Effectiveness of non-steroidal anti-inflammatory drugs among patients with primary hypertrophic osteoarthropathy: A systematic review

Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial

“…As with other rare diseases, evidence-based treatment options for PHO are limited due to the small number of patients. Before the discovery of its underlying causes, treatments were mostly focused on alleviation of symptoms, including nonsteroidal antiinflammatory drugs (NSAIDs), pamidronate and tamoxifen citrate to relieve painful osteoarthropathy [9], [10], [11], [12], botulinum toxin type A injection and plastic surgery to improve cosmetic appearance [13] and arthroscopic synovectomy and radiosynoviorthesis for the management of recurrent arthritis [14]. However, given the knowledge that PGE2 may play an important role in the pathogenesis of PHO, cyclooxygenase (COX) inhibition may serve as a potential therapeutic option [15].…”

Coincidence of pachydermoperiostosis and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, a causal or casual association?

“…Drugs commonly used to relieve painful osteoarthropathy include salicylic acid, bisphosphonates, non‐steroidal anti‐inflammatory drugs (NSAIDs), glucocorticoids and colchicine. In addition, tamoxifen has been reported to be effective for refractory arthralgia which cannot be alleviated by NSAIDs 14 . Given the knowledge that PGE2 plays a major role in pathogenesis of PDP, we prescribed etoricoxib, a cyclo‐oxygenase‐2 inhibitor, which can suppress the biosynthesis of PGE2 in inflammatory and neoplastic disorders 14 .…”

“…In addition, tamoxifen has been reported to be effective for refractory arthralgia which cannot be alleviated by NSAIDs 14 . Given the knowledge that PGE2 plays a major role in pathogenesis of PDP, we prescribed etoricoxib, a cyclo‐oxygenase‐2 inhibitor, which can suppress the biosynthesis of PGE2 in inflammatory and neoplastic disorders 14 . As for acne conglobate, tetracyclines, such as minocycline, are considered first‐line therapy in patients with moderate‐to‐severe inflammatory or noninflammatory acne.…”

Primary hypertrophic osteoarthropathy

“…Поскольку специфического лечения не существует, применяют симптоматические средства, часто анальгетики. Результаты использования нестероидных противовоспалительных препаратов противоречивы, вместе с тем известно, что они уменьшают признаки воспаления [33]. Положительных результатов в лечении артралгий и синовиальных выпотов достигают при использовании эторикоксиба [15].…”

“…Для контроля симптомов изредка используют бисфосфонаты, снижающие уровень СЭФР и оказывающие антирезорбтивный эффект, уменьшающие распространенность периостоза. Глюкокортикоиды и колхицин применяют с целью уменьшения болейвозникающих при субпериостальном формировании «муфт», за счет уменьшения отека окружащих кости тканей [33]. При рефрактерном артрите отмечают уменьшение боли при применении моноклональных антител к фактору некроза опухоли (ФНО)α (инфликсимаб) ингибиторов СЭФР (гефетиниб, ингибитор тирозинкиназы EDFR), тамоксифена [34,35].…”