Effectiveness of holistic mobile health interventions on diet, and physical, and mental health outcomes: a systematic review and meta-analysis

Zheng, Shenglin; Edney, Sarah Martine; Goh, Chin Hao; Tai, Bee Choo; Mair, Jacqueline Louise; Castro, Oscar; Salamanca-Sanabria, Alicia; Kowatsch, Tobias; van Dam, Rob M.; Müller-Riemenschneider, Falk

doi:10.1016/j.eclinm.2023.102309

Cited by 4 publications

(1 citation statement)

References 89 publications

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“…Importantly, sedentary behaviour, which demonstrated significant association with incident dementia ( 60 ), may have deleterious independent and/or exercise-counteracting effects on brain physiopathology. All of these factors may act synergistically and potentiate the single effects of each individually, emphasizing the need for holistic approach interventions to prevent dementia ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Does Physical Exercise Modify the Pathophysiology of Alzheimer’s Disease in Older Persons?

Raffin

2024

J Aging Res & Lifestyle

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Physical exercise is well known for its benefits on brain health. However, the mechanisms through which these benefits occur remain discussed, especially in the context of cognitive conditions such as Alzheimer’s disease. The present short review summarizes the findings of interventional studies that examined the effects of exercise training on the specific and non-specific biomarkers of Alzheimer’s disease. Controlled exercise intervention studies published in the English language were selected if they assessed the effects of a physical exercise intervention of at least 2 weeks in middle-aged or older adults on one of the following biomarkers measured either in the brain, the cerebrospinal fluid or the blood: beta-amyloid, tau, neurofilament light chain, and glial fibrillary acidic protein. Overall, there was no strong evidence of significant effects of exercise interventions on any of the selected biomarkers. However, in specific populations, such as women with obesity, pre-diabetes, or depression, favorable changes in blood beta-amyloid concentrations were reported. Further benefits on cerebrospinal fluid beta-amyloid were also demonstrated in APOE-ε4 allele carriers with Alzheimer’s disease. In conclusion, the current evidence suggests that physical exercise does not modulate the pathophysiology of Alzheimer’s disease in the overall population of middle-aged and older adults. Nonetheless, some specific populations, such as women with metabolic disorders and Alzheimer’s disease patients with APOE-ε4 genotype, seem to be favorably affected. Further studies, including long follow-ups, large sample sizes, and concomitantly assessing the effects of other factors such as sedentary behavior and diet, are required to bring further evidence to the field.

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Section: Discussionmentioning

confidence: 99%

Does Physical Exercise Modify the Pathophysiology of Alzheimer’s Disease in Older Persons?

Raffin

2024

J Aging Res & Lifestyle

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Remote mobile health monitoring frameworks and mobile applications: Taxonomy, open challenges, motivation, and recommendations

Aziz Butt,

Naseer,

Ali

et al. 2024

Engineering Applications of Artificial Intelligence

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A holistic lifestyle mobile health intervention for the prevention of type 2 diabetes and common mental disorders in Asian women with a history of gestational diabetes: a randomised control trial with 3-year follow-up protocol

Salamanca-Sanabria,

Liew,

Mair

et al. 2024

Trials

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Background Women with a history of gestational diabetes mellitus (GDM) are 12-fold more likely to develop type 2 diabetes (T2D) 4–6 years after delivery than women without GDM. Similarly, GDM is associated with the development of common mental disorders (CMDs) (e.g. anxiety and depression). Evidence shows that holistic lifestyle interventions focusing on physical activity (PA), dietary intake, sleep, and mental well-being strategies can prevent T2D and CMDs. This study aims to assess the effectiveness of a holistic lifestyle mobile health intervention (mHealth) with post-GDM women in preventing T2D and CMDs in a community setting in Singapore. Methods The study consists of a 1-year randomised controlled trial (RCT) with a 3-year follow-up period. Post-GDM women with no current diabetes diagnosis and not planning to become pregnant will be eligible for the study. In addition, participants will complete mental well-being questionnaires (e.g. depression, anxiety, sleep) and their child’s socio-emotional and cognitive development. The participants will be randomised to either Group 1 (Intervention) or Group 2 (comparison). The intervention group will receive the “LVL UP App”, a smartphone-based, conversational agent-delivered holistic lifestyle intervention focused on three pillars: Move More (PA), Eat Well (Diet), and Stress Less (mental wellbeing). The intervention consists of health literacy and psychoeducational coaching sessions, daily “Life Hacks” (healthy activity suggestions), slow-paced breathing exercises, a step tracker (including brisk steps), a low-burden food diary, and a journaling tool. Women from both groups will be provided with an Oura ring for tracking physical activity, sleep, and heart rate variability (a proxy for stress), and the “HAPPY App”, a mHealth app which provides health promotion information about PA, diet, sleep, and mental wellbeing, as well as display body mass index, blood pressure, and results from the oral glucose tolerance tests. Short-term aggregate effects will be assessed at 26/27 weeks (midpoint) and a 1-year visit, followed by a 2, 3, and 4-year follow-up period. Discussion High rates of progression of T2D and CMDs in women with post-GDM suggest an urgent need to promote a healthy lifestyle, including diet, PA, sleep, and mental well-being. Preventive interventions through a holistic, healthy lifestyle may be the solution, considering the inextricable relationship between physical and psychological health. We expect that holistic lifestyle mHealth may effectively support behavioural changes among women with a history of GDM to prevent T2D and CMDs. Trial status The protocol study was approved by the National Healthcare Group in Singapore, Domain Specific Review Board (DSRB) [2023/00178]; June 2023. Recruitment began on October 18, 2023. Trial registration ClinicalTrials.gov NCT05949957. The first submission date is June 08, 2023.

show abstract

Effectiveness of holistic mobile health interventions on diet, and physical, and mental health outcomes: a systematic review and meta-analysis

Cited by 4 publications

References 89 publications

Does Physical Exercise Modify the Pathophysiology of Alzheimer’s Disease in Older Persons?

Does Physical Exercise Modify the Pathophysiology of Alzheimer’s Disease in Older Persons?

Remote mobile health monitoring frameworks and mobile applications: Taxonomy, open challenges, motivation, and recommendations

A holistic lifestyle mobile health intervention for the prevention of type 2 diabetes and common mental disorders in Asian women with a history of gestational diabetes: a randomised control trial with 3-year follow-up protocol

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