Effectiveness of individualized inhaler technique training on low adherence (LowAd) in ambulatory patients with COPD and asthma

Sánchez-Nieto, Juan Miguel; Bernabeu-Mora, Roberto; Fernández-Muñoz, Irene; Carrillo-Alcaraz, Andrés; Alcántara-Fructuoso, Juan; Fernández‐Álvarez, Javier; Vera-Olmos, Juan Carlos; Martínez-Ferre, María José; Olea, Mercedes Garci-Varela; Valenciano, Maria José Córcoles; Martínez, Domingo Antonio Manzanares

doi:10.1038/s41533-021-00262-8

Cited by 10 publications

(7 citation statements)

References 40 publications

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“… 45 A recent study, conducted in 2022, concluded that an individualized educational intervention can improve adherence to therapy among patients with asthma. 47 Furthermore, a systematic review and meta-analysis conducted in 2020 compared the impact of the pharmacist-led intervention on adherence to therapy in asthma/COPD patients between the pharmacist-led intervention group and control group, and concluded that adherence to therapy is significantly increased in the pharmacist-led intervention group vs control group. 48 …”

Section: Discussionmentioning

confidence: 99%

Can Pharmacists’ Counseling Improve the Use of Inhalers and Quality of Life? A Prospective “Pre” and “Post” Education Analysis in Mardan, Pakistan

Gul¹,

Rehman²,

Goh³

et al. 2023

JAA

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Introduction Asthma is one of the common major non-communicable respiratory diseases, and is associated with a lower health-related quality of life (QOL). Poor inhalation is a significant contributing factor to poor control of asthma. Community pharmacist has a vital role to play in assisting patients and ultimately improving their asthma conditions through the use of inhalers. Aim This study aimed to assess the effectiveness of “pre” and “post” educational intervention by a community pharmacist within a community pharmacy on asthma patients’ QOL, inhaler technique, and adherence to therapy during the endemic phase of COVID-19. Methods A “pre” and “post” interventional study was performed at a community pharmacy in the city of Mardan, Pakistan, in 2022 during the COVID-19 pandemic. Patients were divided into two groups, ie control and pharmacist-led education groups. After assigning patients to both groups, the baseline data were collected and followed for one month to compare the reduction in errors in the use of inhalers, QOL, and adherence to therapy. A paired sample t -test was performed, keeping a p-value <0.05 as statistical significance. Results A total of 60 patients were recruited, majority (58.3%) were females, and 28.3% were from the age group of 46–55 years old. A statistically significant difference was observed in the pre- and post-education QOL score among patients in the pharmacist-led education group, from a mean ± SD at pre-education of 40.23±10.03 to a mean±SD at post-education of 48.10±5.68. Similarly, a statistically significant difference was observed for the correct use of inhalers, ie MDIs and DPIs. Similarly, a statistically significant difference was observed in the adherence status between pre-education and post-education by pharmacists. Conclusion The findings of the study revealed a positive impact of community pharmacist-led education on QOL, inhaler technique, and adherence to therapy among patients with asthma.

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Section: Discussionmentioning

confidence: 99%

Can Pharmacists’ Counseling Improve the Use of Inhalers and Quality of Life? A Prospective “Pre” and “Post” Education Analysis in Mardan, Pakistan

Gul¹,

Rehman²,

Goh³

et al. 2023

JAA

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“…also indicated that the asthma group was significantly more satisfied with inhaled therapy using an inhaler [ 23 ]. In the Sánchez-Nieto study, there were no significant differences in adherence between asthma and COPD patients at the start of the study, and the only predictor of low adherence was the gender of the participant being female [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment Adherence in Patients with Obstructive Pulmonary Diseases

Homętowska

Świątoniowska-Lonc²,

Klekowski

et al. 2022

IJERPH

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COPD is the third most common cause of death globally. Adherence rates in patients with obstructive pulmonary diseases usually range between 10% and 40%. The aim of the study was to evaluate the level of treatment adherence to inhaled therapy in patients with obstructive pulmonary diseases. A total of 325 patients, of mean age 63.04 ± 11.29, with COPD or asthma, were included into the study between 2020 and 2021. The following questionnaires were used: Beliefs about Medicines Questionnaire, Test of Adherence to Inhalers and Adherence to Refills and Medications Scale. The respondents tended to be convinced of the necessity of their medication (3.87 points per question). The patients reported moderate levels of overall adherence (21.15 ± 6.23). A total of 74% of patients demonstrated sporadic non-compliance. We conclude that patients with obstructive pulmonary diseases are moderately adherent to their medication. Beliefs about medicines have a significant impact on adherence to medications. Being unemployed, being a non-smoker and belief in the necessity of medication are independent determinants of better medication adherence. The number of hospital admissions due to exacerbations of the disease over the last year and belief that medicines are harmful are independent determinants of poorer medication adherence.

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“…Furthermore, in the severe COPD individuals, loss of the Normal functioning of the ACE-2 results in increased inflammatory responses further leads to vasoconstriction and vascular damage. Once after the entry, the fusion between SARS-CoV-2 and host cells takes place with the help of spike-like proteins present on the surface of the virus, which uses the various proteolytic enzymes such as furin, transmembrane serine protease 2 (TMPRSS2) and cathepsin [ 24 ]. The pathophysiological conditions of the suspects from the COPD shows more sensitive to SARS-CoV-2 infections due to variations in production of ACE-2, regulation of this enzyme which is used as a key factor in reducing the SARS-CoV-2 infections in COPD individuals [ 10 ].…”

Section: End Stage -Consolidation With Infectionsmentioning

confidence: 99%

“…P. aeruginosa is commonly found in the respiratory tract due to its preference for a wet environment. Epidemiological features of P. aeruginosa in association with COPD have been studied, revealing a low prevalence in mild cases but an increased risk during acute exacerbations [ 24 ]. Studies have reported that P. aeruginosa clinical isolates are found more frequently in patients with severe airway obstructions and chronic bronchitis [ 10 ].…”

Section: Synergistic Corelations Of Covid-19 and P Aerugino...mentioning

confidence: 99%

Synergistic effects of COVID-19 and Pseudomonas aeruginosa in chronic obstructive pulmonary disease: a polymicrobial perspective

Bajire

Shastry

2023

Mol Cell Biochem

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This article discusses the connection between the novel coronavirus disease 2019 (COVID-19) caused by the coronavirus-2 (SARS-CoV-2) and chronic obstructive pulmonary disease (COPD). COPD is a multifaceted respiratory illness that is typically observed in individuals with chronic exposure to chemical irritants or severe lung damage caused by various pathogens, including SARS-CoV-2 and Pseudomonas aeruginosa . The pathogenesis of COPD is complex, involving a variety of genotypes and phenotypic characteristics that result in severe co-infections and a poor prognosis if not properly managed. We focus on the role of SARS-CoV-2 infection in severe COPD exacerbations in connection to P. aeruginosa infection, covering pathogenesis, diagnosis, and therapy. This review also includes a thorough structural overview of COPD and recent developments in understanding its complicated and chronic nature. While COVID-19 is clearly linked to emphysema and chronic bronchitis at different stages of the disease, our understanding of the precise interaction between microbial infections during COPD, particularly with SARS-CoV-2 in the lungs, remains inadequate. Therefore, it is crucial to understand the host–pathogen relationship from the clinician’s perspective in order to effectively manage COPD. This article aims to provide a comprehensive overview of the subject matter to assist clinicians in their efforts to improve the treatment and management of COPD, especially in light of the COVID-19 pandemic.

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Effectiveness of individualized inhaler technique training on low adherence (LowAd) in ambulatory patients with COPD and asthma

Cited by 10 publications

References 40 publications

Can Pharmacists’ Counseling Improve the Use of Inhalers and Quality of Life? A Prospective “Pre” and “Post” Education Analysis in Mardan, Pakistan

Can Pharmacists’ Counseling Improve the Use of Inhalers and Quality of Life? A Prospective “Pre” and “Post” Education Analysis in Mardan, Pakistan

Treatment Adherence in Patients with Obstructive Pulmonary Diseases

Synergistic effects of COVID-19 and Pseudomonas aeruginosa in chronic obstructive pulmonary disease: a polymicrobial perspective

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