Effectiveness of norfloxacin and ofloxacin for treatment of gonorrhoea and decrease of in vitro susceptibility to quinolones over time in Rwanda.

Bogaerts, J.; Tello, W Martinez; Akingeneye, J.; Mukantabana, V.; Dyck, E Van; Piot, Peter

doi:10.1136/sti.69.3.196

Cited by 31 publications

(19 citation statements)

References 17 publications

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“…A high prevalence of plasmid-mediated high-level or chromosomally mediated low-level resistance to penicillin or tetracycline in Southeast Asia (5-7, 13, 14) and African countries (2,11,23) has been reported.…”

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confidence: 99%

Emergence of in vitro resistance to fluoroquinolones in Neisseria gonorrhoeae isolated in Japan

Tanaka

Matsumoto

Kobayashi

et al. 1995

Antimicrob Agents Chemother

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To investigate emerging fluoroquinolone resistance in Neisseria gonorrhoeae isolated in Japan, we compared the in vitro antimicrobial susceptibilities of 79 gonococcal isolates from 1992 through 1993 to 14 fluoroquinolones and 14 other antibiotics with those of 27 isolates from between 1981 and 1984. The MICs at which 90% of the isolates were inhibited by nine fluoroquinolones, including norfloxacin, enoxacin, ofloxacin, ciprofloxacin, tosufloxacin, lomefloxacin, fleroxacin, levofloxacin, and sparfloxacin, for isolates from 1992 to 1993 were 8-or 16-fold higher than those for isolates from 1981 to 1984. Furthermore, the MICs at which 90% of the isolates were inhibited by five fluoroquinolones, including OPC-17116, T-3761, DU-6859a, AM-1155, and Q-35, that have recently been synthesized but have not yet been introduced for clinical use in Japan for isolates from 1992 to 1993 were also 2-to 16-fold higher than those for isolates from 1981 to 1984. The gonococcal isolates from 1992 to 1993 showed no significant decreases in susceptibility to ␤-lactams, tetracyclines, macrolides, and spectinomycin, compared with those for isolates from 1981 to 1984. Our data indicate that the incidence of gonococcal strains with decreased susceptibilities to fluoroquinolones is increasing in Japan.

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mentioning

confidence: 99%

Emergence of in vitro resistance to fluoroquinolones in Neisseria gonorrhoeae isolated in Japan

Tanaka

Matsumoto

Kobayashi

et al. 1995

Antimicrob Agents Chemother

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“…Resistance to penicillin and tetracycline was found increased considerably in 1989. The study concluded that antimicrobial susceptibility to the fluoroquinolones may also decrease rapidly [6]. A study from Japan revealed a rapid decrease in the susceptibility to nOrfloxacin [7].…”

Section: Discussionmentioning

confidence: 97%

Multidrug Resistance in Neisseria Gonorrhoeae

Rb¹

1998

Medical Journal Armed Forces India

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“…In Rwanda, both products were exclusively used for the treatment of gonorrhoea at the CMS clinic of Bilyogo during 1985-9 and were not available elsewhere in the country. 8 However, the widespread use of nalidixic acid (which is chemically related to the fluoroquinolones) for the treatment of dysentery caused by a multiresistant Shigella dysenteriae type 1 strain during 1981-8, may have contributed to this phenomenon. The emergence of high level resistance to tetracycline was related to the presence of the transferable tetM determinant coding for resistance to tetracycline.…”

Section: Discussionmentioning

confidence: 99%

“…Trends of antimicrobial resistance obtained previously in the same setting have been published in other papers. [5][6][7][8] In the present paper we analyse the antimicrobial susceptibility patterns and auxotype/serovar distribution of N gonorrhoeae in Kigali during 1985-93.…”

Section: Introductionmentioning

confidence: 99%

Auxotypes, serovars, and trends of antimicrobial resistance of Neisseria gonorrhoeae in Kigali, Rwanda (1985-93)

Bogaerts

Dyck

Mukantabana

et al. 1998

Sexually Transmitted Infections

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Objective: To investigate the in vitro antimicrobial susceptibility and the auxotype/serovar distribution of Neisseria gonorrhoeae in Kigali, Rwanda, during 1985-93. Methods: As part of a monitoring programme the in vitro susceptibility of 1604 isolates of N gonorrhoeae was determined by agar dilution. Auxo-and serotyping was performed on 1350 and 1313 isolates respectively. Results: The prevalence of penicillinase producing N gonorrhoeae (PPNG) remained stable at a rate of 39% during 1985-91 and increased to 61% in 1992-3. Chromosomal resistance to penicillin was common among non-PPNG and resistance to thiamphenicol and tetracycline was common among both PPNG and non-PPNG. High level, plasmid mediated resistance to tetracycline (TRNG) was observed for the first time at the end of 1989 and increased from 2% of the isolates in 1990 to 50% by 1993. A trend for increasing resistance to norfloxacin and ofloxacin was observed during 1985-90 but disappeared in 1991-93. Five isolates with high level resistance to norfloxacin (MIC 2 mg/l) were observed in 1990. Resistance to trimethoprimsulphamethoxazole (TMP-SMZ) emerged at the end of 1990 and was observed among 10% of the isolates during 1991-3. All strains remained susceptible to ofloxacin, ciprofloxacin, spectinomycin, and ceftriaxone. Overall, 75% of the isolates were prototrophic or required proline for their growth and 62% belonged to serovars IA-6 and IB-1. The prevalence of serovar IB-4 increased strongly during the last 3 years of the study. Conclusion: Resistance to penicillin, thiamphenicol, and tetracycline was common in N gonorrhoeae during 1985-1993. The rapid spread of TRNG after 1989 and the steep increase of PPNG during 1992-3 were the most striking facts of the study period. The auxotype and serovar distribution was comparable with findings from other African countries. (Sex Transm Inf 1998;74:205-209)

show abstract

Effectiveness of norfloxacin and ofloxacin for treatment of gonorrhoea and decrease of in vitro susceptibility to quinolones over time in Rwanda.

Cited by 31 publications

References 17 publications

Emergence of in vitro resistance to fluoroquinolones in Neisseria gonorrhoeae isolated in Japan

Emergence of in vitro resistance to fluoroquinolones in Neisseria gonorrhoeae isolated in Japan

Multidrug Resistance in Neisseria Gonorrhoeae

Auxotypes, serovars, and trends of antimicrobial resistance of Neisseria gonorrhoeae in Kigali, Rwanda (1985-93)

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