Effectiveness of Oral Sucrose for Pain Management in Infants During Immunizations

Curry, Donna M.; Brown, Cindy; Wrona, Sharon

doi:10.1016/j.pmn.2010.07.008

Cited by 23 publications

(16 citation statements)

References 39 publications

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“…In 2012, Carrie and colleagues conducted a study to assess the effect of 50% and 75% oral sucrose on vaccineinduced pain in 2, 4, and 6 month-old children. The results of this study showed that there was no significant difference between age groups in terms of pain score and crying time (16).…”

Section: Introductionmentioning

confidence: 56%

Comparison of the Effects of Oral Sucrose 30% and 50% on the Pain of Injection of Hepatitis B Vaccine in Newborns

Imani

Moradi

2019

Zahedan J Res Med Sci

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Background: Uncontrolled pain in newborns results in permanent damage to the growth components of cognitive development and changes in response to subsequent painful stimuli. Objectives: The aim of this study was to comparison of the effects of oral sucrose 30% and 50% on the pain of injection of hepatitis B vaccine in newborns. Methods: In these triple-blind clinical trial conducted at Amir-al Momenin Hospital in Semnan, 91 term infants were selected and randomly divided into three groups. Two minutes prior to intramuscular injection of hepatitis B vaccine in the case group, 2 mL of sucrose solution 30% or 50% and in the control group the same volume of sterile water was given orally to the infant. Prior to the administration of sucrose, immediately after injection and 5 minutes after injection the Neonatal Infant Pain Scale (NIPS) was used to assess pain. For statistical data analysis, Mann-Whitney, chi-square, Kruskal-Wallis, One-Way ANOVA and Dunnett tests at a significance level of 5% were used. Results: The results showed that sucrose 30% and 50% significantly reduced pain during, immediately, and 5 minutes after injection (P < 0.05). Conclusions: In general, high concentrations of sucrose can relieve the pain of vaccination and can be used in the clinic.

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Section: Introductionmentioning

confidence: 56%

Comparison of the Effects of Oral Sucrose 30% and 50% on the Pain of Injection of Hepatitis B Vaccine in Newborns

Imani

Moradi

2019

Zahedan J Res Med Sci

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“…Similarly, a case control study was conducted by Curry DM in 2012, to examine the effects of oral sucrose as an analgesic agent during routine immunizations in infants at 2, 4 and 6 months of age. 16 It showed no significant difference. Consolability factors might be responsible for such results in these studies.…”

Section: Resultsmentioning

confidence: 88%

Comparison of the effectiveness of oral sucrose solution and topical anaesthetics during immunization in infants between age 6 weeks-6 months

Kumar

Narang

Singh

et al. 2019

Int J Contemp Pediatr

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Background: Routine childhood immunization is a proven tool for eradicating and controlling infectious diseases. Despite its key role in maintaining global public health, many individuals either refuse or delay immunization because of pain from the needle puncture. Several methods have been employed to reduce injection pain during immunization in children.Methods: Study comprised of 210 healthy infants coming for immunizations. They were divided into three groups A, B and C having equal number of infants. Group A was given oral sucrose solution, group B was given topical anaesthetic prior to immunization; whereas group C acted as controls. Response to pain was recorded among the three groups and findings were analyzed.Results: Infants enrolled in group A, i.e. those who were given 24% oral sucrose solution before immunization showed significant reduction in pain (measured by modified behaviour pain scale) as compared to control group at 15 seconds and 60 seconds of injection administration. Infants enrolled in group B, i.e. those who were sprayed topical local anaesthetics (10% lignocaine spray) before immunization showed significant reduction in pain as compared to control group at 15 seconds and 60 seconds of injection administration.Conclusions: Administration of oral sucrose solution and application of topical local anaesthetics are effective measures to reduce injection pain during immunization. Administration of oral sucrose solution before immunization showed greater reduction in pain as compared to application of topical local anaesthetics in present study.

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“…However, a study by Hatfield et al (2008) did not find that sucrose reduced or eliminated pain during immunisations unless other measures were employed concurrently; namely, comfort measures, distraction, breast-feeding and the use of a pacifier supporting previous findings. Curry et al (2010), in a sample of 113 healthy infants, found there was no significant difference in the use of sucrose compared to water to reduce pain during immunisations. However, they later acknowledge that it is vital to consider the factors that influence the effect of sucrose which must be controlled for; i.e.…”

Section: Discussionmentioning

confidence: 95%

Promoting the use of sucrose as analgesia for procedural pain management in neonates: A review of the current literature

Cooper

Petty

2012

Journal of Neonatal Nursing

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Effectiveness of Oral Sucrose for Pain Management in Infants During Immunizations

Cited by 23 publications

References 39 publications

Comparison of the Effects of Oral Sucrose 30% and 50% on the Pain of Injection of Hepatitis B Vaccine in Newborns

Comparison of the Effects of Oral Sucrose 30% and 50% on the Pain of Injection of Hepatitis B Vaccine in Newborns

Comparison of the effectiveness of oral sucrose solution and topical anaesthetics during immunization in infants between age 6 weeks-6 months

Promoting the use of sucrose as analgesia for procedural pain management in neonates: A review of the current literature

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