Effectiveness of Household Disinfection Techniques to Remove SARS-CoV-2 from Cloth Masks

Mares-Guia, Maria Angélica; Paiva, Anne Aline Pereira de; Mello, Vinicius M.; Eller, Cristiane M.; Lemos, Andreza Sálvio; Nascimento, Felipe Franco; Silva, Emanuelle S. R. F.; Guerra-Campos, Vinícius; Mendes, Ygara da Silva; Lemos, Elba Regina Sampaio de; Sousa, Ivanildo P.; Horta, Marco Aurélio Pereira

doi:10.3390/pathogens11080916

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…The study showed that all biocidal treatments successfully disinfected the tissue tested. This work was published in Pathogens in 2022, under the [90].…”

Section: Discussionmentioning

confidence: 99%

Molecular Mimicry between SARS-CoV-2 Proteins and Human Self-Antigens Related with Autoimmune Central Nervous System (CNS) Disorders

Gutman,

Fernandes,

Raposo-Vedovi

et al. 2023

Microorganisms

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SARS-CoV-2 can trigger autoimmune central nervous system (CNS) diseases in genetically susceptible individuals, a mechanism poorly understood. Molecular mimicry (MM) has been identified in other viral diseases as potential triggers of autoimmune CNS events. This study investigated if MM is the process through which SARS-CoV-2 induces the breakdown of immune tolerance. The frequency of autoimmune CNS disorders was evaluated in a prospective cohort with patients admitted to the COVID-19 Intense Care Unity (ICU) in Rio de Janeiro. Then, an in silico analysis was performed to identify the conserved regions that share a high identity between SARS-CoV-2 antigens and human proteins. The sequences with significant identity and antigenic properties were then assessed for their binding capacity to HLA subtypes. Of the 112 patients included, 3 were classified as having an autoimmune disorder. A total of eleven combinations had significant linear and three-dimensional overlap. NMDAR1, MOG, and MPO were the self-antigens with more significant combinations, followed by GAD65. All sequences presented at least one epitope with strong or intermediate binding capacity to the HLA subtypes selected. This study underscores the possibility that CNS autoimmune attacks observed in COVID-19 patients, including those in our population, could be driven by MM in genetically predisposed individuals.

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“…The study showed that all biocidal treatments successfully disinfected the tissue tested. This work was published in Pathogens in 2022, under the [90].…”

Section: Discussionmentioning

confidence: 99%

Molecular Mimicry between SARS-CoV-2 Proteins and Human Self-Antigens Related with Autoimmune Central Nervous System (CNS) Disorders

Gutman,

Fernandes,

Raposo-Vedovi

et al. 2023

Microorganisms

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“…Samples presenting a CT > 35 were considered negative. This standard curve was obtained by purification, quantification, and serial-dilution of SARS-CoV-2 from cell culture [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19

Salvio,

Fernandes,

Ferreira

et al. 2023

Mol Neurobiol

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Few studies showed that neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tubulin-associated unit (TAU), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) may be related to neurological manifestations and severity during and after SARS-CoV-2 infection. The objective of this work was to investigate the relationship among nervous system biomarkers (NfL, TAU, GFAP, and UCH-L1), biochemical parameters, and viral loads with heterogeneous outcomes in a cohort of severe COVID-19 patients admitted in Intensive Care Unit (ICU) of a university hospital. For that, 108 subjects were recruited within the first 5 days at ICU. In parallel, 16 mild COVID-19 patients were enrolled. Severe COVID-19 group was divided between “deceased” and “survivor.” All subjects were positive for SARS-CoV-2 detection. NfL, total TAU, GFAP, and UCH-L1 quantification in plasma was performed using SIMOA SR-X platform. Of 108 severe patients, 36 (33.33%) presented neurological manifestation and 41 (37.96%) died. All four biomarkers — GFAP, NfL, TAU, and UCH-L1 — were significantly higher among deceased patients in comparison to survivors (p < 0.05). Analyzing biochemical biomarkers, higher Peak Serum Ferritin, D-Dimer Peak, Gamma-glutamyltransferase, and C-Reactive Protein levels were related to death (p < 0.0001). In multivariate analysis, GFAP, NfL, TAU, UCH-L1, and Peak Serum Ferritin levels were correlated to death. Regarding SARS-CoV-2 viral load, no statistical difference was observed for any group. Thus, Ferritin, NFL, GFAP, TAU, and UCH-L1 are early biomarkers of severity and lethality of SARS-COV-2 infection and may be important tools for therapeutic decision-making in the acute phase of disease.

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“…This standard curve was obtained by puri cation, quanti cation and serialdilution of SARS-CoV-2 from cell culture. [19]…”

Section: Sars-cov-2 Detection and Quanti Cationmentioning

confidence: 99%

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus disease 2019 (COVID- 19) and can be responsible for a wide range of different outcomes, varying from asymptomatic infection, mild disease and even severe acute respiratory syndrome (SARS) and death. [1,2] Although the end of the Public Health Emergency of International Concern for COVID-19 was decreed by the World Health Organization (WHO), on May 5th, 2023, [3] it brought us all relevant questioning, mainly regarding the patients' management and monitoring.…”

Section: Introductionmentioning

confidence: 99%

High levels of NfL, GFAP, TAU and UCH-L1 as potential predictor biomarkers of severity and lethality in acute COVID-19

Salvio,

Fernandes,

Ferreira

et al. 2023

Preprint

Self Cite

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Few studies showed that neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tubulin associated unit (TAU), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) may be related to neurological manifestations and severity during and after SARS-CoV-2 infection. The objective of this work was to investigate the relationship among nervous system biomarkers (NfL, TAU, GFAP and UCH-L1) and viral loads with heterogeneous outcomes in a cohort of severe COVID-19 patients admitted in Intensive Care Unit (ICU) of a university hospital. For that, 108 subjects were recruited within the first five days at ICU. In parallel, 18 mild COVID-19 patients were enrolled. Severe COVID-19 group was divided between “deceased” and “survivor”. All subjects were positive for SARS-CoV-2 detection. NfL, total TAU, GFAP and UCH-L1 quantification in plasma was performed using SIMOA SR-X platform. Of 108 severe patients (mean age 62.92 years old; male: 49.08%; female: 50.92%). Among them, thirty-six (33.33%) presented neurological manifestation and forty-one (37.96%) died. All four biomarkers – GFAP, NfL, TAU and UCH-L1 – were significantly higher among deceased patients in comparison to survivors (p < 0.05). Analyzing biochemical biomarkers, higher Ferritin Peak levels was related to death (p < 0.0001). In multivariate analysis, GFAP, NfL, TAU, UCH-L1 and Ferritin Peak were correlated to death. Regarding SARS-CoV-2 viral load, no statistical difference was observed for any group. Thus, Ferritin, NFL, GFAP, TAU and UCH-L1 are early biomarkers of severity and lethality of SARS-COV-2 infection and may be important tools for therapeutic decision-making in the acute phase of disease.

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Effectiveness of Household Disinfection Techniques to Remove SARS-CoV-2 from Cloth Masks

Cited by 4 publications

References 43 publications

Molecular Mimicry between SARS-CoV-2 Proteins and Human Self-Antigens Related with Autoimmune Central Nervous System (CNS) Disorders

Molecular Mimicry between SARS-CoV-2 Proteins and Human Self-Antigens Related with Autoimmune Central Nervous System (CNS) Disorders

High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19

High levels of NfL, GFAP, TAU and UCH-L1 as potential predictor biomarkers of severity and lethality in acute COVID-19

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