Effectiveness of Levoamlodipine Maleate for Hypertension Compared with Amlodipine Besylate: a Pragmatic Comparative Effectiveness Study

Ma, Wei; Sun, Ning; Duan, Chongyang; Zhao, Lei; Hua, Qi; Sun, Yingxian; Dang, Anhong; Gao, Pingjin; Qü, Ping; Cui, Wei; Zhao, Luosha; Dong, Yugang; Cui, Lianqun; Qi, Xiaoyong; Xie, Jianhong; Li, Jun; Wu, Gang; Du, Xinping; Huo, Yong; Chen, Pingyan

doi:10.1007/s10557-020-07054-1

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…This was a multicenter, retrospective, and follow-up study. All hypertensive patients treated with levoamlodipine maleate or amlodipine besylate at 110 centers in 21 cities in China, came from a previous study ( 10 ), and met the standards of the Chinese Guidelines for Prevention and Treatment of Hypertension ( 4 ). All the patients received calcium channel blockers (CCBs) levamlodipine maleate or amlodipine besylate, and were followed up for further 24 months.…”

Section: Methodsmentioning

confidence: 99%

Association Between Heart Rate and Major Adverse Cardiovascular Events Among 9,991 Hypertentive Patients: A Multicenter Retrospective Follow-Up Study

Sun

Chen

et al. 2021

Front. Cardiovasc. Med.

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Objective: To assess the effect of heart rate at baseline on major adverse cardiovascular events (MACEs) among hypertensive patients in China.Methods: A multicenter retrospective study was conducted with a 24 month follow-up period. A total of 10,031 hypertensive patients treated with standard antihypertensive drugs were grouped according to their heart rate before treatment: <65 beats per min (bpm), 65–69 bpm, 70–74 bpm, 75–79 bpm, and ≥80 bpm. The occurrence of any of MACEs was as the endpoint event during the 24 month follow-up period. The effect of heart rate at baseline on MACEs was analyzed using univate and multivariable Cox proportional regression analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs). The restricted cubic spline (RCS) model was used to fit the Cox proportional harzard model with 5 knots at the 5th, 25th, 50th, 75th, and 95th percentiles of heart rate.Results: Totally 9,991 patients were finally enrolled with the mean systolic pressure (SBP)/diastolic pressure (DBP) of 130.59 ± 7.13/77.66 ± 5.99 mmHg at 24 month follow-up. The incidence of MACEs was 4.80% (n = 480). After adjustment for age, gender, baseline blood pressure, alcohol drinking, smoking, hyperlipidemia, diabetes, coronary heart disease, cerebrovascular disease and antihypertensive drug use, patients with heart rate <65 bpm (HR = 1.450, 95% CI: 1.098–1.915) and ≥80 bpm (HR = 1.391, 95% CI: 1.056–11.832) showed 0.45 fold and 0.391 fold increases of MACE risks, compared with patients with heart rate of 70–74 bpm. Furthermore, MACE risks were increased by 86.0% and 65.4% in men, and 59.3% and 69.0% in elderly patients aged ≥65 years at heart rate <65 bpm or ≥80 bpm, respectively. We also found a non-liner U-shaped correlation between heart rate and the occurrence of MACEs.Conclusions: Heart rate might be an independent risk factor for MACEs in hypertensive patients. An appropriate range of heart rate control may offer guidance to hypertension treatment.

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Section: Methodsmentioning

confidence: 99%

Association Between Heart Rate and Major Adverse Cardiovascular Events Among 9,991 Hypertentive Patients: A Multicenter Retrospective Follow-Up Study

Sun

Chen

et al. 2021

Front. Cardiovasc. Med.

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“…Além disso, ao se comparar o efeito e a segurança relacionados ao anlodipino (BCC mais usado devido à disponibilidade no SUS) e ao levanlodipino (BCC mais requisitado pelos participantes da pesquisa), evidencia-se leve superioridade do levanlodipino. Nesse sentido, o uso de levanlodipino, quando comparado ao anlodipino durante um período de 24 meses, demonstrou melhor controle da PA além de menos efeitos colaterais, especialmente o edema de membros inferiores (Ma et al, 2021).…”

Section: Comparação Da Disponibilidade De Anti-hipertensivos No Munic...unclassified

Perfil de prescrição de anti-hipertensivos na Atenção Básica do município de Araranguá

Júnior

Kyburz²,

Sousa³

et al. 2022

RSD

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A HAS é uma patologia de extrema recorrência na população brasileira e apresenta características que a tornam um importante fator de risco para o desenvolvimento de desfechos CV. Nesse contexto, o estudo do perfil de prescrição de medicamentos em uma determinada localidade pode identificar e avaliar variáveis importantes na qualidade prescritiva. Este estudo analisou o perfil de prescrição de anti-hipertensivos na AB do município de Araranguá, no estado de Santa Catarina, de acordo com a percepção dos prescritores. Foi realizado um estudo transversal, quantitativo, descritivo, por meio de uma entrevista semiestruturada, aplicada entre dezembro de 2021 e fevereiro de 2022. A população de estudo foram os médicos prescritores que atuavam na rede primária do município. Os resultados obtidos demonstraram que o perfil de médicos é formado, predominantemente, por profissionais jovens (<30 anos) e com pouca experiência clínica. As formas de atualização mais utilizadas pelos prescritores foram as diretrizes/consensos e os aplicativos/sites médicos. As classes de medicamentos anti- hipertensivos mais prescritas foram, em ordem: IECA, Diuréticos Tiazídicos e BRA. A maioria dos médicos concordou que o SUS disponibiliza os medicamentos necessários para o tratamento da HAS. Conclui-se que o perfil de prescrição de anti- hipertensivos da população de estudo apresenta determinada heterogeneidade, mas, de maneira geral, é congruente com as melhores evidências disponíveis para o tratamento da HAS.

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The Protective Effects of Mogroside V Against Neuronal Damages by Attenuating Mitochondrial Dysfunction via Upregulating Sirtuin3

Luo

Peng

et al. 2022

Mol Neurobiol

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Effectiveness of Levoamlodipine Maleate for Hypertension Compared with Amlodipine Besylate: a Pragmatic Comparative Effectiveness Study

Cited by 4 publications

References 28 publications

Association Between Heart Rate and Major Adverse Cardiovascular Events Among 9,991 Hypertentive Patients: A Multicenter Retrospective Follow-Up Study

Association Between Heart Rate and Major Adverse Cardiovascular Events Among 9,991 Hypertentive Patients: A Multicenter Retrospective Follow-Up Study

Perfil de prescrição de anti-hipertensivos na Atenção Básica do município de Araranguá

The Protective Effects of Mogroside V Against Neuronal Damages by Attenuating Mitochondrial Dysfunction via Upregulating Sirtuin3

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