Effectiveness of licorice in preventing dental caries in children: A systematic review

Tharakan, Ann Polachirakal; Pawar, Madhura; Kale, Sonal

doi:10.4103/jisppd.jisppd_100_20

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Licorice has been studied extensively for its anticaries properties [ 49 , 74 , 94 , 95 , 109 , 130 , 131 , 132 , 133 , 134 , 135 ]. Phytochemical analysis of the roots of Glycyrrhiza uralensis verified the presence of pterocarpanes (glycyrrhizol A and glycyrrhizol B), along with four isoflavonoids [ 134 ].…”

Section: Discussionmentioning

confidence: 99%

Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention

Tzimas,

Antoniadou,

Varzakas

et al. 2024

CIMB

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There is a growing shift from the use of conventional pharmaceutical oral care products to the use of herbal extracts and traditional remedies in dental caries prevention. This is attributed to the potential environmental and health implications of contemporary oral products. This comprehensive review aims at the analysis of plant-derived compounds as preventive modalities in dental caries research. It focuses on data collected from 2019 until recently, trying to emphasize current trends in this topic. The research findings suggest that several plant-derived compounds, either aqueous or ethanolic, exhibit notable antibacterial effects against Streptococcus mutans and other bacteria related to dental caries, with some extracts demonstrating an efficacy comparable to that of chlorhexidine. Furthermore, in vivo studies using plant-derived compounds incorporated in food derivatives, such as lollipops, have shown promising results by significantly reducing Streptococcus mutans in high-risk caries children. In vitro studies on plant-derived compounds have revealed bactericidal and bacteriostatic activity against S. mutans, suggesting their potential use as dental caries preventive agents. Medicinal plants, plant-derived phytochemicals, essential oils, and other food compounds have exhibited promising antimicrobial activity against oral pathogens, either by their anti-adhesion activity, the inhibition of extracellular microbial enzymes, or their direct action on microbial species and acid production. However, further research is needed to assess their antimicrobial activity and to evaluate the cytotoxicity and safety profiles of these plant-derived compounds before their widespread clinical use can be recommended.

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Section: Discussionmentioning

confidence: 99%

Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention

Tzimas,

Antoniadou,

Varzakas

et al. 2024

CIMB

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“…Antimicrobial photodynamic therapy using Emodin-CH NPs has been reported to inhibit significantly biofilm formation and reduce the S. mutans virulence potency [ 43 ]. Incorporating antimicrobial agents in the form of edibles such as chewing gums and lollipops may be considered an attractive method for delivering anticaries effects, especially for children at higher risk of dental caries [ 32 ]. Therefore, we formulated the experimental lollipops containing CH-ZnO NPs.…”

Section: Discussionmentioning

confidence: 99%

“…Given the preference of patients, especially those at high risk of dental caries, for edible products, the incorporation of antibacterial agents into sugar-free candies and lollipops presents a practical means of reducing bacterial accumulation and adhesion, ultimately mitigating caries. This approach may be particularly beneficial in low and middle-income countries with high rates of childhood caries, often attributable to elevated sugar consumption [ 13 , 32 , 33 ]. Thus, our in vitro study is designed to formulate and characterize experimental lollipops containing CH-ZnO nanoparticles (CH-ZnO NPs) and investigate their antimicrobial effects on both planktonic and biofilm forms of S. mutans and L. acidophilus .…”

Section: Introductionmentioning

confidence: 99%

Formulation and antibacterial properties of lollipops containing of chitosan- zinc oxide nano particles on planktonic and biofilm forms of Streptococcus mutans and Lactobacillus acidophilus

Mohammadipour,

Tajzadeh,

Atashparvar

et al. 2023

BMC Oral Health

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This study aimed to formulate and characterize the experimental lollipops containing chitosan- zinc oxide nanoparticles (CH-ZnO NPs) and investigate their antimicrobial effects against some cariogenic bacteria. The CH-ZnO NPs were synthesized and characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) analysis, and Transmission electron microscope (TEM). Then, four groups were made, including lollipops coated with 2 and 4 ml of CH-ZnO NPs, 0.7 ml CH-ZnO NPs incorporated lollipops, and those with no CH-ZnO NPs. Their antibacterial effectiveness against Streptococcus mutans and Lactobacillus acidophilus was evaluated by direct contact test and tissue culture plate method in planktonic and biofilm phases, respectively. Chlorhexidine mouthrinse (CHX) was used as a positive control group. In the planktonic phase, the antibacterial properties of both groups coated with CH-ZnO NPs were comparable and significantly higher than incorporated ones. There was no significant difference between CHX and the lollipops coated with 4 ml of NPs against S. mutans and CHX and two coated groups against L. acidophilus. None of the experimental lollipops in the biofilm phase could reduce both bacteria counts. The experimental lollipops coated with 2 and 4 ml of CH-ZnO NPs could reveal favorable antimicrobial properties against two cariogenic bacteria in the planktonic phase.

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Do natural ingredients in a dentifrice contribute to prevention of plaque and gingivitis?

Valkenburg

Rosema

Hennequin-Hoenderdos

et al. 2021

Int J Dental Hygiene

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Objective: To test the effectiveness of a dentifrice containing the turmeric and licorice extract compared to a control for preventing plaque and gingivitis over a fourmonth period.Material and methods: Ninety (non-dental) participants with moderate gingival inflammation (≥ 40%) were selected. The triple blind study consisted of two phases, namely at first a 3-week pre-experimental phase of using an oxygenating and chlorhexidine (CHX) mouthrinse. Secondly, a 4-month experimental period in which participants were randomly assigned to a test or control group. All were instructed to brush their teeth twice daily for 2 minutes with their assigned dentifrice. Gingival bleeding (BI), plaque (PI) and gingivitis (GI) were assessed.Results: Eighty participants completed the protocol. At the first assessment in the pre-experimental phase, the mean scores of all indices showed no differences for the two groups. At the second session, the values of all three parameters had decreased significantly (p < 0.001). At the last session, the BI values were 0.52(0.25) for the test group and 0.56(0.25) for the control, the mean GI was 0.27(0.17) for the test group and 0.31(0.16) for the control, and for PI the scores were 1.89(0.46) for the test group and 1.98(0.43) for the control group. Statistical comparison of the scores for the two groups at each stage of the study showed no significant difference for any of the parameters. Conclusion:Within the limits of the current study design, dentifrice formulation and concentration of turmeric/licorice extracts, the results show that the adjuvant effect of the natural ingredients in the test dentifrice was not evident on clinical parameters of gingivitis and plaque.

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Effectiveness of licorice in preventing dental caries in children: A systematic review

Cited by 5 publications

References 19 publications

Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention

Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention

Formulation and antibacterial properties of lollipops containing of chitosan- zinc oxide nano particles on planktonic and biofilm forms of Streptococcus mutans and Lactobacillus acidophilus

Do natural ingredients in a dentifrice contribute to prevention of plaque and gingivitis?

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