Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder

Kern, Janet K.; Miller, Van S.; Cauller, Lawrence J.; Kendall, Roger A.; Mehta, Jyutika; Dodd, Mary

doi:10.2310/7010.2001.17515

Cited by 30 publications

(29 citation statements)

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“…Two double-blind, placebo-controlled studies on dimethylglycine (a methyl donor with potential activity at NMDA receptors) showed no treatment effects on Vineland Adaptive Scores, Aberrant Behavior Checklist, or Children's Psychiatric Rating Scale scores. 130,131 Manipulative and body-based practices Chiropractic-inconclusive safety, inconclusive efficacy: Discourage.…”

Section: Biologically Based Practicesmentioning

confidence: 99%

Complementary and Alternative Medicine in Autism: An Evidence-Based Approach to Negotiating Safe and Efficacious Interventions with Families

2010

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Summary: This review focuses on helping clinicians identify resources and develop strategies they may use to effectively negotiate safe and effective use of complementary and alternative medicine (CAM) treatments with families of children with autism spectrum disorders (ASD), as well as other neurodevelopmental disorders. Since new types of CAM continue to be introduced into the autism community, emphasis is placed on providing clinicians with tools to help families negotiate the myriad of available treatments and make decisions based on current safety and efficacy data, while remaining mindful of the reasons families may be considering these treatments.We familiarize readers with high-quality, evidence-based resources that providers and families may use to ascertain current information about specific types of CAM, verify the content of biologically-based treatments, identify ongoing CAM research and obtain toolkits designed to help healthcare providers raise the topic of CAM usage and facilitate disclosure and discussion of CAM use with patients and their families. Key Words: Complementary and alternative medicine, autism, integrative medicine, gluten-free casein-free diet, melatonin, chelation, hyperbaric oxygen treatment, evidence-based medicine.

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Section: Biologically Based Practicesmentioning

confidence: 99%

Complementary and Alternative Medicine in Autism: An Evidence-Based Approach to Negotiating Safe and Efficacious Interventions with Families

2010

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“…The Vineland was used in two autism pharmacological studies, but the results did not show changes with the agents assessed. 10,37 The Vineland is under revision and, according to the publisher's website, the Vineland-II is expected to be available in 2005 (http://www.agsnet.com/assessments/vineland2.asp).…”

Section: Adaptive Behaviormentioning

confidence: 99%

Outcome Measures for Clinical Drug Trials in Autism

Aman¹,

Novotny²,

Samango‐Sprouse³

et al. 2004

CNS spectr.

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This paper identifies instruments and measures that may be appropriate for randomized clinical trials in participants with autism spectrum disorders (ASDs HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript scale was recommended for all randomized clinical trials. At this point, however, there is no "perfect" choice of outcome measure for core features of autism, although we will discuss five measures of potential utility. Several communication instruments are recommended, based in part on suitability across the age range. In trials where the intention is to alter core features of ASDs, adaptive behavior scales are also worthy of consideration. Several "behavior complexes" common to ASDs are identified, and instruments are recommended for assessment of these. Given the prevalence of cognitive impairment in ASDs, it is important to assess any cognitive effects, although cognitive data from ASD randomized clinical trials, thus far, are minimal. Guidance from trials in related pharmacologic areas and behavioral pharmacology may be helpful. We recommend routine elicitation of side effects, height and weight, vital signs, and (in the case of antipsychotics) extrapyramidal side-effects assessment. It is often appropriate to include laboratory tests and assessments for continence and sleep pattern.

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“…In the DMG study by Kern et al (2001), a greater number of adverse effects occurred in the placebo group than in the group receiving DMG. In the DMG group, 1 subject experienced difficulty sleeping, another experienced increased aggressiveness and 2 were reported to have hyperactivity.…”

Section: Dimethylglycine (Dmg)mentioning

confidence: 99%

“…Although there are numerous anecdotal reports that DMG reduces autistic behaviours and improves speech, as summarised in Table 2, administration of low dose DMG demonstrated no statistically significant effect on autistic behaviours in two double-blind, placebocontrolled trials (n = 8 & 37) (Bolman &Richmond 1999;Kern et al 2001). Therefore, DMG for the treatment of autism would be assigned to category C of the Natural Standard Research Collaboration grading rationale, i.e.…”

Section: Dimethylglycine (Dmg)mentioning

confidence: 99%

Complementary Medicine Products Used in Autism - Evidence for Efficacy and Safety

Semple¹,

Hewton²,

Paterson³

et al. 2011

Autism Spectrum Disorders - From Genes to Environment

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Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder

Cited by 30 publications

References 0 publications

Complementary and Alternative Medicine in Autism: An Evidence-Based Approach to Negotiating Safe and Efficacious Interventions with Families

Complementary and Alternative Medicine in Autism: An Evidence-Based Approach to Negotiating Safe and Efficacious Interventions with Families

Outcome Measures for Clinical Drug Trials in Autism

Complementary Medicine Products Used in Autism - Evidence for Efficacy and Safety

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