Effectiveness of heart rate control on hemodynamics in critically ill patients with atrial tachyarrhythmias managed by amiodarone

Background: Ibrutinib has revolutionized treatment for several B-cell malignancies. However, a recent clinical trial where ibrutinib was used in front-line setting showed increased mortality during treatment compared to conventional chemotherapy. Cardiovascular toxicities were suspected as the culprit but not directed assessed in the study. Objective: We aimed to identify and characterize cardiovascular adverse drug reactions (CV-ADR) associated with ibrutinib. Methods: We utilized VigiBase (International pharmacovigilance database) and performed a disproportionality analysis using reporting odds-ratios (ROR) and information component (IC) to determine whether CV-ADR and CV-ADR deaths were associated with ibrutinib. IC compares observed and expected values to find associations between drugs and ADR using disproportionate Bayesianreporting; IC025 (lower end of the IC 95% credibility interval)> 0 is significant. Results: We identified 303 ibrutinib-associated cardiovascular deaths. Ibrutinib was associated with

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Cardiovascular Toxicities Associated With Ibrutinib

Salem

Manouchehri

Bretagne

et al. 2019

Journal of the American College of Cardiology

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195

173

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Propafenone for supraventricular arrhythmias in septic shock—Comparison to amiodarone and metoprolol

Khoury

Azzam

2018

Journal of Critical Care

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2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)

Brugada

Katritsis

Arbelo³

et al. 2019

European Heart Journal

777

612

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Effectiveness of heart rate control on hemodynamics in critically ill patients with atrial tachyarrhythmias managed by amiodarone

Cited by 3 publications

References 35 publications

Cardiovascular Toxicities Associated With Ibrutinib

Cardiovascular Toxicities Associated With Ibrutinib

Propafenone for supraventricular arrhythmias in septic shock—Comparison to amiodarone and metoprolol

2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)

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