Effectiveness of Lavendula stoechas essential oil in treatment of mild to moderate carpal tunnel syndrome: A randomized controlled trial

Eftekharsadat, Bina; Roomizadeh, Peyman; Torabi, Shervin; Heshmati-Afshar, Fariba; Jahanjoo, Fatemeh; Babaei-Ghazani, Arash

doi:10.1016/j.jht.2017.07.004

Cited by 15 publications

(11 citation statements)

References 36 publications

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“…Lastly, lavender ointment combined with a night splint did not yield any significant differences compared with the placebo groups [49]. Lavender ointment and placebo were instructed to be applied on their affected wrist in the morning and evening time for 40 days.…”

Section: Interventionmentioning

confidence: 99%

“…Three studies compared electrotherapy and a drug intervention [24,47,48] and two studies compared electrotherapy and manual therapy [23,30]. Two articles differed from these categories: one study analyzed the effectiveness of an alternative therapy (lavender ointment) [49] and the other one, a thermal agent (paraffin wax) [50]. Twelve studies had a control group [22,25,27,28,33,[41][42][43][44][45][46]; nine studies a placebo group [21,29,[37][38][39][40]42,48,49]; and thirteen studies an alternative treatment [23,24,26,27,30,32,[34][35][36][37]39,47,48].…”

Section: Interventionmentioning

confidence: 99%

“…Two articles differed from these categories: one study analyzed the effectiveness of an alternative therapy (lavender ointment) [49] and the other one, a thermal agent (paraffin wax) [50]. Twelve studies had a control group [22,25,27,28,33,[41][42][43][44][45][46]; nine studies a placebo group [21,29,[37][38][39][40]42,48,49]; and thirteen studies an alternative treatment [23,24,26,27,30,32,[34][35][36][37]39,47,48]. There were six articles having three or more groups [27,32,37,39,42,48].…”

Section: Interventionmentioning

confidence: 99%

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Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review

Hernández-Secorún

Montaña-Cortés

Hidalgo-García

et al. 2021

IJERPH

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(1) Background: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy in the upper extremity. Conservative treatment has been effective for mild and moderate idiopathic CTS. However, severe CTS and systemic conditions were an exclusion criterion from the studies. The aim of this study is to review the effectiveness of conservative treatment in patients with CTS regardless of the level of severity and the presence or not of systemic diseases in the last ten years. (2) Methods: Randomized controlled clinical trials that compared the effect of conservative treatment on the Boston questionnaire and pain were selected. PubMed, PEDro, Scopus, Cochrane, and Web of Science databases were used. PRISMA statement checklist was performed. (3) Results: 876 studies were recorded, 29 were selected. Pharmacology, Electrotherapy and Manual Therapy had benefits for CTS. Electrotherapy and manual therapy could be effective for severe CTS patients with a systemic condition in the short term, but there was a low percentage of these patients included in the studies. (4) Conclusion: Some pharmacological treatments, manual therapy and electrotherapy have shown benefits for handling CTS, although the most effective combination of techniques is unknown. It would be necessary to include patients with systemic conditions in the selection criteria for future studies.

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Section: Interventionmentioning

confidence: 99%

Section: Interventionmentioning

confidence: 99%

Section: Interventionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review

Hernández-Secorún

Montaña-Cortés

Hidalgo-García

et al. 2021

IJERPH

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“…Present results give the first description of the capability of LEO to ameliorate hyperalgesia in neuropathic pain conditions after a single oral administration. A recent clinical study reported the efficacy of topical application of the essential oil of L. stoechas , another plant from the genus Lavandula , on reducing pain intensity in mild to moderate carpal tunnel syndrome, the most common entrapment neuropathy of the upper extremity (Eftekharsadat et al., 2017), further supporting the hypothesis of a positive effect of lavender essential oils in neuropathic pain conditions.…”

Section: Discussionmentioning

confidence: 86%

Lavender (Lavandula angustifolia Mill.) Essential Oil Alleviates Neuropathic Pain in Mice With Spared Nerve Injury

et al. 2019

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Low treatment efficacy represents an important unmet need in neuropathic pain patients and there is an urgent need to develop a more effective pharmacotherapy. An increasing number of patients choose complementary medicine to relieve pain. Lavender essential oil (LEO) is approved by the European Medicines Agency as herbal medicine to relieve anxiety and stress. However, the capability of LEO to relieve other nervous system disorders such as neuropathic pain has never been established. Our work aimed to evaluate the antineuropathic properties of lavender on a spared nerve injury (SNI) model of neuropathic pain in mice. An acute oral administration of LEO (100 mg/kg) alleviated SNI-induced mechanical allodynia, evaluated in the von Frey test, with an intensity comparable to the reference drug pregabalin. Investigations into the mechanism of action showed that LEO markedly decreased the phosphorylation of ERK1, ERK2, and JNK1, and decreased the levels of iNOS in the spinal cord; involvement of the endocannabinoid system was also detected using in vitro inhibition of the FAAH and MALG enzymes as well as in vivo experiments with the CB1 antagonist. Conversely, no effect on P38 phosphorylation and NF-kB activation was detected. These antihyperalgesic effects appeared at the same dose able to induce antidepressant-like, anxiolytic-like, and anorexic effects. In addition, gavage with LEO did not significantly alter animals’ gross behavior, motor coordination, or locomotor activity, nor impaired memory functions. Oral administration of LEO could represent a therapeutic approach in the management of neuropathic pain states.

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“…In this sense, many clinical researchers have reported that treatment with aromatherapy or inhalation of lavender essential oil provides a reduction in the pain and inflammation of patients with different types of diseases, such as pediatric, postoperative pain, labor, and various chronic inflammatory diseases (Cardia et al, 2018;Nasiri et al, 2016;Olapour et al, 2013;Ou et al, 2012;Soltani et al, 2013;Yazdkhasti & Pirak, 2016). Besides, the topical application of lavender essential oil effectively reduces pain perception in patients with carpal tunnel syndrome, showing the possible effect of lavender oil on neuropathic pain (Eftekharsadat et al, 2018).…”

Section: Lavender Essential Oil Alleviates Pain and Inflammationmentioning

confidence: 99%

Pharmacological, medicinal and toxicological properties of lavender essential oil: A review

Cardia

Silva-Comar

Rocha

et al. 2021

RSD

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The natural products extracted from plants are part of traditional medicine and are also therapeutic possibilities for treating many diseases. Recently, its use in the development of new drugs has shown much visibility for its efficiency and few adverse effects. Essential oils extracted from medicinal plants are indicated to treat numerous diseases due to their antimicrobial, antiviral, antimutagenic, anticancer, antioxidant, anti-inflammatory, immunomodulatory, and antiprotozoal properties. Among essential oils, lavender essential oil stands out for having several important pharmacological properties. This review detailed the main studies on essential oils from different species of lavender and obtained a valuable collection on all their pharmacological, medicinal and toxicological potential. In this context, we evaluated lavender essential oil as a promising substance that can help treat several diseases. We provide some evidence and an overview of the potential therapeutic effect of lavender essential oil to guide new research.

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Effectiveness of Lavendula stoechas essential oil in treatment of mild to moderate carpal tunnel syndrome: A randomized controlled trial

Cited by 15 publications

References 36 publications

Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review

Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review

Lavender (Lavandula angustifolia Mill.) Essential Oil Alleviates Neuropathic Pain in Mice With Spared Nerve Injury

Pharmacological, medicinal and toxicological properties of lavender essential oil: A review

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