Effectiveness of low-volume split-dose versus same-day morning polyethylene glycol regimen for adequacy of bowel preparation in patients undergoing colonoscopy: A single-blinded randomized controlled trial

Anudeep, K Venkata; Mohan, Pazhanivel; Selvan, K Senthamizh; Chellan, Deepak; Hamide, Abdoul

doi:10.1007/s12664-021-01228-x

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…In contrast Avolas et al & Bucci et al showed no significant difference in tolerability & willingness to repeat the same procedure between both regimes. 5 The strengths of this study are a large sample size, multi centre study and use of a standardized BBPS for colonscopy. The limitation of the study is that patients who had undergone bowel surgery were excluded; hence, the outcome of this study cannot be applied for all colonoscopies.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Same Day Polyethylene Glycol Regimen Vs Split Dose Polyethylene Glycol Regimen for Colonoscopy

Amjad¹,

Khan²,

Qamar³

et al. 2022

PJMHS

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Colonoscopy is a procedure which depends upon the quality of bowel preparation. Polyethylene glycol(PEG) is commonly used laxative for bowel preparation .The method of PEG administration affects the quality of bowel preparation. We designed this single-blinded randomized controlled trial to evaluate same day PEG regime vs split dose PEG regime in patients undergoing colonoscopy. METHOD: Total of 156 patients taken for the examination. They were divided randomly in two groups A & B. The patients in the group A (same day group) took 2 L of PEG between 6:00 AM and 8:00 AM on the same day of colonoscopy. The patients in the other group B ( split dose group ) took 1L of PEG between 6:00 PM and 8:00 PM on the preceding day and another liter between 6:00 AM and 8:00 AM on the day of colonoscopy. These patients had to stay in hospital for about 24 hours.The accuracy of preparation was assessed on Boston Bowel Preparation Scale (BBPS). A sum total of ≤ 5 points shows poor bowel preparation & ≥ 8 shows very good bowel preparation. Side effects were recorded by asking symptoms of nausea ,vomiting ,abdominal pain & bloating. Results: In same day dose group, 62 patients were having BPPS preparation score of >8 . While in second split dose group 64 patients were having BPPS preparation score >8. Chi square test revealed that there was no significant difference in BPPS score between both groups. However there was significant difference in patient satisfaction and willingness to repeat the same procedure between both groups. . Group A same dose regime were more satisfied & willing to repeat the procedure. They reported less interference in their sleep . Conclusion: Same- day morning PEG regime should be used which is more easy & tolerable for our patients population and its efficacy is same as other regimes for adequate bowel preparation.

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Section: Resultsmentioning

confidence: 99%

“…The timing of administration of Polyethylene glycol (PEG) effects the quality of bowel preparation. 5 The colon becomes increasingly filled with fluid or debris 6 if there is a long time between the administration of PEG and colonoscopy. 7 Hence same day PEG regime became more practical than currently recommended split dose PEG regime.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Same Day Polyethylene Glycol Regimen Vs Split Dose Polyethylene Glycol Regimen for Colonoscopy

Amjad¹,

Khan²,

Qamar³

et al. 2022

PJMHS

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Editorial commentary on the Indian Journal of Gastroenterology—May–June 2022

Limdi

2022

Indian J Gastroenterol

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Ratio of aspartate aminotransferase to alanine aminotransferase and alkaline phosphatase to total bilirubin in Wilsonian acute liver failure in children Acute liver failure (ALF) secondary to Wilson's disease (WD) is invariably fatal without emergency liver transplantation, and requires a prompt diagnosis [1]. Although reduced ceruloplasmin and elevated copper levels support a diagnosis of WD, they are less reliable in a fulminant setting [1]. Laboratory findings associated with fulminant WD include Coombs negative hemolytic anemia, low serum uric acid levels, low serum alkaline phosphatase (ALP) activity and increased aspartate amino transferase (AST):alanine amino transferase (ALT) ratios [2].Yasmin and colleagues from Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, report on a series of 60 children with ALF, of whom 40 had WDassociated ALF (WALF) [3]. The median AST/ALT ratio was higher in WALF than in non-WALF patients with sensitivity and specificity of 70% and 95% and a positive and negative predictive value of 96.5% and 61.3%, respectively. At a cut-off value of ≥1.85, AST/ALT ratio had a sensitivity of 77.5% and specificity of 95%. An ALP/total bilirubin ratio <4 had sensitivity and specificity of 32.5% and 100% and a positive and negative predictive value of 100% and 42.5%, respectively. The authors suggest that using these routinely available tests, patients with fulminant WD may be identified promptly, enabling emergency listing for liver transplantation for this rare but near uniformly fatal disorder.

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Effectiveness of low-volume split-dose versus same-day morning polyethylene glycol regimen for adequacy of bowel preparation in patients undergoing colonoscopy: A single-blinded randomized controlled trial

Cited by 2 publications

References 33 publications

Comparison of Same Day Polyethylene Glycol Regimen Vs Split Dose Polyethylene Glycol Regimen for Colonoscopy

Comparison of Same Day Polyethylene Glycol Regimen Vs Split Dose Polyethylene Glycol Regimen for Colonoscopy

Editorial commentary on the Indian Journal of Gastroenterology—May–June 2022

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