Effectiveness of oral pressure therapy in obstructive sleep apnea: a systematic analysis

Novel Intraoral Negative Airway Pressure in Drug-Induced Sleep Endoscopy with Target-Controlled Infusion

“…8 Oral pressure therapy (OPT) is an alternative treatment modality for patients with poor compliance to CPAP. [9][10][11][12][13] Nigam et al 10 reported that the OPT success rate (defined as a reduction of ≥50% from the baseline apnea-hypopnea index [AHI] and a post-OPT treatment residual AHI of ≤10) varies between 25% and 37%. However, the success rate does not correlate with OSA severity or the body mass index (BMI); 10,12 therefore, identifying responders and nonresponders to OPT treatment necessitates the establishment and comprehensive examination of predictors.…”

Treatments for obstructive sleep apnea: CPAP and beyond

“…97 In a review of the intervention, only 25% to 37% of patients had at least a 50% reduction in the AHI and a residual AHI of 10 or less, and a substantial number of patients still had significant obstructive sleep apnea. 71 The baseline severity of sleep apnea did not correlate with success. 71 Negative external pressure Continuous negative expiratory pressure is applied by an external silicone collar worn around the anterior neck where it provides negative pressure to open the airway by pulling away the soft tissue structures.…”

“…Several types of machines prevent obstructive events by keeping the airway open (Table 2). [70][71][72][73][74][75] CPAP is the mainstay CPAP is a fi rst-line therapy for moderate or severe obstructive sleep apnea and for mild obstructive sleep apnea associated with comorbidities or cardiovascular risk factors. CPAP machines apply a positive pressure column of air to stent the upper airway and reduce the AHI, often to normal.…”

Sleep Medicine

“…A clinical trial using the device showed it to be safe and well tolerated and resulted in clinically significant improvements in sleep quality, AHI, degree of overnight desaturation, and daytime sleepiness but only in approximately 40% of the patients studied (Colrain et al 2013). A recent systematic review on the effectiveness of OPT in patients with OSA reported that the success rate of OPT varied between 25% and 37% (when defining success as at least a 50% reduction from baseline AHI and the post-OPT treatment residual AHI less than or equal to 10) (Nigam et al 2016). A meta-analysis of these data (on a total of 140 patients) concluded that OPT provided a 43% reduction in AHI but that severity of OSA could not be used to identify those who would most benefit from the therapy (Camacho et al 2016).…”