Effectiveness of Helminths in Two Different Mice Strains in a Murine Model of Anaphylaxis

Martín, G.; Rotta, A. La; Rodríguez, Ana; Baeza, M.L.

doi:10.1016/j.jaci.2010.12.979

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Microbiome Modification: Probiotics and Helminths1

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2022

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“…Helminths have been considered as potential intestinal immunomodulators [107]. Studies of peanut allergy in mouse models have shown that helminths are safe and able to suppress the production of peanutspecific IgE [108].…”

Section: Microbiome Modification: Probiotics and Helminthsmentioning

confidence: 99%

Celiac Disease: Disease Models in Understanding Pathogenesis and Search for Therapy

Chaykin

Odintsova²,

Nedorubov³

2022

Open Access Maced J Med Sci

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Celiac disease is a complex polygenic systemic disorder caused by dietary gluten exposure that selectively occurs in genetically susceptible people. The potential celiac disease is defined by the presence of celiac disease-specific antibodies and compatible human leukocyte antigen but without histological abnormalities in duodenal biopsies. At present, the only treatment is lifelong adherence to a gluten-free diet. Despite its effectiveness, the diet is difficult to maintain due to its cost, availability of gluten-free foods, and hidden gluten. The need to develop non-dietary treatment methods is widely recognized, but this is prevented by the absence of a pathophysiologically relevant preclinical model. Nonetheless, in vitro and in vivo models have made it possible to investigate the mechanisms of the disease and develop new treatment approaches: The use of foods with neutralized gluten, microbiota correction, cocktails of specific endoproteinase, polymer gluten binders, specific inhibitors of transglutaminases and inflammatory cytokines, and a vaccine based on allergen-specific therapy.

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Section: Microbiome Modification: Probiotics and Helminthsmentioning

confidence: 99%