Effectiveness of Kaempferia Galanga Linn Rhizome's Extract Towards the Healing of Minor Recurrent Aphthous Stomatitis in RSGMP USU's Patients

Tambunan, Laurenzia Veronica; Lubis, Wilda Hafny

doi:10.7454/uiphm.v1i0.35

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…Ethyl- p -methoxycinnamate (EPMC) is one of the bioactive substances contained in KG extract in large quantities. EPMC isolated from KG extract has activity against Mycobacterium tuberculosis and Candida albicans [ 5 ]. Umar et al (2014) have confirmed the anti-inflammatory effects of EPMC on mouse and human macrophage cells.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Wahyuni,

Sufiawati,

Shafuria

et al. 2024

Pharmaceutics

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The rhizome of Kaempferia galanga (Zingiberaceae) is extensively used in traditional medicine by utilizing its various biological activities. It has been proven that ethyl-para-methoxycinnamate (EPMC) and other polyphenolic compounds are present in considerable amounts in the ethanolic extract of K. galanga rhizome (EKG). Our previous study confirmed that a dose of 0.5–1% of EKG demonstrated anti-inflammatory activity and a wound-healing effect in chemical-induced oral mucosal ulcers of Wistar rats. Currently, there are no reports on the formulation of oral gel containing EKG, thus revealing the potential of EKG to be developed as a herbal oral gel for mucosal ulcers. This study aims to formulate the best mucoadhesive oral care gel containing EKG in terms of physical stability. The presence of EPMC and the total phenols in the best EKG gel were also determined. The results revealed that Carbopol 934 is the best gelling agent for EKG gel preparations as proven by its stability during 14 days of storage. The statistical analysis resulted in a significant difference between the physical stability of the Carbopol 934-based EKG gel preparation compared to three commercial oral care gel products (p < 0.05). RP-HPLC chromatograms indicated that EPMC was identified in Carbopol 934-based gels containing 5% and 10% EKG at 6.056 and 6.146 min, respectively, with polyphenol levels of 1201.2557 mg/kg and 1849.1506 mg/kg, respectively. The hedonic test performed on 30 respondents to measure the degree of consumer acceptance and satisfaction confirmed that 5% EKG gel is the most sensorially accepted by the respondents. Data were analyzed using paired t-tests, one-way ANOVA, and a Kruskal–Wallis test. Taken together, the Carbopol 934-based gel containing 5% EKG could potentially be further developed as a topical anti-oral mucosal ulcer drug for clinical purposes.

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Section: Introductionmentioning

confidence: 99%

“…Prostaglandin biosynthesis increases in inflamed tissues and becomes a marker of acute inflammatory processes [ 7 , 8 ]. The inhibition of COX-2 by EPMC conduces an anti-inflammatory effect [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Wahyuni,

Sufiawati,

Shafuria

et al. 2024

Pharmaceutics

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“…30 Meanwhile, another clinical trial of topical K. galanga extract on 16 patients with recurrent aphthous stomatitis has showed good results in reducing the ulcer size and pain. 31 …”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats

Wahyuni¹,

Sufiawati²,

Nittayananta³

et al. 2022

JIR

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Introduction Kaempferia galanga L. ( K. galanga ; local name kencur , Zingiberaceae) is a plant commonly used as a kitchen spice, and empirically it is often used for medicinal purposes. This plant has been shown to have an anti-inflammatory role, but no research has been found on its effect on oral mucosal ulcer. This study aimed to investigate anti-inflammatory activity and wound healing effect of the ethanol extract of K. galanga L. rhizome (EEKG) on the chemical-induced oral mucosal ulcer in Wistar rats. Methods In this study, 35 rats were divided into 7 groups (normal, negative, triamcinolone acetonide, and 4 EEKG groups). Acetic acid 70% was used as the oral mucosal ulcer inducer. Parameters observed were macroscopic and microscopic histopathological examinations. Results The results revealed that dose of 0.5% of the EEKG was effective in increasing the percent recovery of ulcer area and inflammation sign scores. Meanwhile, doses of 0.5–2% of EEKG were effective in reducing the histopathological score. Interestingly, topical EEKG in our study was more effective compared with triamcinolone acetonide (the conventional therapy for oral mucosal ulceration). Discussion The EEKG has been confirmed its anti-inflammatory activity by accelerating the healing process on the chemical-induced oral mucosal ulcer in Wistar rats, based on the percent recovery of the ulcer area, the percent recovery of the inflammation sign score, and the histopathology score. Conclusion Taken together, K. galanga L. is very potential to be developed as a prospective phytopharmaceutical for the treatment of oral mucosal ulceration in human after clinical trials.

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“…The extract of kencur rhizomes (Kaempferia galanga L.) contains ethyl-p-methoxycinnamate (EPMS) that has an anti-inflammatory and analgesic (Riasari et al, 2016;Tambunan & Lubis, 2017;Umar et al, 2012) antidiabetic (Ernawati et al, 2017) and antioxidative effects (Riasari et al, 2016). EPMS is a lipophilic compound and low water solubility, resulting in low systemic bioavailability (Ekowati et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system

Pudyastuti¹,

Wijaya²

2022

Pharmaciana

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Kencur (Kaempferia galanga L.) rhizome ethanol extract contains a lipophilic compound of ethyl p-methoxycinnamate. Self-nanoemulsifying drug delivery system (SNEDDS) formulation can increase the solubility of the extract in water. The purpose of this study was to determine the effect of surfactant combination on the kencur rhizome extract in the SNEDDS system. The SNEDDS formulations were carried out by selecting the surfactant ratio of Tween 80:Span 80 and Tween 80:Chremophor RH 40, followed by selecting the ratio of surfactant mixtures to polyethylene glycol 400 as co-surfactant, and to virgin coconut oil as the oil phase. The clarity, transmittance, emulsification time, particle size, and polydispersity index were evaluated. The stability test was carried out in aquadest, artificial gastric fluid, and artificial intestinal fluid for 4 hours at 37°C. The results showed that the combination of Tween 80: Chremophor RH 40 produced better SNEDDS than Tween 80:Span 80. The combination of surfactant-cosurfactant of Tween 80:Chremophor RH 40:PEG 400 at ratio 3:1 and 1:1 could produce homogenous dispersed SNEDDS showing droplet size of 23,0 and 21,8 nm; transmittance of 95.63% and 93.83%, and SNEDDS preconcentrate emulsified less than 35 seconds. The single surfactant Tween 80:PEG 400 at the ratio 3:1 produce better dispersed SNEDDS than the combined surfactant with droplet size 16.3 nm, transmittance 97.85%, and SNEDDS preconcentrate emulsified less than 45 seconds. The SNEDDS system could produce a smaller droplet size than the extract in aquadest.

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Effectiveness of Kaempferia Galanga Linn Rhizome's Extract Towards the Healing of Minor Recurrent Aphthous Stomatitis in RSGMP USU's Patients

Cited by 4 publications

References 2 publications

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats

The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system

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