Effectiveness of Mindfulness-Based Cognitive Therapy in reducing psychological distress and improving sleep in patients with Inflammatory Bowel Disease: study protocol for a multicentre randomised controlled trial (MindIBD).

Avest, Milou M ter; Velthoven, Annelieke S M van; Speckens, Anne E. M.; Dijkstra, Gerard; Dresler, Martin; Horjus, Carmen S.; Römkens, Tessa E H; Witteman, E. M.; Dop, Willemijn A. van; Bredero, Quirine M; Nissen, Loes H C; Huijbers, Marloes J.

doi:10.1186/s40359-023-01127-0

Cited by 4 publications

(3 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This supports the hypothesis that enhancing mindfulness may lead to improvements in quality of life among individuals with chronic inflammatory conditions and is consistent with earlier studies. [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Mindfulness, Gut–Brain Axis, and Health-Related Quality of Life: The Paradigm of IBD Patients

Christodoulou,

Mpali,

Dimitriadou

et al. 2024

Healthcare

View full text Add to dashboard Cite

Health-related quality of life (HRQoL) is a comprehensive measure that evaluates an individual’s well-being across physical, mental, and social dimensions. Enhancing HRQoL, particularly in individuals with chronic conditions like inflammatory bowel diseases (IBD), necessitates a holistic approach. Mindfulness, a scientifically supported strategy for managing anxiety, has shown promise in improving both physical and mental health. Its benefits may be partly explained through its effects on the gut–brain axis (GBA), a bidirectional communication link between the gastrointestinal system and the central nervous system. By exploring the interplay between mindfulness and the GBA, this study aims to uncover how these elements collectively influence HRQoL in both healthy individuals and those with IBD, offering insights into potential therapeutic pathways. A cross-sectional investigation involved 338 adults, including 50 IBD patients, utilizing validated Greek scales for Mindfulness (MAAS-15), Mediterranean Diet (14-MEDAS), and HRQoL (EQ-5D-5L). The questionnaire gathered demographic, anthropometric, and lifestyle data. Among healthy participants, EQ-5D-5L showed a moderate correlation with the MAAS-15 scale (r = 0.389, p < 0.05) and a low correlation with 14-MEDAS (r = 0.131, p < 0.05). IBD patients exhibited significantly lower mean EQ-5D-5L scores than healthy individuals (0.75 vs. 0.85, p < 0.05). MAAS-15 demonstrated a robust correlation (r = 0.414, p < 0.001) with EQ-5D-5L in IBD patients. Elevated mindfulness levels emerged as predictive factors for higher HRQoL in IBD patients (OR: 1.101, 95% CI: 1.008, 1.202, p < 0.05, compared to low mindfulness). In summary, factors influencing the GBA, including mindfulness and the Mediterranean diet, exhibit positive associations with HRQoL. Increased mindfulness levels predict better HRQoL in IBD patients, emphasizing the potential for clinical trials to validate these cross-sectional study findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Mindfulness, Gut–Brain Axis, and Health-Related Quality of Life: The Paradigm of IBD Patients

Christodoulou,

Mpali,

Dimitriadou

et al. 2024

Healthcare

View full text Add to dashboard Cite

show abstract

“…The HADS is a 14-item self-report questionnaire, which has been validated as a reliable, consistent instrument in people with PD [ 24 ]. Previously, the HADS has been used as primary outcome measure in the largest MBI-RCT in PD to date [ 13 ], and RCTs investigating the effects of MBCT in other somatic illnesses have implemented the HADS as primary outcome as well [ 25 , 26 ]. Good psychometric properties of the Dutch HADS-total have been demonstrated in non-PD samples (Cronbach’s α = 0.82–0.90; [ 27 ]).…”

Section: Methods: Participants Interventions Randomization Procedures...mentioning

confidence: 99%

Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson’s disease

van der Heide,

Goltz,

de Vries

et al. 2024

BMC Neurol

View full text Add to dashboard Cite

Background People with Parkinson’s disease (PD) are very sensitive to the effects of stress. The prevalence of stress-related neuropsychiatric symptoms is high, and acute stress worsens motor symptoms. Animal studies suggest that chronic stress may accelerate disease progression, but evidence for this in humans is lacking. Mindfulness-based interventions (MBIs) train participants to focus on the present moment, on purpose and without judgement. Previous studies suggest that MBIs may alleviate stress and reduce depression and anxiety in PD. We aim to demonstrate the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) as a non-pharmacologic treatment strategy for neuropsychiatric (and motor) symptoms in PD, and to identify the mechanisms underlying stress and stress reduction in PD. Methods In a prospective randomized controlled trial (RCT), we investigate whether 8 weeks of MBCT, as compared to care as usual, can reduce symptoms of anxiety and depression in people with PD. We aim to include 124 PD patients, who experience mild-moderate symptoms of anxiety and depression, are eligible for magnetic resonance imaging (MRI) and naïve to mindfulness, and who have a disease duration ≤ 10 years. Every participant is followed for 12 months. Clinical and biochemical assessments take place at baseline (T0), after 2 months (T1), and after 12 months (T2); MRI assessments take place at T0 and T2. Our primary outcome is the total score on the Hospital Anxiety and Depression Scale (HADS) at T1, while correcting for the HADS score at T0, age, and gender. Beyond testing the effects of MBCT on symptoms of anxiety and depression in PD, we explore whether MBCT: (1) has an effect on motor symptom severity, (2) influences cerebral and biochemical markers of stress, and (3) leads to a change in biomarkers of PD progression. Discussion MIND-PD is one of the first RCTs with a 1-year follow-up to investigate the effects of MBCT on symptoms of anxiety and depression in PD, and to explore possible mechanisms underlying stress and stress reduction in PD. Insight into these mechanisms can pave the way to new treatment methods in the future. Trial registration ClinicalTrials.gov, NCT05779137. Registered on 12 January 2023.

show abstract

“…Recently, several research groups started to perform home studies with wearable EEG systems (e.g., Debellemaniere et al, 2018; Esfahani, Weber, et al, 2023; Healthy Brain Study consortium et al, 2021; Lustenberger et al, 2022; Talamini et al, in preparation; Ter Avest et al, 2023; Xi et al, 2023). However, the majority of home studies, including the aforementioned ones, still recruit participants using conventional methods.…”

Section: Citizen Neuroscience: Outlookmentioning

confidence: 99%

Citizen neuroscience: Wearable technology and open software to study the human brain in its natural habitat

Jafarzadeh Esfahani,

Sikder,

ter Horst

et al. 2024

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

Citizen science allows the public to participate in various stages of scientific research, including study design, data acquisition, and data analysis. Citizen science has a long history in several fields of the natural sciences, and with recent developments in wearable technology, neuroscience has also become more accessible to citizen scientists. This development was largely driven by the influx of minimal sensing systems in the consumer market, allowing more do‐it‐yourself (DIY) and quantified‐self (QS) investigations of the human brain. While most subfields of neuroscience require sophisticated monitoring devices and laboratories, the study of sleep characteristics can be performed at home with relevant noninvasive consumer devices. The strong influence of sleep quality on waking life and the accessibility of devices to measure sleep are two primary reasons citizen scientists have widely embraced sleep research. Their involvement has evolved from solely contributing to data collection to engaging in more collaborative or autonomous approaches, such as instigating ideas, formulating research inquiries, designing research protocols and methodology, acting upon their findings, and disseminating results. In this article, we introduce the emerging field of citizen neuroscience, illustrating examples of such projects in sleep research. We then provide overviews of the wearable technologies for tracking human neurophysiology and various open‐source software used to analyse them. Finally, we discuss the opportunities and challenges in citizen neuroscience projects and suggest how to improve the study of the human brain outside the laboratory.

show abstract

Effectiveness of Mindfulness-Based Cognitive Therapy in reducing psychological distress and improving sleep in patients with Inflammatory Bowel Disease: study protocol for a multicentre randomised controlled trial (MindIBD).

Cited by 4 publications

References 70 publications

Mindfulness, Gut–Brain Axis, and Health-Related Quality of Life: The Paradigm of IBD Patients

Mindfulness, Gut–Brain Axis, and Health-Related Quality of Life: The Paradigm of IBD Patients

Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson’s disease

Citizen neuroscience: Wearable technology and open software to study the human brain in its natural habitat

Contact Info

Product

Resources

About