depression and smokers with chronic obstructive pulmonar disease [54][55][56] . www.nature.com/scientificreports/…”