Effectiveness of liposomal system of delivery of hydrophobic antineoplastic thiosens photosensitizer

Abstract

The implementation of liposome delivery systems ensures the intravenous introduction of hydrophobic photosensitizers used in the treatment of tumors by the photodynamic therapy method with their preservation in a therapeutically effective nonaggregated form and high accumulation selectivity in the tumor. Phthalocyanines are one of the fastest growing classes of antineoplastic photosensitizers, most of which are hydrophobic compounds. In this study the authors have developed the unique composition and technology of preparing the lyophilized liposomal formulation of infrared photosensitizer: aluminum hydroxide tetra-3phenylthiophtalocyanine (Thiosens). At the stage of biological experiments on model mouse tumors, the preservation of high accumulation selectivity in the tumor (selectivity index is higher than 4) and antineoplastic effectiveness (inhibition of tumor growth is from 70 to 94%) were found during the transition from the previously studied model dosage form to the created lyophilized liposomal one. To estimate chemical and pharmaceutical criteria and the photodynamic efficiency of the photosensitizer on a number of transplanted mice tumor models in vivo, we have conducted a preclinical study which has demonstrated the stability of antitumor activity and quality consistency of the developed dosage form for one and a half years.

Topical Gadobutrol Application Causes Fluorescence Intensity Change in RFP-expressing Tumor-Bearing Mice

“…These methods provide a means for detecting of fluorescent signal in a living animal that reflects specific, mostly disease-related processes, such as the host immune response, inflammation, tumor growth or the presence of pathogens [1][2][3]. This method was successfully applied for in vivo studying of photosensitizers [4][5][6] or nanoparticles distribution in living animal [7,8], for studying of various pathological processes using specific targets labeled with different fluorescent probes [2,9]. In the case of epifluorescence imaging fluorophore molecules J of Biomedical Photonics & Eng 7 (2) 27 Mar 2021 © J-BPE 020301-2 located on the surface or very close to it provide major contribution to the total intensity of fluorescence (FI).…”

Plasmon-enhanced sensitization of singlet oxygen on silver island films

“…One of the important requirements for PCs for their practical use in PDT is their water solubility [31]. In this case, an important factor in the study is the interaction between colloidal metal NPs and PS molecules in solutions.…”

Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan

“…It has a maximum absorption at 717 ± 4 nm, and provides the possibility of intravenous administration of an innovative hydrophobic substance into the patient's body. Development of Lipophtalocyan conducted by a team of researchers from State scientific center "NIOPIK" and N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation [2].…”