Effectiveness of Lifestyle Modification in Polycystic Ovary Syndrome Patients with Obesity: A Systematic Review and Meta-Analysis

Abstract

(1) Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and endocrine disorders among women of reproductive age. Previous studies have employed lifestyle interventions to manage anovulatory infertility and endocrine disorders. However, the effect of lifestyle interventions on the metabolic index remains ambiguous; (2) Methods: Data were obtained through a systematic search of the Ovid-Medline, Ovid-EMBASE, and Cochrane Library databases. Two reviewers independently reviewed the literature in two stages. A consensus was achieved through discussions regarding the final selection of the literature; (3) Results: This study observed that the group that underwent lifestyle modifications displayed significant improvement in reproductive function compared to the control group. Combination therapy with diet and exercise resulted in improved fasting insulin levels, compared to monotherapy with diet or exercise. Moreover, moderate weight loss (a minimum of 5%) resulted in an improved metabolic index. The subgroup analysis revealed that the group that underwent lifestyle modifications had a significantly higher number of patients with improved menstrual cycles, compared to the control groups; (4) Conclusions: Lifestyle modification using combination therapy is a promising therapeutic approach that can be employed in the management of PCOS patients with obesity. This scenario warrants further studies with larger sample sizes to develop ideal treatment protocols.

Therapy of obesity in women with PCOS using GLP-1 analogues — benefits and limitations [Terapia otyłości u kobiet z PCOS przy zastosowaniu analogów GLP-1 — korzyści i ograniczenia]

“…In addition, moderate weight loss by a minimum of 5% of primary body weight was effective in improving fasting insulin levels that served as the metabolic index. The BMI and body weight of the intervention group were markedly lower than those of the controls [33]. Thus, it is important to recommend dietary interventions to reduce caloric in-REVIEW take as well as regular physical activity as the primary treatment for weight management in obese women with PCOS.…”

“…Ponadto umiarkowana redukcja masy ciała o co najmniej 5% pierwotnej masy ciała była skuteczna w obniżaniu stężenia insuliny na czczo, które służyło jako wskaźnik metaboliczny. Masa ciała i BMI w grupie, w której zastosowano badaną interwencję, były znacznie niższe niż w grupie kontrolnej [33]. Ważne jest więc, aby otyłym kobietom z PCOS zalecać interwencje dietetyczne w celu zmniejszenia spożycia kalorii, a także regularną aktywność fizyczną jako podstawowe leczenie nadwagi/otyłości.…”

Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis

“…Dietary intervention include calorie reduction or diet structure change (carbohydrate counting, fat counting, protein counting). 23 And exercise intervention include resistance or aerobic exercise. 23 Studies used single or multiple non-pharmacological intervention(s) will be considered.…”

“… 23 And exercise intervention include resistance or aerobic exercise. 23 Studies used single or multiple non-pharmacological intervention(s) will be considered.…”

“…Non-pharmacological interventions will be limited to lifestyle interventions (including dietary intervention, exercise intervention and behavioural intervention), acupuncture therapies and nutritional supplements. Dietary intervention include calorie reduction or diet structure change (carbohydrate counting, fat counting, protein counting) 23. And exercise intervention include resistance or aerobic exercise 23.…”