“…Pregnancy is perceived as a miracle. Many women feel an inner glow and bond to the growing fetus [1]. Glucose intolerance, which is first diagnosed during pregnancy is defined as gestational diabetes [2].…”
Background: Gestational diabetes [GDM] is one of the most common metabolic disorders associated with many adverse maternal and fetal complications including cardiovascular events. This study aimed to evaluate the function of the autonomic nervous system by heart rate variability [HRV] between pregnant women with GDM and healthy pregnant women. Methods: The study was a case-control observational study on 50 pregnant women with GDM and 51 healthy pregnant women. They were assigned to the study at 32-36 weeks of gestational age. Demographic and past medical history and lab findings were gathered. HRV was assessed by a time-domain analysis of 24-hour cardiac Holter monitoring including SDNN-SDANN-rMSSD and pNN50 variables.
Results:The mean age of the participants was 28.69 [± 5.5]. Data analysis showed no significant difference in the age [p-value: 0.10], maternal hypothyroidism [p-value: 0.2], and PCO [p-value: 1/000] between two groups. There was no significant difference between SDNN [p-value: 0.21], SDANN [pvalue: 0.11], and rMSSD [p-value: 0.87] between two groups. pNN50 in GDM group decreased significantly [P-value = 0.0001]. Conclusion: A significant decrease in the pNN50 index in GDM group may be a marker of autonomic dysfunction. Reduced pNN50 could be explained by decreasing parasympathetic activity and sympathetic overcome in pregnancy, especially in pregnancy associated with diabetes, leading to instability of the autonomic nervous system.
“…Pregnancy is perceived as a miracle. Many women feel an inner glow and bond to the growing fetus [1]. Glucose intolerance, which is first diagnosed during pregnancy is defined as gestational diabetes [2].…”
Background: Gestational diabetes [GDM] is one of the most common metabolic disorders associated with many adverse maternal and fetal complications including cardiovascular events. This study aimed to evaluate the function of the autonomic nervous system by heart rate variability [HRV] between pregnant women with GDM and healthy pregnant women. Methods: The study was a case-control observational study on 50 pregnant women with GDM and 51 healthy pregnant women. They were assigned to the study at 32-36 weeks of gestational age. Demographic and past medical history and lab findings were gathered. HRV was assessed by a time-domain analysis of 24-hour cardiac Holter monitoring including SDNN-SDANN-rMSSD and pNN50 variables.
Results:The mean age of the participants was 28.69 [± 5.5]. Data analysis showed no significant difference in the age [p-value: 0.10], maternal hypothyroidism [p-value: 0.2], and PCO [p-value: 1/000] between two groups. There was no significant difference between SDNN [p-value: 0.21], SDANN [pvalue: 0.11], and rMSSD [p-value: 0.87] between two groups. pNN50 in GDM group decreased significantly [P-value = 0.0001]. Conclusion: A significant decrease in the pNN50 index in GDM group may be a marker of autonomic dysfunction. Reduced pNN50 could be explained by decreasing parasympathetic activity and sympathetic overcome in pregnancy, especially in pregnancy associated with diabetes, leading to instability of the autonomic nervous system.
Introduction: Gestational diabetes mellitus (GDM) is one of the most common medical problems occurred during pregnancy. GDM increase the chance for developing type 2 diabetes meletus by seven times. The overall prevalence of GDM in pregnancy is 1-14% according to the American Diabetes Association. Material and Methods: a self-administered questionnaire was used to collect data. The information was collected from pregnant women with gestational DM to assess some maternal risk factors and compare blood glucose level according to different treatment types for GDM. Results: The present study reported that (40.38%) of GDM patients have advanced age (≥35 yrs.). First pregnancy was a risk factors for GDM and it was reported by (9.62%). History of HT and GDM during prior pregnancies were reported by (11.54%) and (% 34.62) respectively. Hypertension or preeclampsia in the current pregnancy was reported by (3.85%). Positive family history of diabetes was associated with (26.92%) GDM patients. All Patients of the present study reported no previous PCOS and smoking history. Also in this study, 44 patients out of 52 GDM patients use medications to control the glucose intolerance, while other patients control it by diet. There were no statistical differences found between treatment groups in term of blood glucose control. Conclusion: Age, history of GDM in the previous pregnancies and family history of diabetes mellitus were identifiable as a risk factors for GDM and their effect were significant in this study while the effect of other risk factors were non-significant. No statistical differences found between treatment groups in term of blood glucose level control and no group achieved the glycemic target.
Gestational Diabetes Mellitus is a disorder of carbohydrate tolerance that results in increased blood sugar levels and was first recognised during the second and third trimesters of pregnancy. It is a health problem that has a direct impact on the health of the mother and fetus. The purpose of this study was to analyse the effect of jackfruit (Artocarpus heterophyllus Lam.) Seed Ethanol Extract on reducing Blood Sugar Levels and Inflammation in Wistar Albino Rats with Gestational Diabetes Mellitus induced by Streptozotocin. This study used a laboratory experimental research design with a post-test only control group design on Wistar Albino Rats with Gestational Diabetes Mellitus. The sample was obtained by the simple random sampling method. The results showed that the lowest spectrophotometer KGD level was in group C given Streptozotocin 45mg/kg BW + Metformin 45mg/kg BW with a p value of 0.003, which means there was a significant difference between groups and the lowest Interleukin-6 level. In group C, they were given Streptozotocin 45mg/kg BW + Metformin 45mg/kg BW with a p value of 0.511, meaning there was no significant difference between groups. Jackfruit seed ethanol extract functions as a lowering of blood sugar levels and an anti-inflammatory.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.