Effectiveness of oral vitamin D supplementation in lessening disease severity among patients with psoriasis: A systematic review and meta-analysis of randomized controlled trials

Theodoridis, Xenophon; Grammatikopoulou, Maria G.; Stamouli, Eleni-Maria; Talimtzi, Persefoni; Pagkalidou, Eirini; Zafiriou, Efterpi; Haidich, Anna‐Bettina; Bogdanos, Dimitrios P.

doi:10.1016/j.nut.2020.111024

Cited by 23 publications

(23 citation statements)

References 39 publications

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“…Moreover, some reports have shown marked clinical improvement in patients with psoriasis who received up to 50,000 IUs per day of oral vitamin D 3 [ 97 , 98 , 99 ]. However, the benefit of lower doses of up to 4200 IUs per day or equivalent of vitamin D supplements for the treatment of psoriasis is still unverified based on the results of a few clinical trials [ 100 ].…”

Section: Evidence On Vitamin D For Prevention and Treatment Of Rheumatic Diseasesmentioning

confidence: 99%

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Charoenngam

2021

IJMS

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Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also considered an immunomodulatory agent that regulates innate and adaptive immune systems. The aim of this narrative review is to provide general concepts of vitamin D for the skeletal and immune health, and to summarize the mechanistic, epidemiological, and clinical evidence on the relationship between vitamin D and rheumatic diseases. Multiple observational studies have demonstrated the association between a low level of serum 25-hydroxyvitamin D [25(OH)D] and the presence and severity of several rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthropathies, and osteoarthritis (OA). Nevertheless, the specific benefits of vitamin D supplements for the treatment and prevention of rheumatic diseases are less accepted as the results from randomized clinical trials are inconsistent, although some conceivable benefits of vitamin D for the improvement of disease activity of RA, SLE, and OA have been demonstrated in meta-analyses. It is also possible that some individuals might benefit from vitamin D differently than others, as inter-individual difference in responsiveness to vitamin D supplementation has been observed in genomic studies. Although the optimal level of serum 25(OH)D is still debatable, it is advisable it is advisable that patients with rheumatic diseases should maintain a serum 25(OH)D level of at least 30 ng/mL (75 nmol/L) to prevent osteomalacia, secondary osteoporosis, and fracture, and possibly 40–60 ng/mL (100–150 nmol/L) to achieve maximal benefit from vitamin D for immune health and overall health.

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Section: Evidence On Vitamin D For Prevention and Treatment Of Rheumatic Diseasesmentioning

confidence: 99%

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Charoenngam

2021

IJMS

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“…In comparison, there was no difference between psoriasis respondents and controls in consumption of eicosapentaenoic acid (EPA) (0.04±0.11 and 0.04±0.09, respectively; p = 0.131) or docosahexaenoic acid (DHA) (0.08±0.16 and 0.07±0.15, respectively; p = 0.319) Dietary intake of ETA trends remained after controlling for gender, age, veteran status, marital status, ratio for family income to poverty, BMI, alcohol intake, and smoking in trend test of association. Oral Vitamin D Theodoridis et al 2021 79 Meta-analysis 4 RCTs (Jarrett 2017, Ingram 2018, Disphanural 2019, Siddiqui 1990) of at least 3 months duration using orla vitamin D supplements compared to placebo 3 trials (Jarrett 2017, Ingram 2018, Disphanural 2019) used for quantitative synthesis of PASI Intervention, n = 109 Control, n = 96 Vitamin D in various dosages (see individual studies) Placebo (see individual studies) PASI scoring was significantly decreased in the oral vitamin D treatment group, with a mean difference of −0.92 (95% CI: −1.72 to −0.11). After applying the Hartung-Knapp adjustment for random effects, PASI scoring was not significantly different between groups (−0.92, 95% CI: −2.21 to 0.38).…”

Section: Resultsmentioning

confidence: 99%

Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives

Chung¹,

Bartholomew²,

Yeroushalmi³

et al. 2022

PTT

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Nutrition is a complex topic encompassing diet and a variety of supplements including vitamins, fish oil, herbal products, and probiotics. Patients with psoriasis display high interest in understanding the potential impact of nutritional modifications on their psoriasis. In this review, we examine the evidence for nutritional interventions in psoriasis and summarize important concepts. We found that certain diets, such as low-calorie diets for obese patients, gluten-free diets for patients with comorbid celiac disease, and the Mediterranean diet, may have benefits for psoriasis patients. Supplements in general do not show strong evidence of benefit, though more studies are required given the heterogeneity of these trials. Finally, the gut microbiome has drawn considerable interest in recent years, with specific probiotics showing promising results for psoriasis patients and warranting further exploration.

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“…Consequently, vitamin D and its analogs are considered as important factors supporting eradication of psoriatic plaques [ 144 , 145 ]. Several studies have proved that vitamin D analogs could be successfully used as supplements to compensate for vitamin D deficiency [ 146 , 147 ]; they could also be used directly through topical application [ 148 , 149 ]. Recently, high doses of vitamin D were found to be efficient in eradication of psoriatic plaques [ 150 ].…”

Section: Sunlight Deficiency Influences Psoriasis and Depressionmentioning

confidence: 99%

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

Marek-Józefowicz

Czajkowski

Borkowska

et al. 2022

IJMS

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Psoriasis is a chronic inflammatory skin disease with systemic manifestation, in which psychological factors play an important role. The etiology of psoriasis is complex and multifactorial, including genetic background and environmental factors such as emotional or physical stress. Psychological stress may also play a role in exacerbation of psoriasis, by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic–adrenal–medullary axis, peripheral nervous system, and immune system. Skin cells also express various neuropeptides and hormones in response to stress, including the fully functional analog of the HPA axis. The deterioration of psoriatic lesions is accompanied by increased production of inflammatory mediators, which could contribute to the imbalance of neurotransmitters and the development of symptoms of depression and anxiety. Therefore, deregulation of the crosstalk between endocrine, paracrine, and autocrine stress signaling pathways contributes to clinical manifestations of psoriasis, which requires multidisciplinary approaches.

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Effectiveness of oral vitamin D supplementation in lessening disease severity among patients with psoriasis: A systematic review and meta-analysis of randomized controlled trials

Cited by 23 publications

References 39 publications

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

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