Effectiveness of monepantel and levamisole to control gastrointestinal strongylid parasites of sheep

Ciuffa, A. Z.; Urzedo, Mylla Christhie Costa; Silva, Danilo Mundim; Pires, Bruno; Rezende, Laís Miguel; Brasão, Silvia Cassimiro; Macedo, Gilberto de Lima; Rosalinski-Moraes, Fernanda

doi:10.14393/bj-v33n3-33325

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…It is noteworthy that resistance to monepantel emerged in T. vitrinus, a species that had not previously, or concurrently been shown to be resistant to any other anthelmintic drug groups on the farm. Previously documented reports of monepantel resistance all involve nematode species that were resistant to multiple other drugs (Scott et al, 2013;Mederos et al, 2014;Sales and Love, 2016;Lamb et al, 2017;Ciuffa et al, 2017), or at least to macrocyclic lactones (Brom et al, 2015). In these cases, the rapid development of resistance to monepantel and poor efficacies achieved against resistant populations might suggest a shared resistance mechanism with one or more of the other drug classes.…”

Section: Discussionmentioning

confidence: 99%

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Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock

Hamer

Bartley

Jennings

et al. 2018

Veterinary Parasitology

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Monepantel resistance was diagnosed during routine monitoring of the effectiveness of a farm's roundworm control strategy. Weaned lambs had become ill thrifty and developed diarrhoea, despite the routine use of monepantel. This clinical presentation was caused by trichostrongylosis. The faecal egg count reduction was 76.7% (95% CI: 55.1-82.2%) following treatment with 2.5 mg/kg monepantel. Predominantly Trichostrongylus vitrinus along with small proportions of Oesophagostomum venulosum and Trichostrongylus vitrinus were identified by deep amplicon sequencing of pools of larvae recovered from pre and post monepantel treatment coprocultures and on postmortem examinations. The undifferentiated FECRT showed resistance to monepantel, but not to levamisole, ivermectin, or moxidectin. Examination of farm anthelmintic treatment and animal movement records suggested that treatments before movement onto silage aftermaths, putatively with low numbers of susceptible nematodes in refugia, may have placed a high selection pressure on monepantel resistance. Effective control of parasitic gastroenteritis using anthelmintic drugs is a prerequisite for sustainable sheep production. This case reiterates the need for care when combining anthelmintic treatments with movements to safe grazing, and the value of monitoring of anthelmintic efficacy as part of iterative planned animal health management.

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Section: Discussionmentioning

confidence: 99%

“…The level of resistance in H. contortus was shown to be high in the majority of these investigations, with efficacy ranging from less than 50% to as low as zero. There have also been two reports of monepantel resistance from Brazil, implicating T. colubriformis (Cintra et al, 2016) and Oesophagostomum species (Ciuffa et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock

Hamer

Bartley

Jennings

et al. 2018

Veterinary Parasitology

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“…No entanto, existe muito variação de resultados entre regiões brasileiras, pois delineamento similar ao presente estudo foi feito em Minas Gerais, e os autores não constataram ineficácia do levamizole aos helmintos gastrointestinais, assim como baixa eficácia do monepantel ao Oesophagostomum spp. foi verificado por Ciuffa et al (2017).…”

Section: Discussionunclassified

Monepantel e levamisol no controle de helmintos gastrointestinais em rebanhos ovinos no Oeste de Santa Catarina

Gebert¹,

Reis²,

Santos³

et al. 2019

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El objetivo de este estudio fue evaluar la eficacia del monepantel y levamisol sobre los helmintos gastrointestinales en rebaños ovinos del oeste de Santa Catarina. El estudio fue realizado en dos etapas. En la primera de ellas se seleccionaron cinco granjas y se formaron tres grupos (K, L y M) de 8 ovinos cada uno. En los animales del grupo K se administró monepantel (2,5 mg/kg), en los del grupo L, levamisol (5,0 mg/kg) y los animales del grupo M se utilizaron como control (no medicados). Las muestras de heces fueron recogidas el día 0 y 10 de experimento, analizadas por la técnica de McMaster com el objetivo de determinar el número de huevos por gramo de heces (HPG), seguido de la técnica de coprocultivo para la identificación de los parásitos. La segunda etapa del estudio fue desarrollada en una granjas, donde se formaron los mismos tres grupos descritos anteriormente con sus respectivos tratamientos, y cinco días después de la administración del antiparasitario se realizó el muestreo de heces de estos animales para la realización de las pruebas ecotoxicológicas, utilizando colémbolos (Folsomia candida) como marcador biológico. Para simular el uso de las heces de ovinos como abono orgánico, definimos las dosis 0; 2; 4; y 8 toneladas de heces por hectárea, así como las pruebas de supervivencia y reproducción de acuerdo con las metodologías ISO. Los animales que recibieron el tratamiento con monepantel tuvieron reducción de la carga parasitaria (P

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Therapeutic efficacy of triclabendazole in comparison to combination of triclabendazole and levamisole in sheep naturally infected with Fasciola sp.

et al. 2021

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Effectiveness of monepantel and levamisole to control gastrointestinal strongylid parasites of sheep

Cited by 4 publications

References 13 publications

Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock

Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock

Monepantel e levamisol no controle de helmintos gastrointestinais em rebanhos ovinos no Oeste de Santa Catarina

Therapeutic efficacy of triclabendazole in comparison to combination of triclabendazole and levamisole in sheep naturally infected with Fasciola sp.

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