Effectiveness of Low-Dose Crystalline Nicotinic Acid in Men With Low High-Density Lipoprotein Cholesterol Levels

Martín-Jadraque, Raquel; Tatò, Federico; Mostaza, J.M.; Vega, Gloria Lena; Grundy, Scott M.

doi:10.1001/archinte.1996.00040041081006

Cited by 35 publications

(2 citation statements)

References 41 publications

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“…Studies in which ASA was used to reduce flushing reported discontinuation rates due to flushing that were much lower than those commonly cited for NA: less than 8% in the studies reviewed here, compared with up to 40% in other published studies using older formulations of NA (Table 2)(59–64).…”

Section: Discussionmentioning

confidence: 52%

Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment

Oberwittler

Baccara‐Dinet

2006

International Journal of Clinical Practice

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Nicotinic acid (NA) is highly effective and widely used in the management of dyslipidaemia. For many patients, the side effect of flushing of the face and upper body leads to discontinuation. Flushing with NA is mediated by prostaglandins, and as acetyl salicylic acid (ASA, 'aspirin') is a highly effective inhibitor of prostaglandin synthesis, there is a rationale for its use to prevent or reduce the severity of NA-related flushing. This literature survey identified four studies specifically exploring the utility of ASA in preventing NA-related flushing in healthy volunteers. Twenty-three NA studies, where ASA was mandatory or optional within the protocol, and four studies, where background ASA therapy was reported in most participants, were also identified. Although the incidence of flushing in studies using ASA was often high, discontinuation rates due to flushing were low (mean 7.7%). This figure compares favourably with discontinuation rates with NA commonly reported in the literature (up to approximately 40%). There is good supportive evidence for the use of ASA in reducing the severity of NA-related flushing.

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Section: Discussionmentioning

confidence: 52%

Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment

Oberwittler

Baccara‐Dinet

2006

International Journal of Clinical Practice

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“…The magnitude of difference in the lipid profile among persons 60 years of age or older was clinically meaningful. For example, the 21% higher HDL cholesterol level associated with prednisone use is substantially better than the 8 -10% increase with statins shown in clinical trials (15) and similar to that observed with nicotinic acid (20%) (16). The clinical relevance was further supported by the result of our analysis using HDL cholesterol cut-offs that predict coronary artery disease (13) (e.g., the odds of having a normal HDL cholesterol level was 4.7 times higher among prednisone users than among nonusers).…”

Section: Discussionmentioning

confidence: 63%

Glucocorticoid use and serum lipid levels in US adults: The third national health and nutrition examination survey

Choi

Seeger²

2005

Arthritis Rheum

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Objective. It has been generally perceived that glucocorticoids adversely affect serum lipid levels, although results of prospective studies have suggested the contrary. In this study, we sought to examine the relationship between glucocorticoid use and lipid profiles in a nationally representative sample of subjects. Methods. Using data from 15,004 participants ages 20 years and older in The Third National Health and Nutrition Examination Survey (1988 -1994), we examined the relationship between glucocorticoid use and serum lipid profiles. Glucocorticoid use was determined from the household interview regarding prescription medication use. We used multivariate linear regression to adjust for age, sex, race or ethnicity, education, smoking status, body mass index, physical activity, alcohol consumption, energy fraction from protein and carbohydrates, and total energy intake. Results. Glucocorticoid use was associated with a higher serum high-density lipoprotein (HDL) cholesterol level and a lower ratio of total cholesterol-to-HDL cholesterol among subjects ages 60 years or older (multivariate difference 9.0 mg/dl [95% confidence interval (95% CI) 3.9, 14.1] and ؊0.6 mg/dl [95% CI ؊0.9, ؊0.3], respectively) but not among those younger than age 60 years (multivariate difference ؊1.

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New Perspectives on the Management of Low Levels of High-Density Lipoprotein Cholesterol

Harper¹,

Jacobson²

1999

Arch Intern Med

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A low serum high-density lipoprotein cholesterol (HDL-C) level is a potent predictor of coronary heart disease (CHD). It has been estimated that 11% of US men have isolated low HDL-C levels, and there is uncertainty regarding the management of these patients. A cause-and-effect relationship between low HDL-C levels and CHD is supported by epidemiological, animal, and human clinical studies. We reviewed the structure and function of HDL-C and its role in preventing atherosclerosis. We then suggested an approach to the patient with isolated low HDL-C that may be useful to the primary care physician. An algorithm was proposed for use in patients with existing CHD, while the decision to treat patients without CHD was based on their score on the Framingham Heart Study risk prediction chart.

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Effectiveness of Low-Dose Crystalline Nicotinic Acid in Men With Low High-Density Lipoprotein Cholesterol Levels

Cited by 35 publications

References 41 publications

Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment

Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment

Glucocorticoid use and serum lipid levels in US adults: The third national health and nutrition examination survey

New Perspectives on the Management of Low Levels of High-Density Lipoprotein Cholesterol

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